New drug combo shows promise for rare lymphoma

NCT ID NCT01808599

First seen Jan 16, 2026 · Last updated May 14, 2026 · Updated 18 times

Summary

This study tested a combination of two drugs, chlorambucil (a chemotherapy pill) and rituximab (an antibody given as a shot under the skin), followed by maintenance rituximab, in 112 people with MALT lymphoma, a slow-growing cancer of the lymph system. The goal was to see how many patients achieved complete remission (no signs of cancer). Participants had either newly diagnosed or relapsed MALT lymphoma that was CD20-positive. The approach aims to control the disease, but ongoing management may be needed.

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Contacts and locations

Locations

  • AO SS. Antonio e Biagio e Cesare Arrigo

    Alessandria, Italy

  • ARNAS Garibaldi Catania

    Catania, Italy

  • Ancona

    Ancona, Italy

  • Arcispedale Santa Maria Nuova, Azienda Ospedaliera di Reggio Emilia

    Reggio Emilia, Italy

  • Azienda Ospedaliero-Universitaria di Parma

    Parma, Italy

  • Azienda Sanitaria AUSL6 Livorno

    Livorno, Italy

  • Biella Ospedale degli Infermi

    Biella, Italy

  • Centro di Riferimento Oncologico di Aviano

    Aviano, Italy

  • Clermont Ferrand CHU Estaing

    Estaing, France

  • Créteil Hopital Henri Mondor

    Créteil, France

  • Dijon CHU Hopital le Bocage

    Dijon, France

  • Ematologia Ospedale Businco (Cagliari)

    Cagliari, Italy

  • Ematologia e CTMO Ospedale Bolzano

    Bolzano, Italy

  • Genova Ematologia I H San Martino

    Genova, Italy

  • Grenoble CHU Pontchaillou

    Grenoble, France

  • IOSI - Oncology Institute of Southern Switzerland

    Bellinzona, 6500, Switzerland

  • IOV Padova

    Padova, Italy

  • IRCCS/CROB Rionero in Vulture

    Rionero in Vulture, Italy

  • Istituto Nazionale dei Tumori, Milano

    Milan, Italy

  • Istituto Regina Elena, Roma, IFO

    Roma, Italy

  • Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

    Meldola, Italy

  • Lille CHRU Hopital Claude Dieu

    Lille, France

  • Marseille Paoli Calmettes

    Marseille, France

  • Milano Ospedale Policlinico

    Milan, Italy

  • Montpellier CHU Saint Eloi

    Montpellier, France

  • Nantes CHU Hotel Dieu

    Nantes, France

  • Nocera

    Nocera Umbra, Italy

  • Ospedale Infermi Ematologia Rimini

    Rimini, Italy

  • Paris Hopital Saint Louis

    Paris, France

  • Pierre Bénite CHU Lyon Sud

    Lyon, France

  • Rennes CHU Pontchaillou

    Rennes, France

  • Rouen Centre Henri Becquerel

    Rouen, France

  • SC Ematologia Torino-Molinette

    Torino, Italy

  • SC Oncoematologia Terni

    Terni, Italy

  • Torino Università, Ematologia 1, AO Città della Salute e della Scienza

    Torino, Italy

  • Tours CHU Bretonneau

    Tours, France

  • UO Ematologia Ravenna

    Ravenna, Italy

  • Vandoeuvre lès Nancy CHU Brabois

    Nancy, France

Conditions

Explore the condition pages connected to this study.