New hope for tough prostate cancer: combo therapy aims to delay disease worsening
NCT ID NCT06551324
First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 32 times
Summary
This study tests whether adding an experimental drug (PF-06821497) to standard enzalutamide works better than standard treatments alone for men with metastatic castration-resistant prostate cancer that has progressed after abiraterone. About 600 participants will be randomly assigned to receive either the combination or a standard treatment (enzalutamide or chemotherapy). The main goal is to see how long the cancer stays under control.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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4 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ
Wroclaw, Lower Silesian Voivodeship, 50-981, Poland
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AUC Urologists, LLC
Myrtle Beach, South Carolina, 29572, United States
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Adana City Hospital
Adana, 01370, Turkey (Türkiye)
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AdventHealth Hematology and Oncology
Orlando, Florida, 32804, United States
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AdventHealth Orlando Infusion Center
Orlando, Florida, 32804, United States
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Alexandra General Hospital of Athens
Athens, Attikí, 115 28, Greece
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Althaia, Xarxa Assistencial Universitària de Manresa
Manresa, 8423, Spain
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Ankara University Health Practice and Research Hospitals
Ankara, 06620, Turkey (Türkiye)
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Arthur J.E. Child Comprehensive Cancer Centre
Calgary, Alberta, T2N 5G2, Canada
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Asan Medical Center
Seoul, Seoul-teukbyeolsi [seoul], 05505, South Korea
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Asociación de Beneficencia Hospital Sirio Libanés
Buenos Aires, C1419AHN, Argentina
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Athens Medical Center
Athens, Attikí, 151 25, Greece
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AtlantiCare
Egg Harbor, New Jersey, 08234, United States
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AtlantiCare Health Park - Cape May Court House
Cape May Court House, New Jersey, 08210, United States
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BC Cancer Vancouver
Vancouver, British Columbia, V5Z 4E6, Canada
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BEKY - MED, s.r.o.
Prešov, 080 01, Slovakia
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Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, 100050, China
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CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia
Santo André, São Paulo, 09060-650, Brazil
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CHRU de Brest
Brest, Finistère, 29200, France
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Canisius-Wilhelmina Ziekenhuis
Nijmegen, Gelderland, 6532 SZ, Netherlands
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Carolina Urologic Research Center, LLC
Myrtle Beach, South Carolina, 29572, United States
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Centre Antoine Lacassagne
Nice, Alpes-maritimes, 06189, France
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Centre Antoine-Lacassagne
Nice, Alpes-maritimes, 06189, France
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Centre Hospitalier Lyon Sud
Pierre-Bénite, Rhône, 69310, France
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Centre Hospitalier Privé Saint-Grégoire
Saint-Grégoire, Ille-et-vilaine, 35760, France
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Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire
Nîmes, GARD, 30029, France
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Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, H2X 3E4, Canada
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Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne
Clermont-Ferrand, 63011, France
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Centre Leon Berard
Lyon Cedex08, Auvergne-Rhône-Alpes, 69373, France
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Centre Oscar Lambret
Lille, Hauts-de-France, 59020, France
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Centro Medico Privado CEMAIC
Capital, Córdoba Province, X5008HHW, Argentina
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Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)
Buenos Aires, C1431FWO, Argentina
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Centro de Urología (CDU)
CABA, Buenos Aires, C1120AAT, Argentina
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Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o.
