New hope before surgery: boosting immune system to fight lung cancer

NCT ID NCT02998528

Completed Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding immunotherapy drugs (nivolumab with or without ipilimumab) to standard chemotherapy before lung cancer surgery is better than chemotherapy alone. It involved 505 people with early-stage, operable non-small cell lung cancer. The goal was to see if the combination treatments were safer and more effective at shrinking tumors and preventing cancer from returning.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Christ Hospital

Cincinnati, Ohio, 45219, United States
Fundacao Pio Xii Hosp Cancer De Barretos

Barretos, São Paulo, 14784-400, Brazil
Illinois Cancer Specialists

Niles, Illinois, 60714, United States
Indian River Medical Center

Vero Beach, Florida, 32960, United States
Intermountain Medical Center

Murray, Utah, 84107, United States
Kaiser Permanente

Portland, Oregon, 97227, United States
Local Institution

Beijing, Beijing Municipality, 100730, China
Local Institution

Changchun, Jilin, 130012, China
Local Institution

Budapest, 1125, Hungary
Local Institution

Székesfehérvár, 8000, Hungary
Local Institution - 0001

Baltimore, Maryland, 21287, United States
Local Institution - 0002

Chicago, Illinois, 60637, United States
Local Institution - 0003

Salt Lake City, Utah, 84112, United States
Local Institution - 0005

Nashville, Tennessee, 37232, United States
Local Institution - 0006

Newton, Massachusetts, 02459, United States
Local Institution - 0007

Plainville, Connecticut, 06062, United States
Local Institution - 0008

Boston, Massachusetts, 02215, United States
Local Institution - 0009

Hackensack, New Jersey, 07601, United States
Local Institution - 0010

Philadelphia, Pennsylvania, 19111, United States
Local Institution - 0011

New York, New York, 10016, United States
Local Institution - 0012

Detroit, Michigan, 48202-2608, United States
Local Institution - 0013

Charleston, South Carolina, 29414, United States
Local Institution - 0015

Chicago, Illinois, 60611, United States
Local Institution - 0016

Saskatoon, Saskatchewan, S7N 4H4, Canada
Local Institution - 0017

Montreal, Quebec, H4A 3J1, Canada
Local Institution - 0018

Pittsburgh, Pennsylvania, 15212, United States
Local Institution - 0019

Athens, 11527, Greece
Local Institution - 0021

Charleston, South Carolina, 29425, United States
Local Institution - 0022

Capital Federal, Buenos Aires, 1426, Argentina
Local Institution - 0023

Ciudad Autonoma de Buenos Aire, Buenos Aires, 1181, Argentina
Local Institution - 0025

