New drug combo could extend lives in aggressive lung cancer

NCT ID NCT05091567

Summary

This large Phase 3 trial is testing whether adding the drug lurbinectedin to standard maintenance therapy (atezolizumab) helps people with extensive-stage small-cell lung cancer live longer without their cancer getting worse. The study involves 660 participants whose cancer responded to or remained stable after initial chemotherapy. After that initial treatment, participants are randomly assigned to receive either the two-drug combination or the single drug alone to see which is better at controlling the disease.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • ASL 3 Genovese

    Genoa, Liguria, 16125, Italy

  • AUSL della Romagna

    Ravenna, Emilia-Romagna, 48121, Italy

  • AZ St Maarten Campus Leopoldstr

    Mechelen, 2800, Belgium

  • Ac?badem Altunizade Hastanesi

    Istanbul, 34660, Turkey (Türkiye)

  • Adana Baskent University Hospital

    Adana, 01120, Turkey (Türkiye)

  • Ag. Loukas Hospital

    Thessaloniki, 55236, Greece

  • Ankara City Hospital

    Ankara, 06800, Turkey (Türkiye)

  • Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde

    Morelia, 58260, Mexico

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Asklepios Klinik Gauting

    München-Gauting, 82131, Germany

  • Azienda Ospedaliero Universitaria Ospedali Riuniti

    Torrette Di Ancona, The Marches, 60126, Italy

  • Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda)

    Milan, Lombardy, 20162, Italy

  • Ba?c?lar Medipol Mega Üniversite Hastanesi

    Istanbul, 34214, Turkey (Türkiye)

  • Blackpool Victoria Hospital

    Blackpool, FY3 8NR, United Kingdom

  • CHU UCL Mont-Godinne

    Mont-godinne, 5530, Belgium

  • Cancer & Hematology Centers of Western Michigan

    Grand Rapids, Michigan, 49503, United States

  • Castle Hill Hospital

    Hull, HU16 5JQ, United Kingdom

  • Centrum Onkologii Instytut im.Marii Sklodowskiej-Curie

    Warsaw, 02-781, Poland

  • Chilgok Kyungpook National University Medical Center

    Daegu, 702-210, South Korea

  • Christie NHS Foundation Trust

    GB Manchester, M20 4BX, United Kingdom

  • Chungbuk National University Hospital

    Cheongju-si, 28644, South Korea

  • Clinical Research Alliance

    Westbury, New York, 11590, United States

  • Complejo Hospitalario Universitario A Coruña (CHUAC)

    A Coruña, LA Coruna, 15006, Spain

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Diavalkaniko Hospital

    Thessaloniki, 570 01, Greece

  • E-DA Hospital

    Kaohsiung City, 824, Taiwan

  • Errikos Dynan Hospital

    Athens, 11526, Greece

  • Euromedical General Clinic of Thessaloniki

    Thessaloniki, 546 45, Greece

  • Evang. Lungenklinik Berlin Klinik für Pneumologie

    Berlin, 13125, Germany

  • Fachklinik für Lungenerkrankungen

    Immenhausen, 34376, Germany

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Goztepe Prof.Dr. Suleyman Yalcin City Hospital

    Kadiköy, 34722, Turkey (Türkiye)

  • Greco-Hainesworth Centers for Research

    Chattanooga, Tennessee, 37403, United States

  • Guy's Hospital

    London, SE1 9RT, United Kingdom

  • Gyeongsang National University Hospital

    Gyeongsangnam-do, 52727, South Korea

  • Health Pharma Professional Research

    Mexico City, Mexico CITY (federal District), 03100, Mexico

  • Helios Klinikum Emil von Behring GmbH

    Berlin, 14165, Germany

  • Hollings Cancer Center

    Charleston, South Carolina, 29425, United States

  • Hospital Clinico Universitario Virgen de la Victoria

    Málaga, 29010, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, 41013, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08041, Spain

  • Hospital del Mar

    Barcelona, 08003, Spain

  • Illinois Cancer Care

    Peoria, Illinois, 61615, United States

  • Institut Jules Bordet

    Anderlecht, 1070, Belgium

  • Irccs Istituto Europeo di Oncologia (IEO)

    Milan, Lombardy, 20141, Italy

  • Istanbul Uni Cerrahpasa Medical Faculty Hospital

    Istanbul, 34300, Turkey (Türkiye)

  • Izmir Medical Point Hospital

    Izmir, 35101, Turkey (Türkiye)

  • Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rend.Int.

