Major lung cancer trial halted early after failing to show clear benefit

NCT ID NCT03924869

Summary

This study tested whether adding an immunotherapy drug (pembrolizumab) to a precise form of radiation (SBRT) was better at controlling early-stage lung cancer than radiation alone. It involved 448 adults with early-stage lung cancer who could not have or chose not to have surgery. The trial was stopped early because an initial analysis did not show the combination was better at preventing the cancer from returning or spreading.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.C. Camargo Cancer Center ( Site 0312)

    São Paulo, 01509-900, Brazil

  • A.O. Universitaria Careggi ( Site 1301)

    Florence, 50134, Italy

  • A.P.H. Paris. Hopital Bichat Claude Bernard ( Site 1114)

    Paris, 75877, France

  • Aichi Cancer Center Hospital ( Site 2804)

    Nagoya, Aichi-ken, 464-8681, Japan

  • Alaska Oncology and Hematology ( Site 3063)

    Anchorage, Alaska, 99508, United States

  • Allegheny General Hospital ( Site 3028)

    Pittsburgh, Pennsylvania, 15212, United States

  • Amethyst Radiotherapy Center-Oncologie Medicala ( Site 3201)

    Florești, Cluj, 407280, Romania

  • Auckland City Hospital ( Site 2900)

    Grafton, Auckland, 1023, New Zealand

  • Austin Health ( Site 2501)

    Melbourne, Victoria, 3084, Australia

  • Azienda Ospedaliera S. Giovanni Addolorata-Oncologia Medica ( Site 1309)

    Roma, 00185, Italy

  • Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 2311)

    Kecskemét, Bács-Kiskun county, 6000, Hungary

  • Banner MD Anderson Cancer Center ( Site 3029)

    Gilbert, Arizona, 85234, United States

  • Baskent Adana Dr Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 2105)

    Adana, 01250, Turkey (Türkiye)

  • CARTI Cancer Center ( Site 3045)

    Little Rock, Arkansas, 72205, United States

  • CEMIC ( Site 0201)

    Buenos Aires, C1431, Argentina

  • CHU Poitiers ( Site 1109)

    Poitiers, Ain, 86021, France

  • CHU de Brest -Site Hopital Morvan ( Site 1100)

    Brest, Finistere, 29200, France

  • CHU de Rouen ( Site 1113)

    Rouen, Seine-Maritime, 76000, France

  • CHUS - Hopital Fleurimont ( Site 0111)

    Sherbrooke, Quebec, J1H 5N4, Canada

  • CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0110)

    Montreal, Quebec, H1T 2M4, Canada

  • CRU Hungary KFT ( Site 2309)

    Miskolc, Borsod-Abauj Zemplen county, 3529, Hungary

  • Cancer Care Northwest ( Site 0063)

    Spokane Valley, Washington, 99216, United States

  • Centrum Onkologii im. prof. Franciszka ukaszczyka-Ambulatorium Chemioterapii ( Site 2407)

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland

  • Charite Universitaetsmedizin Berlin ( Site 1207)

    Berlin, 13353, Germany

  • Chelyabinsk Regional Clinical Oncology Dispensary ( Site 2014)

    Chelyabinsk, Chelyabinsk Oblast, 454087, Russia

  • Chiba University Hospital ( Site 2806)

    Chiba, 260-8677, Japan

  • Chungbuk National University Hospital ( Site 2605)

    Cheongju-si, North Chungcheong, 28644, South Korea

  • Clatterbridge Cancer Center NHS FT ( Site 1800)

    Liverpool, England, L7 8YA, United Kingdom

  • Clínica de Oncologia Reichow ( Site 0319)

    Blumenau, Santa Catarina, 89010-340, Brazil

  • Cox Medical Center North-Cox Medical Center/Hulston Cancer Center/ Radiation Oncology ( Site 3060)

    Springfield, Missouri, 65807, United States

  • Darlington Memorial Hospital NHS Trust ( Site 1810)

    Darlington, DLX 6HX, United Kingdom

  • Debreceni Egyetem Klinikai Kozpont ( Site 2301)

    Debrecen, Hajdú-Bihar, 4032, Hungary

  • Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital ( Site 2101)

    Ankara, 06200, Turkey (Türkiye)

  • Erciyes University Medical Faculty ( Site 2109)

    Kayseri, 38030, Turkey (Türkiye)

  • Evangelisches Krankenhaus Hamm gGmbH ( Site 1205)

    Hamm, North Rhine-Westphalia, 59063, Germany

  • Farkasgyepui Tudogyogyintezet ( Site 2313)

