Can a common Motion-Sickness drug tame vertigo as well as the standard?

NCT ID NCT02112578

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This trial tests whether meclizine, a drug often used for motion sickness, works as well as dimenhydrinate for controlling acute vertigo symptoms that come from inner-ear problems. Adults aged 18 to 64 with moderate to severe vertigo take one of the two drugs three times a day for up to 30 days. Researchers track symptom scores, quality of life, and daytime sleepiness to see if meclizine is a suitable alternative.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
meclizine (an antihistamine) compared with dimenhydrinate (another antihistamine)
What this could lead to
If meclizine works as well as dimenhydrinate, it could offer another option for quickly easing vertigo symptoms with possibly less daytime sleepiness.
What could go wrong
This is a phase 3 trial, but success is not guaranteed. The drugs may prove unequal in effect, and side effects like drowsiness could still be a problem.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

292 people

The number who actually took part.

Started

Nov 2016

Finished

Dec 2017

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women aged over 18 years and less than 65; * Presence of vertigo episodes of vestibular origin (peripheral ) of moderate intensity , strong or very strong according to the VS range ; * Participants who are able to swallow tablets / capsules; * Participants able to understand the guidance and care of this study and cooperative ; * Participants with the requisite understanding, in accordance with Good Clinical Practice Research Document of the Americas. Exclusion Criteria: * Use of meclizine or dimenidrynate in the actual event or in the past 15 days; * Use of alcohol in the past 48 hours; * Presence of vomiting which prevent the ingestion of tablets; * Pregnancy or breastfeeding; * Presence of clinical condition that determines contraindication to the active substances : convulsions , suspected intracranial compressive processes , closed-angle glaucoma , prostatic adenoma with urinary disorders , liver diseases , endocrine , renal, and / or uncontrolled cardiovascular , Parkinson's disease, porphyria, know history of hipersensibility to the Actives or Excipients from the study medications; * Malignancies History , even if no evidence of active disease for less than five years . Those without active disease for more than five years may be included; * Uncontrolled systemic arterial hypertension ( \> 140/90 mmHg ); * Decompensated diabetes mellitus (blood glucose at any time \> 200 mg / dL ); * Participants with asthma or chronic obstructive pulmonary disease; * Participants making use of antihistamines with anti-vertigo effect ( betahistine, meclizine , diphenidol ) , drugs with antagonist calcium channel action ( cinnarizine , flunarizine ) , anticholinergic drugs ( metoclopramide , dimenhydrinate , meclizine , diphenidol , scopolamine, ondansetron, granisetron ) , antiseizure drugs ( diazepam , clonazepam , carbamazepine ) and other central nervous system depressants; * Participants with central origin vertigo or non-vestibular; * Participants with positional benign positional paroxysmal vertigo (bppv).

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Vertigo, peripheral are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Alergoalpha

    Barueri, São Paulo, 06454010, Brazil

  • CCBR SP

    São Paulo, São Paulo, 04063001, Brazil

  • Clinica de Alergia MarttiAntila

    Sorocaba, São Paulo, 18040425, Brazil

  • Clinilive

    Maringá, Paraná, Brazil

  • ISPEM

    São José dos Campos, São Paulo, 12243280, Brazil

  • Irmandade da Santa Casa de Misericórdia de São Paulo

    São Paulo, São Paulo, Brazil

  • Pesquisare Saude S/S Ltda

    Santo André, São Paulo, 09080110, Brazil