New hope for tough prostate cancer: combo therapy aims to delay disease worsening

NCT ID NCT06551324

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 32 times

Summary

This study tests whether adding an experimental drug (PF-06821497) to standard enzalutamide works better than standard treatments alone for men with metastatic castration-resistant prostate cancer that has progressed after abiraterone. About 600 participants will be randomly assigned to receive either the combination or a standard treatment (enzalutamide or chemotherapy). The main goal is to see how long the cancer stays under control.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • 4 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ

    Wroclaw, Lower Silesian Voivodeship, 50-981, Poland

  • AUC Urologists, LLC

    Myrtle Beach, South Carolina, 29572, United States

  • Adana City Hospital

    Adana, 01370, Turkey (Türkiye)

  • AdventHealth Hematology and Oncology

    Orlando, Florida, 32804, United States

  • AdventHealth Orlando Infusion Center

    Orlando, Florida, 32804, United States

  • Alexandra General Hospital of Athens

    Athens, Attikí, 115 28, Greece

  • Althaia, Xarxa Assistencial Universitària de Manresa

    Manresa, 8423, Spain

  • Ankara University Health Practice and Research Hospitals

    Ankara, 06620, Turkey (Türkiye)

  • Arthur J.E. Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2, Canada

  • Asan Medical Center

    Seoul, Seoul-teukbyeolsi [seoul], 05505, South Korea

  • Asociación de Beneficencia Hospital Sirio Libanés

    Buenos Aires, C1419AHN, Argentina

  • Athens Medical Center

    Athens, Attikí, 151 25, Greece

  • AtlantiCare

    Egg Harbor, New Jersey, 08234, United States

  • AtlantiCare Health Park - Cape May Court House

    Cape May Court House, New Jersey, 08210, United States

  • BC Cancer Vancouver

    Vancouver, British Columbia, V5Z 4E6, Canada

  • BEKY - MED, s.r.o.

    Prešov, 080 01, Slovakia

  • Beijing Friendship Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100050, China

  • CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia

    Santo André, São Paulo, 09060-650, Brazil

  • CHRU de Brest

    Brest, Finistère, 29200, France

  • Canisius-Wilhelmina Ziekenhuis

    Nijmegen, Gelderland, 6532 SZ, Netherlands

  • Carolina Urologic Research Center, LLC

    Myrtle Beach, South Carolina, 29572, United States

  • Centre Antoine Lacassagne

    Nice, Alpes-maritimes, 06189, France

  • Centre Antoine-Lacassagne

    Nice, Alpes-maritimes, 06189, France

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, Rhône, 69310, France

  • Centre Hospitalier Privé Saint-Grégoire

    Saint-Grégoire, Ille-et-vilaine, 35760, France

  • Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire

    Nîmes, GARD, 30029, France

  • Centre Hospitalier de l'Université de Montréal

    Montreal, Quebec, H2X 3E4, Canada

  • Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne

    Clermont-Ferrand, 63011, France

  • Centre Leon Berard

    Lyon Cedex08, Auvergne-Rhône-Alpes, 69373, France

  • Centre Oscar Lambret

    Lille, Hauts-de-France, 59020, France

  • Centro Medico Privado CEMAIC

    Capital, Córdoba Province, X5008HHW, Argentina

  • Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)

    Buenos Aires, C1431FWO, Argentina

  • Centro de Urología (CDU)

    CABA, Buenos Aires, C1120AAT, Argentina

  • Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o.

