New hope for tough lung cancers: drug combo trial targets resistant tumors

NCT ID NCT05781308

First seen Nov 18, 2025 · Last updated May 13, 2026 · Updated 14 times

Summary

This study tests whether adding an immunotherapy drug (atezolizumab) to a standard chemotherapy (paclitaxel) and a targeted therapy (bevacizumab) can help people with advanced non-squamous lung cancer whose disease has worsened after prior immunotherapy and chemotherapy. About 156 adults with good performance status will be randomly assigned to receive either the two-drug or three-drug combination. The main goal is to see how many patients are alive without their cancer growing after 6 months.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • APHM Hôpital Nord

    Marseille, France

  • CH Annecy Genevois

    Pringy, France

  • CH Avignon

    Avignon, France

  • CH Cholet

    Cholet, France

  • CH Côte Basque

    Bayonne, France

  • CH Le Mans

    Le Mans, France

  • CH Pasteur

    Colmar, France

  • CH Pau

    Pau, France

  • CH Versailles

    Le Chesnay, France

  • CH Villefranche Nord Ouest

    Villefranche-sur-Saône, 69655, France

  • CHD Vendée

    La Roche-sur-Yon, France

  • CHR Orléans

    Orléans, France

  • CHU Amiens

    Amiens, France

  • CHU Besançon - Hôpital J. MINJOZ

    Besançon, 25030, France

  • CHU Bordeaux Haut-Lévèque

    Pessac, France

  • CHU Côte de Nacre

    Caen, 14000, France

  • CHU Dijon

    Dijon, France

  • CHU Gabriel Montpied

    Clermont-Ferrand, France

  • CHU Lille

    Lille, France

  • CHU Limoges

    Limoges, 87042, France

  • CHU Poitiers

    Poitiers, France

  • CHU Rouen

    Rouen, 76031, France

  • CHU Saint Etienne

    Saint-Etienne, France

  • CHU Toulouse

    Toulouse, 31059, France

  • CHU Tours

    Tours, France

  • CHU d'Angers

    Angers, 49033, France

  • Centre Georges-François Leclerc

    Dijon, 21079, France

  • Centre Hospitalier Intercommunal Créteil CHIC

    Créteil, France

  • Centre Léon Bérard

    Lyon, 69373, France

  • Chu Grenoble

    Grenoble, 38043, France

  • Clinique Teissier

    Valenciennes, France

  • GHR Mulhouse et Sud Alsace GHRMSA

    Mulhouse, 68070, France

  • Groupe Hospitalier Paris Saint Joseph GHPSJ

    Paris, France

  • HIA Sainte-Anne

    Toulon, 83800, France

  • Hospices Civils de Lyon - URCOT

    Pierre-Bénite, France

  • Hôpital APHP Ambroise Paré

    Boulogne, 92104, France

  • Hôpital BICHAT

    Paris, 75877, France

  • Hôpital Européen

    Marseille, France

  • Hôpital TENON

    Paris, 75970, France

  • Hôpitaux Privés de Metz Robert Schuman

    Metz, France

  • Institut Paoli Calmettes

    Marseille, 13273, France

  • Institut de Cancerologie de l'Ouest ICO

    Saint-Herblain, France

  • Nouvel Hôpital Civil - Hôpitaux Universitaires de Strasbourg

    Strasbourg, 67091, France

  • Polyclinique Bordeaux Nord Aquitaine

    Bordeaux, France

Conditions

Explore the condition pages connected to this study.