    Farkasgyepű, Veszprém megye, 8582, Hungary

  • Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz ( Site 2312)

    Székesfehérvár, Fejér, 8000, Hungary

  • Fox Chase Cancer Center ( Site 0051)

    Philadelphia, Pennsylvania, 19111, United States

  • Franciscan Health Indianapolis ( Site 0024)

    Indianapolis, Indiana, 46237, United States

  • GUZ Lipetsk Regional Oncology Dispensary ( Site 2010)

    Lipetsk, Lipetsk Oblast, 398005, Russia

  • GenesisCare North Shore ( Site 2508)

    St Leonards, New South Wales, 2065, Australia

  • Goshen Center for Cancer Care ( Site 0022)

    Goshen, Indiana, 46526, United States

  • Guy s and St Thomas Hospital NHS Foundation Trust ( Site 1808)

    London, London, City of, SE1 9RT, United Kingdom

  • Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2116)

    Istanbul, 34722, Turkey (Türkiye)

  • H. Lee Moffitt Cancer Center and Research Institute ( Site 0016)

    Tampa, Florida, 33612, United States

  • Hacettepe University Medical Faculty ( Site 2100)

    Ankara, 06100, Turkey (Türkiye)

  • Health Sciences North Research Institute ( Site 0107)

    Greater Sudbury, Ontario, P3E 5J1, Canada

  • Helse Bergen HF Haukeland Universitetssykehus ( Site 1502)

    Bergen, Vestfold, 5021, Norway

  • Hematology-Oncology Associates of CNY ( Site 3055)

    East Syracuse, New York, 13057, United States

  • Hiroshima University Hospital ( Site 2810)

    Hiroshima, 734-8551, Japan

  • Hopital Cochin ( Site 1107)

    Paris, 75014, France

  • Hopital Sud du Amiens ( Site 1115)

    Amiens, Somme, 80054, France

  • Hopitaux Universitaires de Geneve HUG ( Site 1706)

    Geneva, Canton of Geneva, 1211, Switzerland

  • Hospital Aleman ( Site 0200)

    Buenos Aires, C1118AAT, Argentina

  • Hospital Britanico de Buenos Aires ( Site 0204)

    Buenos Aires, Buenos Aires F.D., C1280AEB, Argentina

  • Hospital General Universitari Vall d Hebron ( Site 1602)

    Barcelona, 08035, Spain

  • Hospital General Universitario Gregorio Maranon ( Site 1604)

    Madrid, 28009, Spain

  • Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0206)

    ABB, Buenos Aires F.D., C1199ABB, Argentina

  • Hospital Paulistano - Amil Clinical Research ( Site 0316)

    São Paulo, 01321-001, Brazil

  • Hospital Provincial del Centenario ( Site 0205)

    Rosario, Santa Fe Province, S2002KDS, Argentina

  • Hospital Universitario La Fe ( Site 1603)

    Valencia, Valenciana, Comunitat, 46206, Spain

  • Hospital Universitario Quiron Madrid ( Site 1601)

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • Hospital e Maternidade Celso Pierro ( Site 0313)

    Campinas, São Paulo, 13060-904, Brazil

  • I.E.U. Medical Point Hastanesi ( Site 2115)

    Izmir, 35520, Turkey (Türkiye)

  • IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 0208)

    Buenos Aires, 1012, Argentina

  • Icon Cancer Centre Hobart ( Site 2507)

    Hobart, Tasmania, 7000, Australia

  • Infirmary Cancer Care ( Site 3044)

    Mobile, Alabama, 36607, United States

  • Institut Bergonie ( Site 1102)

    Bordeaux, Gironde, 33076, France

  • Institut Curie ( Site 1112)

    Paris, 75005, France

  • Institut Regional du Cancer de Montpellier - ICM ( Site 1108)

    Montpellier, Herault, 34298, France

  • Instituto Medico Especializado Alexander Fleming ( Site 0203)

    Buenos Aires, C1426ANZ, Argentina

  • Instituto Nacional Do Cancer Jose Alencar Gomes Da Silva ( Site 0305)

    Rio de Janeiro, 20231-050, Brazil

  • Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0300)

    São Paulo, 01246-000, Brazil

  • Institutul Oncologic-Oncologie Medicala ( Site 3202)

    Cluj-Napoca, 400015, Romania

  • Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 0318)

    Porto Alegre, Rio Grande do Sul, 90050-170, Brazil

  • John Theurer Cancer Center at Hackensack University Medical Center ( Site 3036)

    Hackensack, New Jersey, 07601, United States

  • Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 2310)

