New combo aims to cut transfusions for blood disorder patients

NCT ID NCT07338344

Recruiting now Disease control Sponsor: Rongrong Liu Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests whether adding low-dose thalidomide to luspatercept can reduce the number of blood transfusions needed by adults with transfusion-dependent β-thalassemia. 78 participants will be randomly assigned to receive either the combination or luspatercept alone for 48 weeks. The main goal is to see if the combo leads to a 50% or greater reduction in transfusion needs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: luspatercept combined with low-dose thalidomide
What this could lead to: If it works, this combination could reduce the need for regular blood transfusions in people with β-thalassemia, improving their quality of life.
What could go wrong: This is a small Phase 2 trial, so results may not apply to everyone. The combination may cause side effects or not work better than luspatercept alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

beta-thalassemia major

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRANSFUSION-DEPENDENT Β-THALASSEMIA PATIENTS

Contacts and locations

Locations

Affiliated Hospital of Youjiang Medical College for Nationalities
RECRUITING

Baise City, Guangxi, 533000, China
Baise People's Hospital
RECRUITING

Baise City, Guangxi, 533000, China
Liuzhou People's Hospital
RECRUITING

Liuzhou, Guangxi, 545007, China
Liuzhou Workers' Hospital
RECRUITING

Liuzhou, Guangxi, 545007, China
Southern Medical University Shenzhen Hospital
RECRUITING

Shenzhen, Guangdong, 518100, China
The First Affiliated Hospital of Guangxi Medical University
RECRUITING

Naning, 530000, China
Yulin First People's Hospital
RECRUITING

Yulin, Guangxi, 537000, China
Yunnan Provincial First People's Hospital
RECRUITING

Kunming, Yunnan, 650100, China