Krakow, Lesser Poland Voivodeship, 30-348, Poland
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Chang Gung Medical Foundation-Linkou Branch
Taoyuan, 333, Taiwan
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Chiba cancer center
Chiba, Chiba, 260-8717, Japan
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Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality, 400030, China
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Chonnam National University Hwasun Hospital
Hwasun, Jeonranamdo, 58128, South Korea
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Circuit Clinical
Middletown, New York, 10941, United States
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Circuit Clinical /Crystal Run Healthcare LLP
Middletown, New York, 10941, United States
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Colorado Clinical Research
Lakewood, Colorado, 80228, United States
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Crio - Centro Regional Integrado de Oncologia
Fortaleza, Ceará, 60336232, Brazil
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Crystal Run Healthcare
Monroe, New York, 10950, United States
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Duly Health and Care
Lisle, Illinois, 60532, United States
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Duly Health and Care
Westmont, Illinois, 60559, United States
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Ewha Womans University Mokdong Hospital
Seoul, Seoul-teukbyeolsi [seoul], 07985, South Korea
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Fakultna nemocnica Trnava
Trnava, 917 02, Slovakia
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Fakultni Thomayerova nemocnice
Prague, Praha 4, 14059, Czechia
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Fakultni nemocnice Kralovske Vinohrady
Prague, Praha 10, 10034, Czechia
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Fakultni nemocnice Olomouc
Olomouc, Olomouc Region, 779 00, Czechia
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Florida Cancer Specialists
Bonita Springs, Florida, 34135, United States
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Florida Cancer Specialists
Bradenton, Florida, 34211, United States
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Florida Cancer Specialists
Cape Coral, Florida, 33909, United States
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Florida Cancer Specialists
Fort Myers, Florida, 33905, United States
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Florida Cancer Specialists
Fort Myers, Florida, 33908, United States
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Florida Cancer Specialists
N. Venice, Florida, 34275, United States
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Florida Cancer Specialists
Naples, Florida, 34102, United States
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Florida Cancer Specialists
Port Charlotte, Florida, 33980, United States
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Florida Cancer Specialists
Sarasota, Florida, 34236, United States
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Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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Frisius Medisch Centrum
Leeuwarden, Provincie Friesland, 8934 AD, Netherlands
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Fujian Cancer Hospital
Fuzhou, Fujian, 350014, China
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Fujian Medical University Union Hospital
Fuzhou, Fujian, 350001, China
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Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, São Paulo, 15090000, Brazil
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Gazi University Health Research and Application Center Gazi Hospital
Ankara, 06560, Turkey (Türkiye)
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Grand Strand Medical Center
Myrtle Beach, South Carolina, 29572, United States
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Guangzhou First People's Hospital
Guangzhou, Guangdong, 510180, China
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Gulhane Egitim Arastirma Hastanesi
Ankara, 06010, Turkey (Türkiye)
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Gustave Roussy
Villejuif, Val-de-marne, 94800, France
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Harborview Medical Center
Seattle, Washington, 98104, United States
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Hokkaido University Hospital
Sapporo, Hokkaido, 060-8648, Japan
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Hopitaux Universitaire de Strasbourg - Hopital Hautepierre
Strasbourg, Bas-rhin, 67091, France
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Hospital Alemao Oswaldo Cruz
São Paulo, São Paulo, 01327-001, Brazil
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Hospital Clínic de Barcelona
Barcelona, Catalunya [cataluña], 08036, Spain
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Hospital General Universitario Gregorio Marañon
Madrid, 28007, Spain
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Hospital São Carlos
Fortaleza, Ceará, 60135-237, Brazil
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Hospital São Lucas da PUCRS
Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
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Hospital Universitari i Politecnic La Fe
Valencia, 46026, Spain
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Hospital Universitario 12 de Octubre
Madrid, Madrid, Comunidad de, 28041, Spain
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Hospital Universitario Fundación Jiménez Díaz
Madrid, 28040, Spain
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Hospital Universitario HM Sanchinarro
Madrid, 28050, Spain
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Hospital Universitario Ramón y Cajal
Madrid, Madrid, Comunidad de, 28034, Spain
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Hospital de Base de São José do Rio Preto
São José do Rio Preto, São Paulo, 15090-000, Brazil
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Hospital de la Santa Creu i Sant Pau
Barcelona, Catalunya [cataluña], 08041, Spain