    Krakow, Lesser Poland Voivodeship, 30-348, Poland

  • Chang Gung Medical Foundation-Linkou Branch

    Taoyuan, 333, Taiwan

  • Chiba cancer center

    Chiba, Chiba, 260-8717, Japan

  • Chongqing University Cancer Hospital

    Chongqing, Chongqing Municipality, 400030, China

  • Chonnam National University Hwasun Hospital

    Hwasun, Jeonranamdo, 58128, South Korea

  • Circuit Clinical

    Middletown, New York, 10941, United States

  • Circuit Clinical /Crystal Run Healthcare LLP

    Middletown, New York, 10941, United States

  • Colorado Clinical Research

    Lakewood, Colorado, 80228, United States

  • Crio - Centro Regional Integrado de Oncologia

    Fortaleza, Ceará, 60336232, Brazil

  • Crystal Run Healthcare

    Monroe, New York, 10950, United States

  • Duly Health and Care

    Lisle, Illinois, 60532, United States

  • Duly Health and Care

    Westmont, Illinois, 60559, United States

  • Ewha Womans University Mokdong Hospital

    Seoul, Seoul-teukbyeolsi [seoul], 07985, South Korea

  • Fakultna nemocnica Trnava

    Trnava, 917 02, Slovakia

  • Fakultni Thomayerova nemocnice

    Prague, Praha 4, 14059, Czechia

  • Fakultni nemocnice Kralovske Vinohrady

    Prague, Praha 10, 10034, Czechia

  • Fakultni nemocnice Olomouc

    Olomouc, Olomouc Region, 779 00, Czechia

  • Florida Cancer Specialists

    Bonita Springs, Florida, 34135, United States

  • Florida Cancer Specialists

    Bradenton, Florida, 34211, United States

  • Florida Cancer Specialists

    Cape Coral, Florida, 33909, United States

  • Florida Cancer Specialists

    Fort Myers, Florida, 33905, United States

  • Florida Cancer Specialists

    Fort Myers, Florida, 33908, United States

  • Florida Cancer Specialists

    N. Venice, Florida, 34275, United States

  • Florida Cancer Specialists

    Naples, Florida, 34102, United States

  • Florida Cancer Specialists

    Port Charlotte, Florida, 33980, United States

  • Florida Cancer Specialists

    Sarasota, Florida, 34236, United States

  • Fred Hutchinson Cancer Center

    Seattle, Washington, 98109, United States

  • Frisius Medisch Centrum

    Leeuwarden, Provincie Friesland, 8934 AD, Netherlands

  • Fujian Cancer Hospital

    Fuzhou, Fujian, 350014, China

  • Fujian Medical University Union Hospital

    Fuzhou, Fujian, 350001, China

  • Fundação Faculdade Regional de Medicina de São José do Rio Preto

    São José do Rio Preto, São Paulo, 15090000, Brazil

  • Gazi University Health Research and Application Center Gazi Hospital

    Ankara, 06560, Turkey (Türkiye)

  • Grand Strand Medical Center

    Myrtle Beach, South Carolina, 29572, United States

  • Guangzhou First People's Hospital

    Guangzhou, Guangdong, 510180, China

  • Gulhane Egitim Arastirma Hastanesi

    Ankara, 06010, Turkey (Türkiye)

  • Gustave Roussy

    Villejuif, Val-de-marne, 94800, France

  • Harborview Medical Center

    Seattle, Washington, 98104, United States

  • Hokkaido University Hospital

    Sapporo, Hokkaido, 060-8648, Japan

  • Hopitaux Universitaire de Strasbourg - Hopital Hautepierre

    Strasbourg, Bas-rhin, 67091, France

  • Hospital Alemao Oswaldo Cruz

    São Paulo, São Paulo, 01327-001, Brazil

  • Hospital Clínic de Barcelona

    Barcelona, Catalunya [cataluña], 08036, Spain

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007, Spain

  • Hospital São Carlos

    Fortaleza, Ceará, 60135-237, Brazil

  • Hospital São Lucas da PUCRS

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Hospital Universitari i Politecnic La Fe

    Valencia, 46026, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, Madrid, Comunidad de, 28041, Spain

  • Hospital Universitario Fundación Jiménez Díaz

    Madrid, 28040, Spain

  • Hospital Universitario HM Sanchinarro

    Madrid, 28050, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, Madrid, Comunidad de, 28034, Spain

  • Hospital de Base de São José do Rio Preto

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Catalunya [cataluña], 08041, Spain

  • Huai'an First People's Hospital

    Huai'an, Jiangsu, 223300, China

  • Hunan Cancer Hospital

    Changsha, Hunan, 410013, China

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • Hôpital Foch

    Suresnes, Hauts-de-seine, 92151, France

  • I.E.U. Medical Point Hastanesi

    Cordaleo, İzmir, 35575, Turkey (Türkiye)

  • IBCC - Núcleo de Pesquisa e Ensino

    São Paulo, 04014-002, Brazil

  • IMAXE

    Buenos Aires, C1120, Argentina

  • IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"

