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Can magnesium calm patients after surgery as well as a common sedative?

NCT ID NCT07544173

Symptom relief Sponsor: Indonesia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether magnesium sulphate can prevent agitation after ear, nose, and throat surgery as effectively as dexmedetomidine. Sixty-four adults received one of the two drugs during surgery. Researchers measured how many patients became restless or confused as they woke up from anesthesia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
magnesium sulphate and dexmedetomidine
What this could lead to
If magnesium works as well as dexmedetomidine, it could offer a cheaper, safer option to prevent confusion and restlessness after surgery.
What could go wrong
This is a small, completed Phase 4 trial with only 64 participants. Results may not apply to all patients or surgeries, and both drugs can cause side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

64 people

The number who actually took part.

Started

May 2024

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged 18-70 years * ASA physical status I or II * Undergoing elective otorhinolaryngology surgery under general anesthesia * Willing to participate and provide informed consent Exclusion Criteria: * Pregnant patients * Severe cognitive impairment * Known allergy to study drugs * Contraindications to study drugs (atrioventricular block, sinoatrial node dysfunction, renal failure) * Neuromuscular disorders * Regular use of beta-blockers or clonidine * Not extubated in the operating room or post-anesthesia care unit after procedure * Body mass index (BMI) ≥ 40

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Conditions

The condition(s) this trial relates to.

Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adults undergoing otorhinolaryngology surgery

Contacts and locations

Locations

  • Cipto Mangunkusumo Central National Hospital

    Jakarta Pusat, DKI Jakarta, 10430, Indonesia