Could a common arthritis drug replace risky steroids for leprosy pain?

NCT ID NCT03775460

Ongoing Disease control Sponsor: London School of Hygiene and Tropical Medicine Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 30 times

Summary

This study tests whether methotrexate, a low-cost drug, can help control Erythema Nodosum Leprosum (ENL)—a painful complication of leprosy—while reducing the need for high-dose steroids that cause serious side effects. About 550 adults with active ENL will receive either methotrexate plus prednisolone or prednisolone alone. The goal is to see if methotrexate keeps ENL flares away longer and with less steroid use.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

ALERT

Addis Ababa, Ethiopia
Anandaban Hospital

Kathmandu, Nepal
Bombay Leprosy Project

Mumbai, India
FIOCRUZ

Rio de Janeiro, Brazil
Soetomo Hospital

Surabaya, Indonesia
TMLI Bangladesh/ DBLM hospital

Dhaka, Bangladesh
The Leprosy Mission Trust

Delhi, India

Conditions

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ERYTHEMA NODOSUM LEPROSUM