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Huai'an First People's Hospital
Huai'an, Jiangsu, 223300, China
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Hunan Cancer Hospital
Changsha, Hunan, 410013, China
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Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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Hôpital Foch
Suresnes, Hauts-de-seine, 92151, France
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I.E.U. Medical Point Hastanesi
Cordaleo, İzmir, 35575, Turkey (Türkiye)
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IBCC - Núcleo de Pesquisa e Ensino
São Paulo, 04014-002, Brazil
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IMAXE
Buenos Aires, C1120, Argentina
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IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
Meldola, Emilia-Romagna, 47014, Italy
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Icon Cancer Centre Wesley
Auchenflower, Queensland, 4066, Australia
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Imagenes Mdq
Mar del Plata, Buenos Aires, 7600, Argentina
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Institut Català d'Oncologia - L'Hospitalet
L'Hospitalet de Llobregat, Barcelona, 08908, Spain
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Institut Jean Godinot
Reims, Marne, 51726, France
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Instituto Alexander Fleming
Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina
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Instituto de Investigaciones Clínicas Mar del Plata
Mar del Plata, Buenos Aires, B7600FZO, Argentina
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Instituto do Cancer Arnaldo Vieira de Carvalho
São Paulo, 01221-020, Brazil
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Ironwood Cancer & Research Centers
Chandler, Arizona, 85224, United States
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Ironwood Cancer & Research Centers
Gilbert, Arizona, 85297, United States
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Ironwood Cancer & Research Centers
Glendale, Arizona, 85306, United States
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Ironwood Cancer & Research Centers
Mesa, Arizona, 85202, United States
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Ironwood Cancer & Research Centers
Mesa, Arizona, 85206, United States
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Ironwood Cancer & Research Centers
Phoenix, Arizona, 85028, United States
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Ironwood Cancer & Research Centers
Scottsdale, Arizona, 85260, United States
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Istanbul Universitesi Cerrahpasa
Istanbul, İ̇stanbul, 34668, Turkey (Türkiye)
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Istituto Nazionale Tumori Regina Elena
Rome, Lazio, 00144, Italy
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James J. Peters VA Medical Center
The Bronx, New York, 10468, United States
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Kanazawa University Hospital
Kanazawa, Ishikawa-ken, 920-8641, Japan
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Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
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Keio university hospital
Shinjuku-ku, Tokyo, 1608582, Japan
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Kobe University Hospital
Kobe, Hyōgo, 650-0017, Japan
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Koç Üniversitesi Hastanesi
Istanbul, İ̇stanbul, 34010, Turkey (Türkiye)
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Kyungpook National University Chilgok Hospital
Daegu, Taegu-kwangyǒkshi, 41404, South Korea
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Lanzhou university second hospital
Lanzhou, Gansu, 730030, China
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Los Angeles Cancer Network
Anaheim, California, 92801, United States
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Los Angeles Cancer Network
Fountain Valley, California, 92708, United States
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Los Angeles Cancer Network
Glendale, California, 91204, United States
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Los Angeles Cancer Network
Glendale, California, 91206, United States
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Los Angeles Cancer Network
Los Angeles, California, 90017, United States
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Los Angeles Cancer Network
Los Angeles, California, 90067, United States
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MICS Centrum Medyczne Torun
Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
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MILAB, s.r.o., Urologicka ambulancia
Prešov, 08 001, Slovakia
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Marmara Universitesi Pendik Egitim Arastirma Hastanesi
Istanbul, İ̇stanbul, 34899, Turkey (Türkiye)
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Meander Medisch Centrum
Amersfoort, Utrecht, 3813 TZ, Netherlands
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Memorial Ankara Hastanesi
Ankara, 06520, Turkey (Türkiye)
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Metropolitan General Hospital
Athens, Attikí, 155 62, Greece
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Mid and South Essex NHS Foundation Trust
Westcliff-on-Sea, Essex, SS0 0RY, United Kingdom
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Monash Health
Clayton, Victoria, 3168, Australia
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Multiscan
Pardubice, Pardubice Region, 53203, Czechia
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Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
Nanjing, Jiangsu, 210000, China
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Nantong Tumor Hospital
Nantong, Jiangsu, 226361, China
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National Cancer Center
Goyang-si, Kyǒnggi-do, 10408, South Korea
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National Cancer Center Hospital East
Kashiwa, Chiba, 277-8577, Japan
