New drug trial targets Tough-to-Treat lung cancer after standard therapies fail

NCT ID NCT04619004

Ongoing Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

Summary

This study is testing an experimental drug called patritumab deruxtecan for people with advanced lung cancer that has a specific genetic change (EGFR mutation) and has worsened after trying at least two standard treatments. The main goal is to see how well the drug shrinks tumors and controls the cancer. Researchers are also looking at how long the treatment works and monitoring side effects.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AdventHealth Orlando

Orlando, Florida, 32804, United States
Asan Medical Center

Songpa-gu, Seoul, 05505, South Korea
Azienda Ospedaliero Universitaria di Parma

Parma, Province Of Parma, 43126, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga

Orbassano, Turin, 10043, Italy
Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
Beijing Cancer Hospital

Beijing, 100036, China
Beth Israel Deaconess Medical Center, Harvard Medical School

Boston, Massachusetts, 02215, United States
Blacktown Hospital

Blacktown, New South Wales, 2148, Australia
CHU Toulouse - Hopital Larrey

Toulouse, Haute-Garonne, 31059, France
Catalan Institute of Badalona Hospital Germans Trias i Pujol ICO

Badalona, Cataluã'a, 08916, Spain
Cedars Sinai

West Hollywood, California, 90048, United States
Centre Hospitalier Universitaire de Grenoble

Grenoble, 38043, France
Centre Leon Berard

Lyon, Rhone, 69008, France
Chang Gung Memorial Hospital - Linkou Branch

Taoyuan District, 333, Taiwan
Chang Gung Memorial Hospital CGMH - Kaohsiung Branch

Niaosong, 83301, Taiwan
Chung Shan Medical University Hospital

Taichung, 420, Taiwan
Chungbuk National University Hospital

Cheongju-si, 28644, South Korea
City of Hope

Duarte, California, 91010, United States
Cleveland Clinic - Main Campus

Cleveland, Ohio, 44195, United States
Complex Oncological Center - Russe

Rousse, 7002, Bulgaria
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
E-Da Hospital

Kaohsiung City, 824, Taiwan
Emory University

Dunwoody, Georgia, 30338, United States
Florida Cancer Specialist-North

St. Petersburg, Florida, 33770, United States
Florida Cancer Specialists - South

Fort Myers, Florida, 33901, United States
Florida Cancer Specialists-East

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists-Panhandle

Tallahassee, Florida, 32308, United States
Fondazione IRCCS Istituto Nazionale Tumori

Milan, 20133, Italy
Fudan University - Shanghai Cancer Center FUSCC

Shanghai, 200032, China
General Hospital of Eastern Theater Command

Nanjing, 210002, China
Guangdong Academy of Medical Science (GAMS) - Guangdong Provincial Peoples Hospital

Guangzhou, 510080, China
Gustave Roussy

Villejuif, 94805, France
H. Lee Moffitt Cancer Center & Research Institute

Tampa, Florida, 33612, United States
Harbin Medical University - Tumor Hospital (The Third Affiliated Hospital)

Harbin, 150081, China
Henan Cancer Hospital

Zhengzhou, 450008, China
Henry Ford Cancer Institute/Henry Ford Hospital

Detroit, Michigan, 48202, United States
Hopital Morvan CHU de Brest

Brest, 29609, France
Hopital Pontchaillou

Rennes, 35000, France
Hospital Clinico Universitario Lozano Bleza

Zaragoza, 50009, Spain
Hospital Regional Universitario Carlos Haya

Málaga, 29010, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28040, Spain
Hospital Universitario Puerta de Hierro de Majadahonda

Majadahonda, Madrid, 28222, Spain
Hospital Universitario Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario Virgen Macarena

Seville, Andalusia, 41009, Spain
Humanitas Cancer Center

Rozzano, 20089, Italy
Hyogo Cancer Center

Akashi, Hyōgo, 673-8558, Japan
IRCCS - Istituto Scientifico Romagnolo per lo Studio e La Cura Dei Tumori ISRT

Meldola, 47014, Italy
Institut Curie

Paris, 75248, France
Jilin Cancer Hospital

Changchun, 130012, China
Kansai Medical University Hospital

Hirakata, Osaka, 573-1191, Japan
Karl Landsteiner Institut fÃ¼r Lungenforschung und pneumologische Onkologie c/o Klinik Floridsdorf

Vienna, 1030, Austria
Kindai University Hospital

Ōsaka-sayama, Osaka, 589-8511, Japan
Kliniken der Stadt Koeln gGmbH Lungenklinik Merheim

KÃ¶ln, North Rhine-Westphalia, 51109, Germany
Kliniken der Stadt Koeln gGmbH Lungenklinik Merheim

Cologne, 51109, Germany
Kyungpook National University Chilgok Hospital

Daegu, 41404, South Korea
Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
LungenClinic Grosshansdorf

