Can a melatonin pill calm surgery stress better than IV drugs?
NCT ID NCT07568873
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether taking oral melatonin before sinus surgery could reduce the body's stress response and improve the surgical field, compared to two intravenous drugs (metoprolol and dexmedetomidine) or a placebo. It involved 28 adults undergoing elective functional endoscopic sinus surgery. Researchers measured changes in blood pressure, heart rate, and surgeon satisfaction with the operating conditions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Melatonin, Metoprolol, Dexmedetomidine
What this could lead to
If successful, this could point to a simple, low-cost way to reduce stress during surgery and improve conditions for the surgeon.
What could go wrong
This is a small, completed trial with only 28 participants, so results may not apply broadly. The drugs also carry risks like low blood pressure or slow heart rate.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Faculty of Medicine, Zagazig Univeristy
Zagazig, Sharqia Province, 44519, Egypt