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Experimental combo for lung cancer and mesothelioma shows promise but trial halted

NCT ID NCT04914897

Terminated Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 21 times

Summary

This study tested a new drug called SAR444245 combined with other cancer treatments in 106 adults with advanced non-small cell lung cancer or pleural mesothelioma. The goal was to see if the combination shrank tumors. The trial was terminated early, so final results are limited.

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Contacts and locations

Locations

  • Investigational Site Number : 0320002

    CABA, Buenos Aires, 1430, Argentina

  • Investigational Site Number : 0360002

    Richmond, Victoria, 3121, Australia

  • Investigational Site Number : 1520001

    Santiago, Reg Metropolitana de Santiago, 8420383, Chile

  • Investigational Site Number : 1520002

    Santiago, Reg Metropolitana de Santiago, 7500921, Chile

  • Investigational Site Number : 1520003

    Temuco, 4800827, Chile

  • Investigational Site Number : 1520004

    Santiago, Reg Metropolitana de Santiago, 7500713, Chile

  • Investigational Site Number : 1520005

    Santaigo, Reg Metropolitana de Santiago, 8241470, Chile

  • Investigational Site Number : 1580002

    Tainan, 704, Taiwan

  • Investigational Site Number : 1580003

    Taichung, 404, Taiwan

  • Investigational Site Number : 1580005

    Taipei, Taiwan

  • Investigational Site Number : 2500001

    Saint-Herblain, 44800, France

  • Investigational Site Number : 2500003

    Toulouse, 31059, France

  • Investigational Site Number : 2500005

    Paris, 75018, France

  • Investigational Site Number : 2500006

    Bordeaux, France

  • Investigational Site Number : 3800001

    Rozzano, Milano, 20089, Italy

  • Investigational Site Number : 3800002

    Orbassano, Torino, 10043, Italy

  • Investigational Site Number : 3800004

    Milan, 20133, Italy

  • Investigational Site Number : 3800005

    Aviano (PN), Friuli Venezia Giulia, 33081, Italy

  • Investigational Site Number : 3800006

    Bologna, 40138, Italy

  • Investigational Site Number : 3800008

    Padova, 35128, Italy

  • Investigational Site Number : 3920001

    Sapporo, Hokkaido, 003-0804, Japan

  • Investigational Site Number : 4100001

    Seoul, Seoul-teukbyeolsi, 06351, South Korea

  • Investigational Site Number : 4100002

    Seoul, Seoul-teukbyeolsi, 03080, South Korea

  • Investigational Site Number : 4100003

    Seoul, Seoul-teukbyeolsi, 05505, South Korea

  • Investigational Site Number : 6160001

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • Investigational Site Number : 6160002

    Poznan, Greater Poland Voivodeship, 60-693, Poland

  • Investigational Site Number : 6160003

    Gdansk, Pomeranian Voivodeship, 80-214, Poland

  • Investigational Site Number : 6160004

    Olsztyn, Warmian-Masurian Voivodeship, 10-357, Poland

  • Investigational Site Number : 7240001

    Madrid, 28041, Spain

  • Investigational Site Number : 7240002

    Madrid, 28034, Spain

  • Investigational Site Number : 7240003

    Girona, Girona [Gerona], 17007, Spain

  • Investigational Site Number : 7240004

    Madrid, Madrid, Comunidad de, 28046, Spain

  • Investigational Site Number : 7240006

    Barcelona, Barcelona [Barcelona], 08035, Spain

  • Thomas Jefferson University - North East Site Number : 8401009

    Philadelphia, Pennsylvania, 19114, United States

  • Thomas Jefferson University Hospital Site Number : 8400009

    Philadelphia, Pennsylvania, 19107, United States

Conditions

Explore the condition pages connected to this study.

NON SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER PLEURAL MESOTHELIOMA