Painkiller methadone joins chemo in fight against hard-to-treat colon cancer
NCT ID NCT05212012
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether adding the painkiller D,L-methadone to standard chemotherapy (mFOLFOX6) can help control advanced colorectal cancer that has stopped responding to other treatments. The study has two parts: first, finding a safe dose of methadone; second, comparing disease control at 12 weeks between the combination and chemo alone. Only 11 participants are enrolled, so results are very preliminary.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
D,L-methadone (a painkiller) plus mFOLFOX6 (a chemotherapy combination)
What this could lead to
If it works, this could offer a new treatment option for people with advanced colorectal cancer that has stopped responding to standard therapies.
What could go wrong
This is a very early, small trial (only 11 participants) testing safety and dosing. It may not show meaningful benefit, and methadone has risks like addiction and breathing problems.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Stauferklinikum Schwäbisch Gmünd
Mutlangen, 73557, Germany
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Universitätsklinikum Hamburg Eppendorf - II. Med.
Hamburg, 20246, Germany
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Universitätsklinikum Ulm - Innere Med. I
Ulm, 89081, Germany