Diabetes drug metformin may help keep leukemia in remission

NCT ID NCT07188740

First seen Oct 31, 2025 · Last updated May 14, 2026 · Updated 25 times

Summary

This early-phase study tests whether metformin, a common diabetes medicine, can reduce levels of a specific gene mutation (DNMT3A R882) in 30 adults with acute leukemia who are in remission. Participants take metformin pills for 6 months. The goal is to see if the mutation drops enough to lower the chance of leukemia returning. This is not a cure, but a way to control the disease and prevent relapse.

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