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Comparative effects of diode laser and LED photobiomodulation on maxillary canine retraction during orthodontic treatment

NCT ID NCT07810699

NEW Sponsor: Can Tho University of Medicine and Pharmacy Source: ClinicalTrials.gov ↗

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First seen Sep 09, 2026 · Last updated Sep 09, 2026

Summary

This study aims to compare the effects of diode laser and light-emitting diode (LED) photobiomodulation on maxillary canine retraction during fixed orthodontic treatment. Participants requiring bilateral maxillary first premolar extraction will receive both interventions using a split-mouth design. One maxillary canine will receive diode laser photobiomodulation, while the contralateral maxillary canine will receive LED photobiomodulation. Maxillary canine movement will be evaluated at 4, 8, 12, and 16 weeks during retraction to compare the amount and rate of tooth movement between the two interventions. Pain associated with orthodontic tooth movement will also be assessed. Pulp oxygen saturation (SpO₂) of the maxillary canines will be measured to evaluate changes in pulpal oxygenation during orthodontic canine retraction. SpO₂ will be assessed at baseline and at predefined follow-up time points, including 20 minutes, 24 hours, 7 days, and 4 weeks. Changes in SpO₂ will be compared between the diode laser and LED sides. Cone-beam computed tomography (CBCT) will be used to evaluate changes in maxillary canine root length and alveolar bone dimensions before and after canine retraction. The study is expected to determine whether diode laser and LED photobiomodulation differ in their effects on orthodontic canine retraction, pulpal oxygenation, pain, and associated dental and alveolar bone changes.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with complete permanent dentition and cervical vertebral maturation at CS5 or CS6 according to the Baccetti classification. * Angle Class I malocclusion. * Indication for fixed orthodontic treatment requiring bilateral extraction of the maxillary first premolars. * Similar position, morphology, and dimensions of the maxillary canines on both sides. * No previous orthodontic treatment. * Willingness to participate in the study and provision of informed consent. Exclusion Criteria: * Patients with bleeding or coagulation disorders, diabetes mellitus, bone diseases, or periodontal diseases. * Use of medications that may affect orthodontic tooth movement or coagulation, including aspirin, heparin, warfarin, nonsteroidal anti-inflammatory drugs, or glucocorticoids. * History of maxillofacial trauma or craniofacial anomalies. * Smoking. * Pregnancy. * Requirement for extraction of teeth other than the first premolars.

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As listed by the trial registrant

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Malocclusion class I

How to take part

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Contacts and locations

Locations

  • Saigon Dental Clinic - Dr. Lam

    RECRUITING

    Can Tho, CAN THO, Vietnam

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