New pill shows promise for tough lymphoma in japanese study
NCT ID NCT04533581
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This phase 2 study tests an oral drug called ME-401 in 61 Japanese adults with a slow-growing form of non-Hodgkin's lymphoma that has returned or not responded to at least two prior treatments. The drug is taken daily for the first two months, then on a weekly schedule. Researchers are checking how well it shrinks tumors and how safe it is.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ME-401 (a PI3K inhibitor taken orally)
What this could lead to
If successful, this could provide a new treatment option for Japanese patients with a hard-to-treat form of lymphoma that has come back after other therapies.
What could go wrong
This is a small, early-phase study (61 people) with no comparison group. The drug may not work well enough or could cause side effects. It is also limited to Japanese patients, so results may not apply to other populations.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aichi Cancer Center Hospital
Nagoya, Aichi-ken, Japan
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Akita University Hospital
Akita, Japan
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Anjo Kosei Hospital
Anjo, Aichi-ken, Japan
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Aomori Prefectural Central Hospital
Aomori, Japan
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Chiba Cancer Center
Chiba, Japan
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Chugoku Central Hospital
Fukuyama, Hiroshima, Japan
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Gunma University Hospital
Maebashi, Gunma, Japan
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Hokkaido University Hospital
Sapporo, Hokkaido, Japan
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Ishikawa Prefectural Central Hospital
Kanazawa, Ishikawa-ken, Japan
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Japanese Red Cross Kyoto Daini Hospital
Kyoto, Japan
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Japanese Red Cross Nagoya Daini Hospital
Nagoya, Aichi-ken, Japan
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Jichi Medical University Hospital
Shimotsuke, Tochigi, Japan
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Kagoshima University Hospital
Kagoshima, Japan
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Kameda Medical Center
Kamogawa, Chiba, Japan
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Kindai University Hospital
Sayama, Osaka, Japan
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Kurashiki Central Hospital
Kurashiki, Okayama-ken, Japan
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Kyushu University Hospital
Fukuoka, Japan
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Mie University Hospital
Tsu, Mie-ken, Japan
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National Cancer Center Hospital
Chuo-ku, Tokyo, Japan
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National Hospital Organization Kumamoto Medical Center
Kumamoto, Japan
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National Hospital Organization Kyushu Medical Center
Fukuoka, Japan
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National Hospital Organization Nagoya Medical Center
Nagoya, Aichi-ken, Japan
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National Hospital Organization Shikoku Cancer Center
Matsuyama, Ehime, Japan
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Okayama University Hospital
Okayama, Japan
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Osaka University Hospital
Suita, Osaka, Japan
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Saitama Medical University International Medical Center
Hidaka, Saitama, Japan
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The Cancer Institute Hospital Of JFCR
Koto-ku, Tokyo, Japan
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Tohoku University Hospital
Sendai, Miyagi, Japan
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Tokyo Metropolitan Komagome Hospital
Bunkyo-ku, Tokyo, Japan
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Tottori University Hospital
Yonago, Tottori, Japan