Radioactive drug shows promise in slowing advanced gut tumors

NCT ID NCT05459844

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 28 times

Summary

This phase 3 study tested a radioactive drug called Lutetium-177 oxodotreotide against a high-dose standard drug (Octreotide LAR) in 196 adults with advanced neuroendocrine tumors that could not be removed by surgery. The goal was to see which treatment better delayed tumor growth. Participants received either the radioactive injection or the standard hormone therapy, and the study measured how long they lived without their cancer getting worse.

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Contacts and locations

Locations

  • Affiliated Hospital of Southwest Medical University

    Luzhou, Sichuan, 646000, China

  • Chinese PLA General Hospital

    Beijing, Beijing Municipality, 100853, China

  • Fudan University Shanghai Cancer Center

    Shanghai, Shanghai Municipality, 200032, China

  • Henan Provincial People's Hospital

    Zhengzhou, Henan, 450003, China

  • Mianyang Central Hospital

    Mianyang, Sichuan, 621099, China

  • Nanjing First Hospital

    Nanjing, Jiangsu, 210006, China

  • Qilu Hospital of Shandong University

    Jinan, Shandong, 250012, China

  • The First Affiliated Hospital of AFMU

    Xi'an, Shaanxi, 710032, China

  • The First Affiliated Hospital of Jinan University

    Guangzhou, Guangdong, 510630, China

  • The First Affiliated Hospital of Shanxi Medical University

    Taiyuan, Shanxi, 030012, China

  • The First Affiliated Hospital of Sun Yat-sen University

    Guangzhou, Guangdong, 510080, China

  • The First Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, Shaanxi, 710061, China

  • The First Affiliated Hospital of Xiamen University

    Xiamen, Fujian, 361003, China

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, 450052, China

  • The First Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310003, China

  • The First Afilliated Hospital of Fujian Medical University

    Fuzhou, Fujian, 350005, China

  • The first hospital of Jilin University

    Changchun, Jilin, 130021, China

  • Tianjin Medical University Cancer Institute & Hospital

    Tianjin, Tianjin Municipality, 300060, China

  • Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology

    Wuhan, Hubei, 430030, China

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei, 430022, China

  • West China Hospital of Sichuan University

    Chengdu, Sichuan, 610041, China

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang, 310022, China

  • Zhongshan Hospital, Fudan University

    Shanghai, Shanghai Municipality, 200032, China

Conditions

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