    Meldola, Emilia-Romagna, 47014, Italy

  • Icon Cancer Centre Wesley

    Auchenflower, Queensland, 4066, Australia

  • Imagenes Mdq

    Mar del Plata, Buenos Aires, 7600, Argentina

  • Institut Català d'Oncologia - L'Hospitalet

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • Institut Jean Godinot

    Reims, Marne, 51726, France

  • Instituto Alexander Fleming

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

  • Instituto de Investigaciones Clínicas Mar del Plata

    Mar del Plata, Buenos Aires, B7600FZO, Argentina

  • Instituto do Cancer Arnaldo Vieira de Carvalho

    São Paulo, 01221-020, Brazil

  • Ironwood Cancer & Research Centers

    Chandler, Arizona, 85224, United States

  • Ironwood Cancer & Research Centers

    Gilbert, Arizona, 85297, United States

  • Ironwood Cancer & Research Centers

    Glendale, Arizona, 85306, United States

  • Ironwood Cancer & Research Centers

    Mesa, Arizona, 85202, United States

  • Ironwood Cancer & Research Centers

    Mesa, Arizona, 85206, United States

  • Ironwood Cancer & Research Centers

    Phoenix, Arizona, 85028, United States

  • Ironwood Cancer & Research Centers

    Scottsdale, Arizona, 85260, United States

  • Istanbul Universitesi Cerrahpasa

    Istanbul, İ̇stanbul, 34668, Turkey (Türkiye)

  • Istituto Nazionale Tumori Regina Elena

    Rome, Lazio, 00144, Italy

  • James J. Peters VA Medical Center

    The Bronx, New York, 10468, United States

  • Kanazawa University Hospital

    Kanazawa, Ishikawa-ken, 920-8641, Japan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807, Taiwan

  • Keio university hospital

    Shinjuku-ku, Tokyo, 1608582, Japan

  • Kobe University Hospital

    Kobe, Hyōgo, 650-0017, Japan

  • Koç Üniversitesi Hastanesi

    Istanbul, İ̇stanbul, 34010, Turkey (Türkiye)

  • Kyungpook National University Chilgok Hospital

    Daegu, Taegu-kwangyǒkshi, 41404, South Korea

  • Lanzhou university second hospital

    Lanzhou, Gansu, 730030, China

  • Los Angeles Cancer Network

    Anaheim, California, 92801, United States

  • Los Angeles Cancer Network

    Fountain Valley, California, 92708, United States

  • Los Angeles Cancer Network

    Glendale, California, 91204, United States

  • Los Angeles Cancer Network

    Glendale, California, 91206, United States

  • Los Angeles Cancer Network

    Los Angeles, California, 90017, United States

  • Los Angeles Cancer Network

    Los Angeles, California, 90067, United States

  • MICS Centrum Medyczne Torun

    Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland

  • MILAB, s.r.o., Urologicka ambulancia

    Prešov, 08 001, Slovakia

  • Marmara Universitesi Pendik Egitim Arastirma Hastanesi

    Istanbul, İ̇stanbul, 34899, Turkey (Türkiye)

  • Meander Medisch Centrum

    Amersfoort, Utrecht, 3813 TZ, Netherlands

  • Memorial Ankara Hastanesi

    Ankara, 06520, Turkey (Türkiye)

  • Metropolitan General Hospital

    Athens, Attikí, 155 62, Greece

  • Mid and South Essex NHS Foundation Trust

    Westcliff-on-Sea, Essex, SS0 0RY, United Kingdom

  • Monash Health

    Clayton, Victoria, 3168, Australia

  • Multiscan

    Pardubice, Pardubice Region, 53203, Czechia

  • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

    Nanjing, Jiangsu, 210000, China

  • Nantong Tumor Hospital

    Nantong, Jiangsu, 226361, China

  • National Cancer Center

    Goyang-si, Kyǒnggi-do, 10408, South Korea

  • National Cancer Center Hospital East

    Kashiwa, Chiba, 277-8577, Japan

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Hospital Organization Hokkaido Cancer Center

