Inhaled therapy tested to fight lung transplant rejection
NCT ID NCT03656926
Summary
This study tested whether adding an inhaled form of the drug cyclosporine (L-CsA) to standard care could better preserve lung function in adults who had received a double lung transplant and developed chronic rejection (CLAD-BOS). 169 participants were randomly assigned to receive either the inhaled medication plus standard care or standard care alone for 48 weeks. The main goal was to see if the added treatment could slow the decline in how much air a person can forcefully exhale in one second (FEV1).
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Contacts and locations
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Locations
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Banner Health
Phoenix, Arizona, 85013, United States
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Baylor University Medical Center
Dallas, Texas, 75246, United States
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CHU Erasme
Brussels, Belgium
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CHU Hopital Nord
Marseille, France
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Columbia University Medical Center
New York, New York, 10032, United States
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Complexo Hospitalario de A Coruna
A Coruña, Spain
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Copenhagen University Hospital
Copenhagen, Denmark
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Duke University Medical Center
Durham, North Carolina, 27110, United States
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Hannover Medical School
Hanover, Germany
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Hospital Marques de Valdecilla
Santander, Spain
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Hospital Puerta de Hierro
Madrid, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario Reina Sofía
Córdoba, 14004, Spain
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Hôpitaux Universitaires de Strasbourg
Strasbourg, France
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Indiana University
Indianapolis, Indiana, 46202, United States
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Johns Hopkins University Hospital
Baltimore, Maryland, 21287, United States
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LMU Klinikum Großhadern
Munich, Germany
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Marie-Lannelongue
Le Plessis-Robinson, 92350, France
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Mayo Clinic Jacksonville
Jacksonville, Florida, 32224, United States
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Medical University of Vienna
Vienna, Austria
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Ohio State University Medical Center
Columbus, Ohio, 43210, United States
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Rabin Medical Center
Petah Tikva, Israel
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Royal Papworth Hospital
Cambridge, United Kingdom
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Stanford University Hospital
Palo Alto, California, 94305, United States
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Temple University Hospital
Philadelphia, Pennsylvania, 19140, United States
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UC San Francisco
San Francisco, California, 94143, United States
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UCLA Medical Center
Los Angeles, California, 90095, United States
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Universitair Ziekenhuis Leuven
Leuven, 3000, Belgium
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University Hospital LA Fe
Valencia, Spain
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University of Florida Medical Center
Gainesville, Florida, 32608, United States
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University of Kentucky Albert B. Chandler Hospital
Lexington, Kentucky, 40508, United States
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University of Manchester
Manchester, United Kingdom
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University of Maryland
Baltimore, Maryland, 21201, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15232, United States
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University of South Florida
Tampa, Florida, 33606, United States
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Washington University
St Louis, Missouri, 63110, United States
Conditions
Explore the condition pages connected to this study.