New drug targets fatty liver in people with 'fat gene' variant
NCT ID NCT05395481
First seen Nov 01, 2025 · Last updated May 17, 2026 · Updated 26 times
Summary
This early-stage study tests a new medicine called LY3849891 in people with fatty liver disease (MASLD) who have a specific gene change (PNPLA3 I148M). The main goal is to check the drug's safety and how the body processes it. Researchers will also use blood tests and liver scans to see if the drug reduces liver fat and inflammation. The study involves up to 176 adults and lasts up to 32 weeks.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Accel Research Sites - Maitland
Maitland, Florida, 32751, United States
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Advanced Pharma Clinical Research
Miami, Florida, 33175, United States
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Arizona Liver Health - Chandler
Chandler, Arizona, 85225, United States
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Charter Research - Winter Park
Orlando, Florida, 32803, United States
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Clinical Research Hospital Tokyo
Shinjuku-ku, 160-0004, Japan
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Clinical Trials of Texas, Inc.
San Antonio, Texas, 78229, United States
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Evolution Clinical Trials, Inc
Miami, Florida, 33122, United States
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FDI Clinical Research
San Juan, 00927, Puerto Rico
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Floridian Clinical Research
Miami Lakes, Florida, 33016, United States
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Houston Research Institute
Houston, Texas, 77079, United States
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IU Health University Hospital
Indianapolis, Indiana, 46290, United States
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Inland Empire Clinical Trials, LLC
Rialto, California, 92377, United States
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Orange County Research Center
Orange, California, 92868, United States
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P-One Clinic
Hachiōji, 192-0071, Japan
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Pinnacle Clinical Research
San Antonio, Texas, 78229, United States
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Synergy Healthcare LLC
Brandon, Florida, 33511, United States
Conditions
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