    Szolnok, Jász-Nagykun-Szolnok, 5004, Hungary

  • Kansai Medical University Hospital ( Site 2808)

    Hirakata, Osaka, 573-1191, Japan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 3304)

    Kaohsiung City, 807, Taiwan

  • Kartal Training and Research Hospital ( Site 2102)

    Istanbul, 34890, Turkey (Türkiye)

  • Keppler Universitatsklinikum ( Site 0806)

    Linz, Upper Austria, 4021, Austria

  • Kingston Health Sciences Centre ( Site 0100)

    Kingston, Ontario, K7L 2V7, Canada

  • Klinikum Esslingen-Klinik für Kardiologie und Pneumologie ( Site 1208)

    Esslingen am Neckar, Baden-Wurttemberg, 73730, Germany

  • Kobe Minimally Invasive Cancer Center ( Site 2811)

    Kobe, Hyōgo, 650-0046, Japan

  • Kurume University Hospital ( Site 2815)

    Kurume, Fukuoka, 830-0011, Japan

  • Kyiv City Clinical Oncology Centre ( Site 2200)

    Kyiv, 03115, Ukraine

  • Lancashire Teaching Hospitals NHS Foundation Trust ( Site 1809)

    Preston, Lancashire, PR2 9HT, United Kingdom

  • Landeskrankenhaus - Universitatsklinikum Graz ( Site 0804)

    Graz, Styria, 8036, Austria

  • Lankenau Medical Center ( Site 3041)

    Wynnewood, Pennsylvania, 19096, United States

  • Lehigh Valley Hospital- Cedar Crest ( Site 3005)

    Allentown, Pennsylvania, 18103, United States

  • Leicester Royal Infirmary ( Site 1811)

    Leicester, Leicestershire, LE1 5WW, United Kingdom

  • Mass General / North Shore Center for Outpatient Care ( Site 3040)

    Danvers, Massachusetts, 01923, United States

  • Massachusetts General Hospital-Cancer Center Protocol Office ( Site 3007)

    Boston, Massachusetts, 02114, United States

  • McGill University Health Centre ( Site 0113)

    Montreal, Quebec, H4A 3J1, Canada

  • Meander Medisch Centrum-Studie Team Oncologie ( Site 1403)

    Amersfoort, Utrecht, 3813 TZ, Netherlands

  • Medical Center Asklepion LLC ( Site 2208)

    Khodosovka, Kyivska Oblast, 08173, Ukraine

  • Medical Center of Yuriy Spizhenko LLC.-Clinical Trial ( Site 2205)

    Kapitanivka Village, Kyivska Oblast, 08111, Ukraine

  • Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 2203)

    Kyiv, Kyivska Oblast, 03126, Ukraine

  • Medical center Medikal Plaza of Ecodnipro LLC ( Site 2207)

    Dnipro, Dnipropetrovsk Oblast, 49055, Ukraine

  • Medical institute named after Berezin Sergey ( Site 2009)

    Saint Petersburg, Sankt-Peterburg, 197758, Russia

  • Mid Florida Hematology and Oncology Center ( Site 0067)

    Orange City, Florida, 32763, United States

  • Moncton Hospital - Horizon Health Network ( Site 0105)

    Moncton, New Brunswick, E1C 6Z8, Canada

  • Mount Sinai Hospital ( Site 0046)

    New York, New York, 10029, United States

  • Mount Vernon Hospital ( Site 1803)

    Northwood, HA6 2RN, United Kingdom

  • Mountain States Health Alliance ( Site 3054)

    Johnson City, Tennessee, 37604, United States

  • N.N.Blokhin Russian Cancer Research center ( Site 2013)

    Moscow, Moscow, 115478, Russia

  • Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2403)

    Gliwice, Silesian Voivodeship, 44-101, Poland

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • National Cancer Center ( Site 2604)

    Goyang-si, Kyonggi-do, 10408, South Korea

  • National Cancer Center Hospital East ( Site 2800)

    Kashiwa, Chiba, 2778577, Japan

  • National Hospital Organization Kyushu Cancer Center ( Site 2816)

    Fukuoka, 811-1395, Japan

  • National Jewish Health ( Site 0010)

    Denver, Colorado, 80206, United States

  • Niigata Cancer Center Hospital ( Site 2801)

    Niigata, 951-8566, Japan

  • Norfolk and Norwich University Foundation NHS Trust ( Site 1805)

    Norwich, Norfolk, NR47UY, United Kingdom

  • Orszagos Koranyi Pulmonologiai Intezet ( Site 2304)

    Budapest, 1121, Hungary

  • Orszagos Koranyi Pulmonologiai Intezet ( Site 2306)