    Szolnok, 5000, Hungary

  • Jessa Zkh (Campus Virga Jesse)

    Hasselt, 3500, Belgium

  • KEM/Evang. Kliniken Essen Mitte gGmbH

    Essen, 45136, Germany

  • Klinikum Chemnitz gGmbH

    Chemnitz, 09116, Germany

  • Kocaeli University Faculty of Medicine

    İzmit, 31380, Turkey (Türkiye)

  • Krakowski Szpital Specjalistyczny im sw. Jana Paw?a II

    Krakow, 31-202, Poland

  • Krankenhaus Martha-Maria Halle-Doelau gGmbH

    Halle, 06120, Germany

  • Leicester Royal Infirmary

    Leicester, LE1 5WW, United Kingdom

  • Liv Hospital Ankara

    Ankara, 06680, Turkey (Türkiye)

  • LungenClinic Großhansdorf GmbH

    Großhansdorf, 22927, Germany

  • Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy

    Otwock, 05-400, Poland

  • Medikal Park Samsun

    Samsun, 55200, Turkey (Türkiye)

  • Memorial Ankara Hastanesi

    Ankara, 06520, Turkey (Türkiye)

  • Mercy Research - St. Louis

    St Louis, Missouri, 63141, United States

  • National Cheng Kung University Hospital

    Tainan, 00704, Taiwan

  • New England Cancer Specialists

    Scarborough, Maine, 04074, United States

  • Niels-Stensen-Kliniken Franziskus-Hospital Harderberg GmbH

    Georgsmarienhütte, 49124, Germany

  • Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital

    Marietta, Georgia, 30060, United States

  • Orszagos Koranyi Pulmonologiai Intezet

    Budapest, 1121, Hungary

  • Pamukkale University School Of Medicine

    Denizli, 20070, Turkey (Türkiye)

  • Pécsi Tudományegyetem

    Pécs, 7623, Hungary

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Samsung Changwon Hospital

    Gyeongsangnam-do, 51353, South Korea

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Sarah Cannon Research Institute / Tennessee Oncology

    Nashville, Tennessee, 37203, United States

  • Seoul National University Bundang Hospital

    Seongnam-si, 13605, South Korea

  • Sotiria Thoracic Diseases Hospital of Athens

    Athens, 115 27, Greece

  • St James University Hospital

    Leeds, LS9 7TF, United Kingdom

  • TC Necmettin Erbakan University Meram Medical Faculty Hospital

    Selçuklu, 42080, Turkey (Türkiye)

  • Taichung Veterans General Hospital

    Taichung, 407, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

  • The Mark H. Zangmeister Ctr

    Columbus, Ohio, 43219, United States

  • Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi

    Edirne, 22030, Turkey (Türkiye)

  • Tudogyogyintezet Torokbalint

    Törökbálint, 2045, Hungary

  • UZ Leuven Gasthuisberg

    Leuven, 3000, Belgium

  • Ulsan University Hosiptal

    Ulsan, 44033, South Korea

  • Uludag Uni Hospital

    Bursa, 16059, Turkey (Türkiye)

  • University Hospital of Larissa

    Larissa, 411 10, Greece

  • Universitätsklinikum Schleswig-Holstein

    Lübeck, 23538, Germany

  • Uniwersyteckie Centrum Kliniczne

    Gda?sk, 80-214, Poland

  • Vall d'Hebron Institute of Oncology (VHIO), Barcelona

    Barcelona, 08035, Spain

  • Vitaz

    Sint-Niklaas, 9100, Belgium

  • Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie

    Olsztyn, 10-357, Poland

  • West Clinic

    Germantown, Tennessee, 38138, United States

  • Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu

    Poznan, 60-569, Poland

  • Zentralklinik Bad Berka GmbH

    Bad Berka, 99437, Germany

Conditions

Explore the condition pages connected to this study.