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Fifteen minutes vs thirty: which timing for placenta removal saves more blood?

NCT ID NCT03626844

Disease control Sponsor: Holy Family Hospital, Nazareth, Israel Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Aug 18, 2026 · Updated 3 times

Summary

This trial compares removing the placenta manually 15 minutes after birth versus the usual 30 minutes. The goal is to see if acting sooner reduces blood loss and improves maternal outcomes like infection rates and breastfeeding timing. The study includes 100 women with uncomplicated vaginal deliveries and epidural pain relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Manual lysis of placenta (procedure)
What this could lead to
If waiting 15 minutes proves better, it could become standard practice to reduce blood loss and improve recovery after childbirth.
What could go wrong
This is a small, single-center trial, so results may not apply to all hospitals or births. The difference between 15 and 30 minutes may be too small to matter.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Term spontaneous vaginal delivery. * Singleton Pregnancy. * Epidural Analgesia during delivery. * Age between 18 and 45 years. Exclusion Criteria: * Active bleeding after delivery that warrants prompt removal of placenta regardless of time from delivery. * Vacuum Extraction. * Intrapartum Infection. * Intrapartum fever above 38 degrees celsius. * Wide 3rd and 4th degree perineal tears that mandate suturing under general anaesthesia. * Thalassemia Carriers.

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Conditions

The condition(s) this trial relates to.

Postpartum Hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Third stage of delivery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Holy Family Hospital

    RECRUITING

    Nazareth, Israel