    Budapest, 1121, Hungary

  • Orszagos Onkologiai Intezet ( Site 2308)

    Budapest, 1122, Hungary

  • Osaka International Cancer Institute ( Site 2812)

    Osaka, 541-8567, Japan

  • Osaka Medical and Pharmaceutical University Hospital ( Site 2813)

    Takatsuki, Osaka, 5698686, Japan

  • Oslo Universitetssykehus HF Ulleval Sykehus ( Site 1500)

    Oslo, 0450, Norway

  • Ospedale Santissima Annunziata ( Site 1303)

    Chieti, 66100, Italy

  • Oxford University Hospitals NHS Foundation Trust ( Site 1812)

    Oxford, Oxfordshire, OX3 7LE, United Kingdom

  • Penn State University Milton S. Hershey Medical Center ( Site 0064)

    Hershey, Pennsylvania, 17033, United States

  • Petz Aladar Megyei Oktato Korhaz ( Site 2305)

    Győr, Győr-Moson-Sopron, 9024, Hungary

  • Pius Hospital Oldenburg ( Site 1202)

    Oldenburg, Lower Saxony, 26121, Germany

  • Policlinico Agostino Gemelli ( Site 1302)

    Roma, 00168, Italy

  • Policlinico di Modena ( Site 1306)

    Modena, 41124, Italy

  • Port Macquarie Base Hospital ( Site 2500)

    Port Macquarie, New South Wales, 2444, Australia

  • Pécsi Tudományegyetem Klinikai Központ-Onkoterápiás Intézet ( Site 2314)

    Pécs, Baranya, 7624, Hungary

  • Regional Centre of Oncology-Thoracic organs ( Site 2202)

    Kharkiv, Kharkivs’ka Oblast’, 61070, Ukraine

  • Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 2001)

    Kazan', Tatarstan, Respublika, 420029, Russia

  • Royal Brisbane and Women s Hospital ( Site 2502)

    Herston, Queensland, 4029, Australia

  • Royal Free London NHS Foundation Trust ( Site 1813)

    London, Camden, NW3 2QG, United Kingdom

  • Russian Scientific Center of Roentgenoradiology ( Site 2011)

    Moscow, Moscow, 117997, Russia

  • Rutgers Cancer Institute of New Jersey ( Site 0043)

    New Brunswick, New Jersey, 08903-2681, United States

  • SPZOZ MSWIA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie ( Site 2404)

    Olsztyn, Warmian-Masurian Voivodeship, 10-228, Poland

  • Sakarya Universitesi Tip Fakultesi Hastanesi ( Site 2114)

    Sakarya, 54290, Turkey (Türkiye)

  • Samsung Medical Center ( Site 2603)

    Seoul, 06351, South Korea

  • Sanatorio Parque ( Site 0207)

    Rosario, Santa Fe Province, S2000DSV, Argentina

  • Sanford Bemidji ( Site 0080)

    Bemidji, Minnesota, 56601, United States

  • Sanford Cancer Center Oncology Clinic ( Site 0053)

    Sioux Falls, South Dakota, 57104, United States

  • Sanford Health Roger Maris Cancer Center ( Site 0079)

    Fargo, North Dakota, 58102, United States

  • Sault Area Hospital ( Site 0101)

    Sault Ste. Marie, Ontario, P6B 0A8, Canada

  • Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 2000)

    Saint Petersburg, Sankt-Peterburg, 197758, Russia

  • Semmelweis University ( Site 2303)

    Budapest, 1085, Hungary

  • Sendai Kousei Hospital ( Site 2814)

    Sendai, Miyagi, 980-0873, Japan

  • Seoul National University Hospital ( Site 2600)

    Seoul, 03080, South Korea

  • Showa University Hospital ( Site 2805)

    Tokyo, 142-8666, Japan

  • Sinai Hospital of Baltimore ( Site 3011)

    Baltimore, Maryland, 21215, United States

  • Social Medical Center - Otto Wagner Hospital ( Site 0801)

    Vienna, Vienna, 1145, Austria

  • Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 2307)

    Kaposvár, Somogy County, 7400, Hungary

  • St Olavs Hospital ( Site 1504)

    Trondheim, Sor-Trondelag, 7030, Norway

  • St. Luke's University Health Network ( Site 3006)

    Bethlehem, Pennsylvania, 18015, United States

  • St. Vincent Healthcare Frontier Cancer Center ( Site 3012)

    Billings, Montana, 59102, United States

  • Sverdlovsk Regional Oncology Hospital ( Site 2012)

