New drug combo could extend lives in aggressive lung cancer
NCT ID NCT05091567
Summary
This large Phase 3 trial is testing whether adding the drug lurbinectedin to standard maintenance therapy (atezolizumab) helps people with extensive-stage small-cell lung cancer live longer without their cancer getting worse. The study involves 660 participants whose cancer responded to or remained stable after initial chemotherapy. After that initial treatment, participants are randomly assigned to receive either the two-drug combination or the single drug alone to see which is better at controlling the disease.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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ASL 3 Genovese
Genoa, Liguria, 16125, Italy
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AUSL della Romagna
Ravenna, Emilia-Romagna, 48121, Italy
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AZ St Maarten Campus Leopoldstr
Mechelen, 2800, Belgium
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Ac?badem Altunizade Hastanesi
Istanbul, 34660, Turkey (Türkiye)
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Adana Baskent University Hospital
Adana, 01120, Turkey (Türkiye)
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Ag. Loukas Hospital
Thessaloniki, 55236, Greece
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Ankara City Hospital
Ankara, 06800, Turkey (Türkiye)
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Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde
Morelia, 58260, Mexico
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Asan Medical Center
Seoul, 05505, South Korea
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Asklepios Klinik Gauting
München-Gauting, 82131, Germany
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Azienda Ospedaliero Universitaria Ospedali Riuniti
Torrette Di Ancona, The Marches, 60126, Italy
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Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda)
Milan, Lombardy, 20162, Italy
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Ba?c?lar Medipol Mega Üniversite Hastanesi
Istanbul, 34214, Turkey (Türkiye)
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Blackpool Victoria Hospital
Blackpool, FY3 8NR, United Kingdom
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CHU UCL Mont-Godinne
Mont-godinne, 5530, Belgium
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Cancer & Hematology Centers of Western Michigan
Grand Rapids, Michigan, 49503, United States
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Castle Hill Hospital
Hull, HU16 5JQ, United Kingdom
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Centrum Onkologii Instytut im.Marii Sklodowskiej-Curie
Warsaw, 02-781, Poland
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Chilgok Kyungpook National University Medical Center
Daegu, 702-210, South Korea
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Christie NHS Foundation Trust
GB Manchester, M20 4BX, United Kingdom
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Chungbuk National University Hospital
Cheongju-si, 28644, South Korea
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Clinical Research Alliance
Westbury, New York, 11590, United States
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Complejo Hospitalario Universitario A Coruña (CHUAC)
A Coruña, LA Coruna, 15006, Spain
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Diavalkaniko Hospital
Thessaloniki, 570 01, Greece
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E-DA Hospital
Kaohsiung City, 824, Taiwan
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Errikos Dynan Hospital
Athens, 11526, Greece
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Euromedical General Clinic of Thessaloniki
Thessaloniki, 546 45, Greece
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Evang. Lungenklinik Berlin Klinik für Pneumologie
Berlin, 13125, Germany
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Fachklinik für Lungenerkrankungen
Immenhausen, 34376, Germany
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Goztepe Prof.Dr. Suleyman Yalcin City Hospital
Kadiköy, 34722, Turkey (Türkiye)
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Greco-Hainesworth Centers for Research
Chattanooga, Tennessee, 37403, United States
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Guy's Hospital
London, SE1 9RT, United Kingdom
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Gyeongsang National University Hospital
Gyeongsangnam-do, 52727, South Korea
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Health Pharma Professional Research
Mexico City, Mexico CITY (federal District), 03100, Mexico
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Helios Klinikum Emil von Behring GmbH
Berlin, 14165, Germany
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Hollings Cancer Center
Charleston, South Carolina, 29425, United States
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Hospital Clinico Universitario Virgen de la Victoria
Málaga, 29010, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
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Hospital de la Santa Creu i Sant Pau
Barcelona, 08041, Spain
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Hospital del Mar
Barcelona, 08003, Spain
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Illinois Cancer Care
Peoria, Illinois, 61615, United States
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Institut Jules Bordet
Anderlecht, 1070, Belgium
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Irccs Istituto Europeo di Oncologia (IEO)
Milan, Lombardy, 20141, Italy
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Istanbul Uni Cerrahpasa Medical Faculty Hospital
Istanbul, 34300, Turkey (Türkiye)
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Izmir Medical Point Hospital
Izmir, 35101, Turkey (Türkiye)
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Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rend.Int.
