New pill shows promise for Hard-to-Treat blood cancer in early japanese study
NCT ID NCT03985189
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tested a new oral drug called ME-401 in 14 Japanese patients with a slow-growing form of non-Hodgkin's lymphoma that had returned or stopped responding to prior treatments. The main goals were to check the drug's safety, find the right dose, and see how the body processes it. Researchers also offered a roll-over option for continued treatment and safety monitoring.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ME-401 (a PI3K inhibitor taken orally)
- What this could lead to
- If successful, this could lead to a new treatment option for Japanese patients with a type of blood cancer that has come back or not responded to other therapies.
- What could go wrong
- This is a very early, small Phase 1 trial with only 14 participants, focused on safety and dosing. It is not designed to prove effectiveness, and the drug may cause side effects or fail in larger studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aomori Prefectural Central Hospital
Aomori, 030-8553, Japan
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Hokkaido University Hospital
Sapporo, Hokkaido, 060-0814, Japan
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Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
Nagoya, Aichi-ken, 466-8650, Japan
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Kyushu University Hospital
Fukuoka, 812-8582, Japan
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National Cancer Center Hospital
Chuo-ku, Tokyo, 104-0045, Japan
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National Hospital Organization Nagoya Medical Center
Nagoya, Aichi-ken, 460-0001, Japan
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Okayama University Hospital
Okayama, 700-8558, Japan
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The Cancer Institute Hospital of JFCR
Koto-ku, Tokyo, 135-8550, Japan
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Tokyo Metropolitan Komagome Hospital
Bunkyo-ku, Tokyo, 113-8677, Japan