Denver, Colorado, 80218, United States
Local Institution - 0026

Waco, Texas, 76712, United States
Local Institution - 0027

Albany, New York, 12208, United States
Local Institution - 0028

Barcelona, 08035, Spain
Local Institution - 0029

Madrid, 28041, Spain
Local Institution - 0031

Majadahonda - Madrid, 28222, Spain
Local Institution - 0032

Las Vegas, Nevada, 89128, United States
Local Institution - 0035

Austin, Texas, 78745, United States
Local Institution - 0050

Craiova, 200347, Romania
Local Institution - 0051

Romania, 400015, Romania
Local Institution - 0052

Trois-Rivières, Quebec, G8Z 3R9, Canada
Local Institution - 0054

Orlando, Florida, 32804, United States
Local Institution - 0058

Toulouse, 31059, France
Local Institution - 0059

Marseille, 13915, France
Local Institution - 0060

Paris, 75018, France
Local Institution - 0061

Rennes, 35033, France
Local Institution - 0062

Tours, 37044, France
Local Institution - 0064

Pierre Benite Cedax, 69495, France
Local Institution - 0066

Ravenna, 48121, Italy
Local Institution - 0067

Roma, 00149, Italy
Local Institution - 0068

Bari, 70124, Italy
Local Institution - 0069

Sector 2, 022328, Romania
Local Institution - 0070

Perugia, 06129, Italy
Local Institution - 0073

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Local Institution - 0075

Rio de Janeiro, 22793-080, Brazil
Local Institution - 0076

Ijuí, Rio Grande do Sul, 98700-000, Brazil
Local Institution - 0077

Belo Horizonte, Minas Gerais, 30130-090, Brazil
Local Institution - 0079

Brasília, Federal District, 70200-730, Brazil
Local Institution - 0080

Genova, 16132, Italy
Local Institution - 0081

Los Angeles, California, 90017, United States
Local Institution - 0084

Ankara, 06100, Turkey (Türkiye)
Local Institution - 0090

Hattiesburg, Mississippi, 39401, United States
Local Institution - 0092

Nashville, Tennessee, 37203, United States
Local Institution - 0093

Adana, 01060, Turkey (Türkiye)
Local Institution - 0095

Gatineau, Quebec, J8P 7H2, Canada
Local Institution - 0097

Busan, 49267, South Korea
Local Institution - 0098

Hwasun, 58128, South Korea
Local Institution - 0099

Taipei, 11031, Taiwan
Local Institution - 0100

Taipei, 112, Taiwan
Local Institution - 0102

New Taipei City, 235, Taiwan
Local Institution - 0105

Seoul, 08308, South Korea
Local Institution - 0106

Houston, Texas, 77090, United States
Local Institution - 0107

Taichung, 407219, Taiwan
Local Institution - 0108

Osaka, 589-8511, Japan
Local Institution - 0109

Hiroshima, Hiroshima, 7348551, Japan
Local Institution - 0110

Fukushima, Fukushima, 9601295, Japan
Local Institution - 0111

Kitakyushu-shi, Fukuoka, 8078555, Japan
Local Institution - 0112

Paris, 75248, France
Local Institution - 0113

Strasbourg, 67100, France
Local Institution - 0115

Istanbul, 34098, Turkey (Türkiye)
Local Institution - 0118

Kashiwa-shi, Chiba, 2778577, Japan
Local Institution - 0119

Sakai-shi, Osaka, 5918555, Japan
Local Institution - 0120

Shinjuku-ku, Tokyo, 1600023, Japan
Local Institution - 0121

Glendale, Arizona, 85308, United States
Local Institution - 0122

Thessaloniki, 57001, Greece
Local Institution - 0123

Yokohama, Kanagawa, 2418515, Japan
Local Institution - 0124

Tokyo, 113-8603, Japan
Local Institution - 0125

Fairfax, Virginia, 22031, United States
Local Institution - 0126

Bunkyo-ku, Tokyo, 1138431, Japan
Local Institution - 0127

Osaka, Osaka, 5418567, Japan
Local Institution - 0131

Nagoya, Aichi-ken, 4640021, Japan
Local Institution - 0132

Sunto-gun, Shizuoka, 4118777, Japan
Local Institution - 0133

Kobe, Hyōgo, 6500047, Japan
Local Institution - 0135

Burlington, Vermont, 05405, United States
Local Institution - 0136

Miami, Florida, 33136, United States
Local Institution - 0138

Montreal, Quebec, H2X 0A9, Canada
Local Institution - 0139

Portland, Oregon, 97239, United States
Local Institution - 0140

High Point, North Carolina, 27262, United States
Local Institution - 0143

Tyler, Texas, 75701, United States
Local Institution - 0146

Greenville, South Carolina, 29607, United States
Local Institution - 0147

Sapporo, Hokkaido, 0030804, Japan
Local Institution - 0148

Sendai, Miyagi, 9800873, Japan
Local Institution - 0149

Zanesville, Ohio, 43701, United States
Local Institution - 0151

Baltimore, Maryland, 21237, United States
Local Institution - 0153

Fort Bliss, Texas, 79918, United States
Local Institution - 0156

Beijing, Beijing Municipality, 100853, China
Local Institution - 0159

Xi'an, Shan1xi, 710061, China
Local Institution - 0160

Shanghai, Shanghai Municipality, 200032, China
Local Institution - 0161

Beijing, Beijing Municipality, 100142, China
Local Institution - 0163

Tianjin, Tianjin Municipality, 300060, China
Local Institution - 0165

Shanghai, 200030, China
Local Institution - 0166

Nanchang, Jiangxi, 330200, China
Local Institution - 0170

Lexington, Kentucky, 40536, United States
Local Institution - 0171

Fort Wayne, Indiana, 46804, United States
Local Institution - 0173

Hollywood, Florida, 33021, United States
Local Institution - 0175

Changsha, Hunan, 410013, China
Local Institution - 0178

Chengdu, Sichuan, 610041, China
Local Institution - 0179

Nanchang, Jiangxi, 330006, China
Local Institution - 0180

Xi'an, Shan3xi, 710038, China
Local Institution - 0182

Hangzhou, Zhejiang, 310022, China
Local Institution - 0183

Hangzhou, Zhejiang, 310016, China
Local Institution - 0186

Louisville, Kentucky, 40202, United States
Local Institution - 0189

Hangzhou, Zhejiang, 310003, China
Local Institution - 0190

Guangzhou, Guangdong, 510095, China
Local Institution - 0192

Changsha, Hunan, 410008, China
Local Institution - 0193

Changsha, Hunan, 410013, China
Local Institution - 0198

Fredericksburg, Virginia, 22408, United States
MetroHealth Medical Center

Cleveland, Ohio, 44109, United States
Northwest Georgia Oncology Center, P.C.

Marietta, Georgia, 30060, United States
Orlando Health, Inc.

Orlando, Florida, 32806, United States
Southcoast Center For Cancer

Fairhaven, Massachusetts, 02719, United States
Southwest Cancer Center

Lubbock, Texas, 79415, United States
Southwest Regional Cancer Clinic

St. George, Utah, 84770, United States
St Vincent Frontier Cancer Center

Billings, Montana, 59102, United States
Texas Cancer Center - Sherman

Sherman, Texas, 75090-0504, United States
Texas Oncology

Bedford, Texas, 76022, United States
University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States
Valley Hospital Luckow Pavili

Westwood, New Jersey, 07675, United States

Conditions

Explore the condition pages connected to this study.

NON-SMALL CELL LUNG CANCER