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Could a common mineral salt boost survival after pesticide poisoning?

NCT ID NCT07777835

Disease control Sponsor: Muhammad Aamir Latif Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This trial tests whether adding magnesium sulfate to the standard antidotes for organophosphate poisoning—a common cause of severe illness from pesticides—can improve outcomes. Adults aged 18 to 50 with confirmed oral pesticide poisoning will receive either standard treatment alone or standard treatment plus a 24-hour magnesium sulfate infusion. Researchers will compare death rates within 15 days and the total atropine needed, as well as the development of a complication called intermediate syndrome.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
magnesium sulfate (MgSO4) given as an intravenous infusion alongside standard atropine and pralidoxime therapy
What this could lead to
If adding magnesium sulfate works, it could reduce deaths and the amount of atropine needed in people with severe pesticide poisoning.
What could go wrong
This is a small early-stage trial, so results may not apply broadly. Magnesium sulfate can cause side effects like low blood pressure or breathing problems, especially in people with kidney issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 38 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Both genders * Adult patients aged between 18 and 50 years * Confirmed clinical diagnosis of organophosphate poisoning containing insecticide, through the oral route * Adult patients, or their legally authorized representative, who will provide informed consent to participate in the study Exclusion Criteria: * Patients with known allergy to MgSO4 * Patients with documented pre-existing renal impairment (Serum creatinine more than 1.5mg/dl) * Patients with documented pre-existing cardiac impairments (e.g., heart block) * Pregnant or lactating women * Confirmed intake of any other drug or poison * Patients who will be declared dead on arrival or those who expired within 2 hours of presentation

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Conditions

The condition(s) this trial relates to.

organophosphate poisoning

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Organophosphate poisoning

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Nishtar Hospital/Medical University

    RECRUITING

    Multan, Punjab Province, 60000, Pakistan