    Sapporo, Hokkaido, 003-0804, Japan

  • National Hospital Organization Kumamoto Medical Center

    Kumamoto, 860-0008, Japan

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, 811-1395, Japan

  • National Hospital Organization Shikoku Cancer Center

    Matsuyama, Ehime, 791-0280, Japan

  • National Taiwan University Hospital

    Taipei, 100225, Taiwan

  • New England Cancer Specialists

    Topsham, Maine, 04086, United States

  • New England Cancer Specialists

    Westbrook, Maine, 04092, United States

  • NextStage Clinical Research-Chicago-(04)

    Lisle, Illinois, 60532, United States

  • Nukleární Medicína

    Hradec Králové, 500 05, Czechia

  • Oncopole Claudius Regaud

    Toulouse, Haute-garonne, 31059, France

  • Országos Onkológiai Intézet

    Budapest, Pest County, 1122, Hungary

  • Osaka International Cancer Institute

    Osaka, 541-8567, Japan

  • Ospedale San Raffaele

    Milan, 20132, Italy

  • Parkway Surgery Center

    Myrtle Beach, South Carolina, 29572, United States

  • Peking University Third Hospital

    Beijing, Beijing Municipality, 100191, China

  • Peter MacCallum Cancer Centre

    Melbourne, Victoria, 3000, Australia

  • Petz Aladar Egyetemi Oktato Korhaz

    Győr, Győr-Moson-Sopron, 9024, Hungary

  • Radiodiagnostika Pardubice

    Pardubice, 53003, Czechia

  • Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego

    Grudziądz, Kuyavian-Pomeranian Voivodeship, 86-300, Poland

  • Royal Blackburn Hospital

    Blackburn, Blackburn WITH Darwen, BB2 3HH, United Kingdom

  • SCRI Oncology Partners

    Nashville, Tennessee, 37203, United States

  • SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu

    Opole, Opole Voivodeship, 45-061, Poland

  • Sahlgrenska Universitetssjukhuset

    Gothenburg, Västra Götalands LÄN [se-14], 413 45, Sweden

  • Salisbury VA Medical Center

    Salisbury, North Carolina, 28144, United States

  • Samsung Medical Center

    Seoul, Seoul-teukbyeolsi [seoul], 06351, South Korea

  • Sarah Cannon Research Institute, LLC

    Nashville, Tennessee, 37203, United States

  • Seoul National University Hospital

    Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, Seoul-teukbyeolsi [seoul], 03722, South Korea

  • Shaanxi Provincial People' Hospital

    Xi'an, Shaanxi, 710068, China

  • Singleton Hospital

    Swansea, SA2 8QA, United Kingdom

  • Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310016, China

  • Southern Medical University Nanfang Hospital

    Guangzhou, Guangdong, 510515, China

  • Stanford Cancer Center

    Palo Alto, California, 94305, United States

  • Stanford Health Care Attention: Investigational Pharmacy

    Stanford, California, 94305, United States

  • Studienpraxis Urologie

    Nürtingen, Baden-Wurttemberg, 72622, Germany

  • Sunnybrook Research Institute

    Toronto, Ontario, M4N 3M5, Canada

  • Sutter Santa Rosa

    Santa Rosa, California, 95403, United States

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie

    Krakow, Lesser Poland Voivodeship, 31-826, Poland

  • Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie

    Koszalin, 75-581, Poland

  • Södersjukhuset

    Stockholm, Stockholms LÄN [se-01], 11883, Sweden

  • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

    Istanbul, İ̇stanbul, 34722, Turkey (Türkiye)

  • Taichung Veterans General Hospital

    Taichung, 407, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • Tergooi MC

    Hilversum, North Holland, 1212 VG, Netherlands

  • The Beatson West of Scotland Cancer Centre

    Glasgow, G12 0YN, United Kingdom

  • The Centers for Advanced Urology, LLP d/b/a Keystone Urology Specialists

    Lancaster, Pennsylvania, 17604, United States

  • The Clatterbridge Cancer Centre

    Metropolitan Borough of Wirral, CH63 4JY, United Kingdom

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, Zhejiang, 325000, China

  • The First Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, Shaanxi, 710061, China

