New hope for lymphoma: first human trial of SGN-35C begins
NCT ID NCT06254495
First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 26 times
Summary
This early-stage trial tests a new drug, PF-08046044/SGN-35C, in 57 adults with advanced lymphomas (Hodgkin, T-cell, or B-cell types) who have run out of standard options. The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Because this is a first-in-human study, the focus is on side effects and dosing, not a cure.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Centro Ricerche Cliniche di Verona s.r.l.
Verona, 37134, Italy
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City of Hope (City of Hope National Medical Center, City Of Hope Medical Center)
Duarte, California, 91010, United States
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Fred Hutchinson Cancer Research Center | Seattle, WA
Seattle, Washington, 98109, United States
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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IP Address: City of Hope Investigational Drug Services(IDS)
Duarte, California, 91010, United States
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Institut Gustave Roussy
Villejuif, 94805, France
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Nebraska Medical Center
Omaha, Nebraska, 68105, United States
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Nebraska Medicine - Bellevue Medical Center
Bellevue, Nebraska, 68123, United States
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Nebraska Medicine - Village Pointe
Omaha, Nebraska, 68118, United States
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Rigshospitalet University Hospital of Copenhagen
Copenhagen Ø, DK 2100, Denmark
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Robert Wood Johnson University Hospital
New Brunswick, New Jersey, 08901, United States
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Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08901, United States
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Sylvester Comprehensive Cancer Center - Hollywood
Hollywood, Florida, 33021, United States
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Sylvester Comprehensive Cancer Center - Kendall
Miami, Florida, 33176, United States
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Sylvester Comprehensive Cancer Center- The Lennar Foundation Medical Center
Coral Gables, Florida, 33146, United States
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The Christie NHS Foundation Trust
Manchester, M20 4BX, United Kingdom
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The Royal Marsden NHS Foundation Trust (RM)
Sutton, Surrey, SM2 5PT, United Kingdom
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The University of Kansas Cancer Center - Indian Creek Campus
Overland Park, Kansas, 66211, United States
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The University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri, 64064, United States
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The University of Kansas Cancer Center - Overland Park
Overland Park, Kansas, 66210, United States
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The University of Kansas Cancer Center, Investigational Drug Services
Fairway, Kansas, 66205, United States
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The University of Kansas Hospital
Kansas City, Kansas, 66160, United States
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The University of Kansas Hospital Cambridge North Tower A
Kansas City, Kansas, 66160, United States
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The University of Kansas Medical Center Medical Office Building
Kansas City, Kansas, 66160, United States
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University Of Miami Hospital and Clinics/Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States
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University Of Miami Hospitals And Clinics
Miami, Florida, 33136, United States
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University of California, San Francisco Medical Center
San Francisco, California, 94143, United States
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University of Kansas Cancer Center
Westwood, Kansas, 66205, United States
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University of Kansas Clinical Research Center
Fairway, Kansas, 66205, United States
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University of Miami Hospital and Clinics - Deerfield Beach
Deerfield Beach, Florida, 33442, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
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University of Washington
Seattle, Washington, 98195, United States
Conditions
Explore the condition pages connected to this study.