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National Cheng Kung University Hospital
Tainan, 704, Taiwan
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National Hospital Organization Hokkaido Cancer Center
Sapporo, Hokkaido, 003-0804, Japan
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National Hospital Organization Kumamoto Medical Center
Kumamoto, 860-0008, Japan
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National Hospital Organization Kyushu Cancer Center
Fukuoka, 811-1395, Japan
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National Hospital Organization Shikoku Cancer Center
Matsuyama, Ehime, 791-0280, Japan
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National Taiwan University Hospital
Taipei, 100225, Taiwan
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New England Cancer Specialists
Topsham, Maine, 04086, United States
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New England Cancer Specialists
Westbrook, Maine, 04092, United States
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NextStage Clinical Research-Chicago-(04)
Lisle, Illinois, 60532, United States
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Nukleární Medicína
Hradec Králové, 500 05, Czechia
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Oncopole Claudius Regaud
Toulouse, Haute-garonne, 31059, France
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Országos Onkológiai Intézet
Budapest, Pest County, 1122, Hungary
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Osaka International Cancer Institute
Osaka, 541-8567, Japan
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Ospedale San Raffaele
Milan, 20132, Italy
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Parkway Surgery Center
Myrtle Beach, South Carolina, 29572, United States
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Peking University Third Hospital
Beijing, Beijing Municipality, 100191, China
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Peter MacCallum Cancer Centre
Melbourne, Victoria, 3000, Australia
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Petz Aladar Egyetemi Oktato Korhaz
Győr, Győr-Moson-Sopron, 9024, Hungary
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Radiodiagnostika Pardubice
Pardubice, 53003, Czechia
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Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego
Grudziądz, Kuyavian-Pomeranian Voivodeship, 86-300, Poland
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Royal Blackburn Hospital
Blackburn, Blackburn WITH Darwen, BB2 3HH, United Kingdom
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SCRI Oncology Partners
Nashville, Tennessee, 37203, United States
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SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu
Opole, Opole Voivodeship, 45-061, Poland
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Sahlgrenska Universitetssjukhuset
Gothenburg, Västra Götalands LÄN [se-14], 413 45, Sweden
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Salisbury VA Medical Center
Salisbury, North Carolina, 28144, United States
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Samsung Medical Center
Seoul, Seoul-teukbyeolsi [seoul], 06351, South Korea
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Sarah Cannon Research Institute, LLC
Nashville, Tennessee, 37203, United States
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Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea
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Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [seoul], 03722, South Korea
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Shaanxi Provincial People' Hospital
Xi'an, Shaanxi, 710068, China
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Singleton Hospital
Swansea, SA2 8QA, United Kingdom
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Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310016, China
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Southern Medical University Nanfang Hospital
Guangzhou, Guangdong, 510515, China
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Stanford Cancer Center
Palo Alto, California, 94305, United States
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Stanford Health Care Attention: Investigational Pharmacy
Stanford, California, 94305, United States
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Studienpraxis Urologie
Nürtingen, Baden-Wurttemberg, 72622, Germany
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Sunnybrook Research Institute
Toronto, Ontario, M4N 3M5, Canada
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Sutter Santa Rosa
Santa Rosa, California, 95403, United States
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Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie
Krakow, Lesser Poland Voivodeship, 31-826, Poland
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Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie
Koszalin, 75-581, Poland
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Södersjukhuset
Stockholm, Stockholms LÄN [se-01], 11883, Sweden
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TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
Istanbul, İ̇stanbul, 34722, Turkey (Türkiye)
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Taichung Veterans General Hospital
Taichung, 407, Taiwan
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Taipei Veterans General Hospital
Taipei, 11217, Taiwan
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Tergooi MC
Hilversum, North Holland, 1212 VG, Netherlands
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The Beatson West of Scotland Cancer Centre
Glasgow, G12 0YN, United Kingdom
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The Centers for Advanced Urology, LLP d/b/a Keystone Urology Specialists
Lancaster, Pennsylvania, 17604, United States
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The Clatterbridge Cancer Centre
Metropolitan Borough of Wirral, CH63 4JY, United Kingdom
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The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, 325000, China