  • The First Hospital of China Medical University

    Shenyang, Liaoning, 110167, China

  • The First Hospital of China Medical University

    Shenyang, Liaoning, China

  • The First Hospital of Jiaxing

    Jiaxing, Zhejiang, 314001, China

  • The Second Affiliated Hospital of Guilin Medical University

    Guilin, Guangxi, 541199, China

  • The Second Affiliated Hospital of Soochow University

    Suzhou, Jiangsu, 215004, China

  • The University of Louisville, James Graham Brown Cancer Center

    Louisville, Kentucky, 40202, United States

  • The University of Osaka Hospital

    Suita, Osaka, 565-0871, Japan

  • The first affiliated hospital of Ningbo university

    Ningbo, Zhejiang, 315010, China

  • Tongji Hospital of Tongji University

    Shanghai, Shanghai Municipality, 200065, China

  • UCSF Cancer Center Berkeley

    Berkeley, California, 94702, United States

  • UCSF Cancer Center Burlingame

    Burlingame, California, 94010, United States

  • UCSF Cancer Center San Mateo

    San Mateo, California, 94402, United States

  • UCSF Investigational Drug Pharmacy

    San Francisco, California, 94158, United States

  • UCSF Medical Center at Mission Bay

    San Francisco, California, 94158, United States

  • USA Clinical Trials

    San Antonio, Texas, 78229, United States

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei, 430022, China

  • Universitaetsklinikum Hamburg-Eppendorf

    Hamburg, 20246, Germany

  • Universitaetsklinikum Tuebingen

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • University College London Hospitals NHS Trust

    London, NW1 2PG, United Kingdom

  • University General Hospital "ATTIKON" - General Hospital of West Attica "H AGIA VARVARA"

    Chaïdári, Attikí, 124 62, Greece

  • University of Louisville Hospital

    Louisville, Kentucky, 40202, United States

  • University of Miami Hospital and Clinics - Doral

    Doral, Florida, 33166, United States

  • University of Miami Hospital and Clinics, Sylvester Cancer Center

    Miami, Florida, 33136, United States

  • University of Miami Hospital and Clinics, UHealth Tower

    Miami, Florida, 33136, United States

  • University of Miami Sylvester Comprehensive Cancer Center - Aventura

    Aventura, Florida, 33180, United States

  • University of Miami Sylvester Comprehensive Cancer Center - Deerfield Beach

    Deerfield Beach, Florida, 33442, United States

  • University of Miami Sylvester Comprehensive Cancer Center - Griffin Cancer Research Building

    Miami, Florida, 33136, United States

  • University of Miami Sylvester Comprehensive Cancer Center - Kendall

    Kendall, Florida, 33176, United States

  • University of Miami Sylvester Comprehensive Cancer Center - Plantation

    Plantation, Florida, 33324, United States

  • University of Miami Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center

    Coral Gables, Florida, 33146, United States

  • University of Washington Medical Center - Montlake

    Seattle, Washington, 98195, United States

  • Universitätsklinikum Münster - Albert Schweitzer Campus

    Münster, North Rhine-Westphalia, 48149, Germany

  • UofL Health Medical Center Northeast

    Louisville, Kentucky, 40245, United States

  • Urologie Neandertal - Praxis Mettmann

    Mettmann, North Rhine-Westphalia, 40822, Germany

  • Urology Centers of Alabama

    Homewood, Alabama, 35209, United States

  • VA St. Louis Health Care System

    St Louis, Missouri, 63106, United States

  • Vychodoslovensky onkologicky ustav, a.s.

    Košice, 041 91, Slovakia

  • Wannan Medical College Yijishan Hospital

    Wuhu, Anhui, 241001, China

  • West China Hospital, Sichuan University

    Chengdu, Sichuan, 610041, China

  • Western General Hospital

    Edinburgh, Midlothian, EH4 2XU, United Kingdom

  • Wits Clinical Research

    Johannesburg, Gauteng, 2193, South Africa

  • Yamagata University Hospital

    Yamagata, 990-9585, Japan

  • Yantai Yuhuangding Hospital

    Yantai, Shandong, 264099, China

  • Yokohama City University Medical Center

    Yokohama, Kanagawa, 232-0024, Japan

  • Yokosuka Kyosai Hospital

    Yokosuka, Kanagawa, 238-8558, Japan

Conditions

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