Großhansdorf, Schleswig-Holstein, 22927, Germany
MD Anderson Cancer Center

Madrid, 28033, Spain
MHAT Serdika

Sofia, 1303, Bulgaria
MHAT Uni Hospital OOD

Panagyurishte, 4500, Bulgaria
MacKay Memorial Hospital

Taipei, 10449, Taiwan
Massachusetts General Hospital (MGH) - Hematology/Oncology

Boston, Massachusetts, 02114, United States
Memorial Healthcare System

Pembroke Pines, Florida, 33021, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Montefiore Medical Center

The Bronx, New York, 10461, United States
Moores Cancer Center at the UC San Diego Health

La Jolla, California, 92093, United States
Mount Sinai Hospital

New York, New York, 10029, United States
National Cancer Center

Goyang-si, 10408, South Korea
National Cancer Center Hospital

Tokyo, Chuo-ku, 104-0045, Japan
National Cancer Center Hospital

Chuo Ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East

Kashiwa, Chiba, 277-0882, Japan
National Cancer Center Hospital East

Chiba, Kashiwa-shi, 277-8577, Japan
National Cancer Centre Singapore NCCS

Singapore, 169610, Singapore
National Cheng Kung University Hospital

Tainan, Tai Nan Shi, 704, Taiwan
National Hospital Organization Hokkaido Cancer Center

Sapporo, Hokkaido, 003-0804, Japan
National Hospital Organization Hokkaido Cancer Center

Sapporo, 003-0804, Japan
National Hospital Organization Kyushu Cancer Center

Fukuoka, 811-1347, Japan
National Hospital Organization Shikoku Cancer Center

Matsuyama, Ehime, 791-0280, Japan
National Taiwan University Hospital NTUH

Taipei, 100, Taiwan
National University Cancer Institute National University Hospital

Singapore, 119074, Singapore
Netherlands Cancer Institute

Amsterdam, 1066CX, Netherlands
Niigata Cancer Center Hospital

Chuo Ku Niigata-shi, 961-8566, Japan
Northwestern University

Chicago, Illinois, 60611, United States
OncoCare Cancer Centre- Gleneagles Medical Centre

Singapore, 258499, Singapore
Pacific Shores Medical Group

Long Beach, California, 90813, United States
Peter MacCallum Cancer Centre

Melbourne, Victoria, 3000, Australia
Princess Alexandra Hospital

Woolloongabba, 4102, Australia
Providence Portland Medical Center

Portland, Oregon, 97213, United States
START Madrid - Hospital Universitario HM Sanchinarro

Madrid, 28050, Spain
Samsung Medical Center

Seoul, 06351, South Korea
Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute at Tennessee Oncology - Chattanooga

Chattanooga, Tennessee, 37404, United States
Sendai Kousei Hospital

Sendai, Miyagi, 980-0873, Japan
Seoul National University Bundang Hospital

Seongnam, 13620, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
Shizuoka Cancer Center

Sunto-gun, Shizuoka, 411-8777, Japan
St George Public Hospital

Kogarah, New South Wales, 2217, Australia
St John of God Subiaco Hospital

Subiaco, Western Australia, 6008, Australia
Taichung Veterans General Hospital

Taichung, 40705, Taiwan
The Cancer Institute Hospital of JFCR

Ariake, Koto, 135-8550, Japan
The Catholic University of Korea, Seoul St. Marys Hospital

Seoul, 06591, South Korea
The Chris O'Brien Lifehouse

Camperdown, New South Wales, 2050, Australia
The Christie Hospital

Manchester, M20 4BX, United Kingdom
The First Affiliated Hospital of College of Medicine Zhejiang University

Hangzhou, 310003, China
The First Hospital of China Medical University

Shenyang, 110001, China
The Royal Marsden NHS Foundation Trust

London, E20 1JQ, United Kingdom
USC Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
Union Hospital of Tongji Medical College Huazhong University of Science and Technology

Wuhan, 430022, China
Universitaet zu Koeln - Uniklinik Koeln

Cologne, North Rhine-Westphal, 50937, Germany
Universitaet zu Koeln - Uniklinik Koeln

Cologne, 50931, Germany
Universitaire Ziekenhuis Gasthuisberg

Leuven, 3000, Belgium
University Cancer Center

Dresden, 01307, Germany
University College London Hospitals

London, NW12PG, United Kingdom
University Hospital Birmingham NHS Trust

Birmingham, B9 5SS, United Kingdom
University Hospital of Nantes - Thoracic Oncology

Nantes, Loire-Atlantique, 44000, France
University of California at Irvine

Orange, California, 92868, United States
University of Colorado Denver - Anschutz Medical Campus

Aurora, Colorado, 80045, United States
University of Electronic Science & Technology of China (UESTC) - Sichuan Cancer Hospital & Institute (Sichuan Provincial Tumor Hospital

Chengdu, 610041, China
University of Maryland - Marlene and Stewart Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Virginia Cancer Center - Emily Couric Clinical Cancer Center

Charlottesville, Virginia, 22903, United States
University of Washington/Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States
Virginia Cancer Specialist, PC

Fairfax, Virginia, 22031, United States

Conditions

Explore the condition pages connected to this study.

NON-SMALL CELL LUNG CANCER METASTATIC NON-SMALL CELL LUNG CANCER WITH MUTATION IN EPIDERMAL GROWTH FACTOR RECEPTOR