    Yekaterinburg, Sverdlovsk Oblast, 620036, Russia

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 2400)

    Krakow, Lesser Poland Voivodeship, 31-826, Poland

  • Taipei Medical University Hospital ( Site 3303)

    Taipei, 110301, Taiwan

  • Taipei Veterans General Hospital ( Site 3301)

    Taipei, 11217, Taiwan

  • Tergooiziekenhuizen, locatie Hilversum-Oncology ( Site 1407)

    Hilversum, North Holland, 1213 XZ, Netherlands

  • The Cancer Institute Hospital of JFCR ( Site 2803)

    Tokyo, 135-8550, Japan

  • The Catholic University of Korea St. Vincent s Hospital ( Site 2606)

    Gyeonggi-do, Kyonggi-do, 16247, South Korea

  • The Ottawa Hospital ( Site 0104)

    Ottawa, Ontario, K1H 8L6, Canada

  • Tokyo Metropolitan Komagome Hospital ( Site 2802)

    Tokyo, 113-8677, Japan

  • Tri-Service General Hospital ( Site 3300)

    Taipei City, Taipei, 114, Taiwan

  • Trillium Health Partners - Credit Valley Hospital ( Site 0102)

    Mississauga, Ontario, L5M 2N1, Canada

  • Törökbálinti Tüdőgyógyintézet ( Site 2302)

    Törökbálint, Pest County, 2045, Hungary

  • UKGM Gießen/Marburg-Medical Clinic V ( Site 1210)

    Giessen, Hesse, 35392, Germany

  • USC Norris Comprehensive Cancer Center ( Site 0007)

    Los Angeles, California, 90033, United States

  • Ukrainian Center of Tomotherapy ( Site 2206)

    Kropyvnitskiy, Kirovohrad Oblast, 25011, Ukraine

  • Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 0301)

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Universitaetsklinikum Erlangen ( Site 1209)

    Erlangen, Bavaria, 91054, Germany

  • Universitaetsklinikum Essen ( Site 1201)

    Essen, North Rhine-Westphalia, 45147, Germany

  • Universitaetsklinikum Heidelberg. ( Site 1204)

    Heidelberg, Baden-Wurttemberg, 69126, Germany

  • Universitaetsspital Zuerich ( Site 1700)

    Zurich, Canton of Zurich, 8091, Switzerland

  • Universitatsklinik LKH Innsbruck ( Site 0802)

    Innsbruck, Tyrol, 6020, Austria

  • University College London Hospital NHS Foundation Trust ( Site 1806)

    London, London, City of, NW1 2BU, United Kingdom

  • University Hospitals Bristol NHS Foundation Trust ( Site 1802)

    Bristol, Bristol, City of, BS2 8ED, United Kingdom

  • University of Alabama ( Site 0099)

    Birmingham, Alabama, 35233, United States

  • University of Kentucky School of Medicine & Hospitals ( Site 0026)

    Lexington, Kentucky, 40536, United States

  • University of Massachusetts ( Site 0029)

    Worcester, Massachusetts, 01655, United States

  • University of Minnesota ( Site 0069)

    Minneapolis, Minnesota, 55455, United States

  • University of Missouri Hospital ( Site 3058)

    Columbia, Missouri, 65212, United States

  • University of Tennessee Medical Center Knoxville ( Site 3010)

    Knoxville, Tennessee, 37920, United States

  • University of Tsukuba Hospital ( Site 2809)

    Tsukuba, Ibaraki, 305-8576, Japan

  • University of Yamanashi Hospital ( Site 2807)

    Chūō, Yamanashi, 409-3898, Japan

  • Vanderbilt University Medical Center ( Site 0075)

    Nashville, Tennessee, 37232, United States

  • Veterans Affairs Palo Alto Health Care System ( Site 3039)

    Palo Alto, California, 94304, United States

  • Westchester Medical Center ( Site 3057)

    Valhalla, New York, 10595, United States

  • Weston Park Hospital ( Site 1801)

    Sheffield, Derbyshire, S10 2SJ, United Kingdom

  • White Plains Hospital ( Site 3014)

    White Plains, New York, 10601, United States

  • William E. Kahlert Regional Cancer Center ( Site 3031)

    Westminster, Maryland, 21157, United States

  • Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii ( Site 2402)

    Lodz, Łódź Voivodeship, 93-513, Poland

  • Yale University ( Site 0011)

    New Haven, Connecticut, 06510, United States

  • Ziekenhuis Rijnstate ( Site 1405)

    Arnhem, Gelderland, 6815 AD, Netherlands

Conditions

Explore the condition pages connected to this study.