Can a melatonin pill calm surgery stress better than IV drugs?
NCT ID NCT07568873
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether taking oral melatonin before sinus surgery could reduce the body's stress response and improve the surgical field, compared to two intravenous drugs (metoprolol and dexmedetomidine) or a placebo. It involved 28 adults undergoing elective functional endoscopic sinus surgery. Researchers measured changes in blood pressure, heart rate, and surgeon satisfaction with the operating conditions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Melatonin, Metoprolol, Dexmedetomidine
- What this could lead to
- If successful, this could point to a simple, low-cost way to reduce stress during surgery and improve conditions for the surgeon.
- What could go wrong
- This is a small, completed trial with only 28 participants, so results may not apply broadly. The drugs also carry risks like low blood pressure or slow heart rate.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Faculty of Medicine, Zagazig Univeristy
Zagazig, Sharqia Province, 44519, Egypt