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The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, 710061, China
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The First Hospital of China Medical University
Shenyang, Liaoning, 110167, China
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The First Hospital of China Medical University
Shenyang, Liaoning, China
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The First Hospital of Jiaxing
Jiaxing, Zhejiang, 314001, China
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The Second Affiliated Hospital of Guilin Medical University
Guilin, Guangxi, 541199, China
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The Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215004, China
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The University of Louisville, James Graham Brown Cancer Center
Louisville, Kentucky, 40202, United States
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The University of Osaka Hospital
Suita, Osaka, 565-0871, Japan
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The first affiliated hospital of Ningbo university
Ningbo, Zhejiang, 315010, China
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Tongji Hospital of Tongji University
Shanghai, Shanghai Municipality, 200065, China
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UCSF Cancer Center Berkeley
Berkeley, California, 94702, United States
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UCSF Cancer Center Burlingame
Burlingame, California, 94010, United States
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UCSF Cancer Center San Mateo
San Mateo, California, 94402, United States
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UCSF Investigational Drug Pharmacy
San Francisco, California, 94158, United States
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UCSF Medical Center at Mission Bay
San Francisco, California, 94158, United States
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USA Clinical Trials
San Antonio, Texas, 78229, United States
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, 430022, China
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Universitaetsklinikum Hamburg-Eppendorf
Hamburg, 20246, Germany
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Universitaetsklinikum Tuebingen
Tübingen, Baden-Wurttemberg, 72076, Germany
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University College London Hospitals NHS Trust
London, NW1 2PG, United Kingdom
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University General Hospital "ATTIKON" - General Hospital of West Attica "H AGIA VARVARA"
Chaïdári, Attikí, 124 62, Greece
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University of Louisville Hospital
Louisville, Kentucky, 40202, United States
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University of Miami Hospital and Clinics - Doral
Doral, Florida, 33166, United States
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University of Miami Hospital and Clinics, Sylvester Cancer Center
Miami, Florida, 33136, United States
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University of Miami Hospital and Clinics, UHealth Tower
Miami, Florida, 33136, United States
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University of Miami Sylvester Comprehensive Cancer Center - Aventura
Aventura, Florida, 33180, United States
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University of Miami Sylvester Comprehensive Cancer Center - Deerfield Beach
Deerfield Beach, Florida, 33442, United States
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University of Miami Sylvester Comprehensive Cancer Center - Griffin Cancer Research Building
Miami, Florida, 33136, United States
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University of Miami Sylvester Comprehensive Cancer Center - Kendall
Kendall, Florida, 33176, United States
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University of Miami Sylvester Comprehensive Cancer Center - Plantation
Plantation, Florida, 33324, United States
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University of Miami Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center
Coral Gables, Florida, 33146, United States
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University of Washington Medical Center - Montlake
Seattle, Washington, 98195, United States
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Universitätsklinikum Münster - Albert Schweitzer Campus
Münster, North Rhine-Westphalia, 48149, Germany
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UofL Health Medical Center Northeast
Louisville, Kentucky, 40245, United States
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Urologie Neandertal - Praxis Mettmann
Mettmann, North Rhine-Westphalia, 40822, Germany
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Urology Centers of Alabama
Homewood, Alabama, 35209, United States
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VA St. Louis Health Care System
St Louis, Missouri, 63106, United States
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Vychodoslovensky onkologicky ustav, a.s.
Košice, 041 91, Slovakia
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Wannan Medical College Yijishan Hospital
Wuhu, Anhui, 241001, China
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West China Hospital, Sichuan University
Chengdu, Sichuan, 610041, China
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Western General Hospital
Edinburgh, Midlothian, EH4 2XU, United Kingdom
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Wits Clinical Research
Johannesburg, Gauteng, 2193, South Africa
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Yamagata University Hospital
Yamagata, 990-9585, Japan
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Yantai Yuhuangding Hospital
Yantai, Shandong, 264099, China
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Yokohama City University Medical Center
Yokohama, Kanagawa, 232-0024, Japan
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Yokosuka Kyosai Hospital
Yokosuka, Kanagawa, 238-8558, Japan
Conditions
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