Szolnok, 5000, Hungary
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Jessa Zkh (Campus Virga Jesse)
Hasselt, 3500, Belgium
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KEM/Evang. Kliniken Essen Mitte gGmbH
Essen, 45136, Germany
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Klinikum Chemnitz gGmbH
Chemnitz, 09116, Germany
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Kocaeli University Faculty of Medicine
İzmit, 31380, Turkey (Türkiye)
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Krakowski Szpital Specjalistyczny im sw. Jana Paw?a II
Krakow, 31-202, Poland
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Krankenhaus Martha-Maria Halle-Doelau gGmbH
Halle, 06120, Germany
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Leicester Royal Infirmary
Leicester, LE1 5WW, United Kingdom
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Liv Hospital Ankara
Ankara, 06680, Turkey (Türkiye)
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LungenClinic Großhansdorf GmbH
Großhansdorf, 22927, Germany
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Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy
Otwock, 05-400, Poland
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Medikal Park Samsun
Samsun, 55200, Turkey (Türkiye)
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Memorial Ankara Hastanesi
Ankara, 06520, Turkey (Türkiye)
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Mercy Research - St. Louis
St Louis, Missouri, 63141, United States
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National Cheng Kung University Hospital
Tainan, 00704, Taiwan
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New England Cancer Specialists
Scarborough, Maine, 04074, United States
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Niels-Stensen-Kliniken Franziskus-Hospital Harderberg GmbH
Georgsmarienhütte, 49124, Germany
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Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital
Marietta, Georgia, 30060, United States
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Orszagos Koranyi Pulmonologiai Intezet
Budapest, 1121, Hungary
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Pamukkale University School Of Medicine
Denizli, 20070, Turkey (Türkiye)
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Pécsi Tudományegyetem
Pécs, 7623, Hungary
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Rhode Island Hospital
Providence, Rhode Island, 02903, United States
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Samsung Changwon Hospital
Gyeongsangnam-do, 51353, South Korea
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Samsung Medical Center
Seoul, 06351, South Korea
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Sarah Cannon Research Institute / Tennessee Oncology
Nashville, Tennessee, 37203, United States
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Seoul National University Bundang Hospital
Seongnam-si, 13605, South Korea
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Sotiria Thoracic Diseases Hospital of Athens
Athens, 115 27, Greece
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St James University Hospital
Leeds, LS9 7TF, United Kingdom
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TC Necmettin Erbakan University Meram Medical Faculty Hospital
Selçuklu, 42080, Turkey (Türkiye)
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Taichung Veterans General Hospital
Taichung, 407, Taiwan
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Taipei Veterans General Hospital
Taipei, 112, Taiwan
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The Mark H. Zangmeister Ctr
Columbus, Ohio, 43219, United States
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Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi
Edirne, 22030, Turkey (Türkiye)
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Tudogyogyintezet Torokbalint
Törökbálint, 2045, Hungary
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UZ Leuven Gasthuisberg
Leuven, 3000, Belgium
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Ulsan University Hosiptal
Ulsan, 44033, South Korea
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Uludag Uni Hospital
Bursa, 16059, Turkey (Türkiye)
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University Hospital of Larissa
Larissa, 411 10, Greece
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Universitätsklinikum Schleswig-Holstein
Lübeck, 23538, Germany
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Uniwersyteckie Centrum Kliniczne
Gda?sk, 80-214, Poland
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Vall d'Hebron Institute of Oncology (VHIO), Barcelona
Barcelona, 08035, Spain
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Vitaz
Sint-Niklaas, 9100, Belgium
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Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie
Olsztyn, 10-357, Poland
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West Clinic
Germantown, Tennessee, 38138, United States
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Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu
Poznan, 60-569, Poland
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Zentralklinik Bad Berka GmbH
Bad Berka, 99437, Germany
Conditions
Explore the condition pages connected to this study.