Head-to-Head trial aims to find best drug for Tough-to-Treat lung cancer
NCT ID NCT04603807
Summary
This study is comparing two oral medications, entrectinib and crizotinib, for people with advanced non-small cell lung cancer that has a specific genetic change called ROS1. The main goal is to see which drug is better at delaying cancer growth, especially for patients whose cancer has spread to the brain. About 220 participants will take one of the drugs daily until their cancer worsens or side effects become too difficult.
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Contacts and locations
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Locations
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Affiliated Hospital of Jining Medical University
Jining, 272029, China
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All India Institute Of Medical Sciences (AIIMS)
New Delhi, National Capital Territory of Delhi, 110029, India
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Amethyst Cluj
Cluj County, 407280, Romania
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Azienda Ospedaliera San Camillo Forlanini
Rome, Lazio, 00152, Italy
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Azienda Sanitaria Ospedaliera S Luigi Gonzaga
Orbassano, Piedmont, 10043, Italy
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Bangkok Metropolitan Administration Medical College and Vajira Hospital
Wachira Phayaban, 10300, Thailand
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CHRU Lille
Lille, 59037, France
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CHU Rennes - Hopital Pontchaillou
Rennes, 35033, France
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Centre Leon Berard
Lyon, 69008, France
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Centro de Pesquisa e Ensino em Oncologia de Santa Catarina - CEPEN
Florianópolis, Santa Catarina, 88020-210, Brazil
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Centrul de Oncologie Sfantul Nectarie
Craiova, 200542, Romania
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Chulalongkorn Hospital
Bangkok, 10330, Thailand
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Clinical Hospital Centre Zagreb
Zagreb, 10000, Croatia
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Complejo Hospitalario Universitario A Coruña (CHUAC)
A Coruña, 15006, Spain
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Emergency County Clinical Hospital Ploiesti
Ploieşti, Romania
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Erasmus MC
Rotterdam, 3015 GD, Netherlands
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Faculty of Med. Siriraj Hosp.
Bangkok, 10700, Thailand
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Gazi University Medical Faculty, Oncology Hospital
Ankara, 06500, Turkey (Türkiye)
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Guangxi Cancer Hospital of Guangxi Medical University
Nanning, 530021, China
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HELIOS Klinikum Emil von Behring Klinik f.Pneumologie Onkologie u.Infektiologie
Berlin, 14165, Germany
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Harbin Medical University Cancer Hospital
Harbin, 150081, China
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Health Pharma Professional Research
Mexico City, Mexico CITY (federal District), 03100, Mexico
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Hopital Larrey
Toulouse, 31059, France
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Hopital Nord AP-HM
Marseille, 13015, France
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Hopital Robert Schuman
Vantoux, 57070, France
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Hospitais Integrados da Gavea S/A
Brasília, Federal District, 70390-140, Brazil
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Hospital Civil de Guadalajara Fray Antonio Alcalde
Guadalajara, Jalisco, 44280, Mexico
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Hospital Ramon y Cajal
Madrid, 28034, Spain
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Hospital Regional Universitario Carlos Haya
Málaga, 29010, Spain
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Hospital Sao Rafael - HSR
Salvador, Estado de Bahia, 41253-190, Brazil
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Hospital de Cancer de Barretos
Barretos, São Paulo, 14784-400, Brazil
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Hospital del Mar
Barcelona, 08003, Spain
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Hotel Dieu de France
Beirut, Lebanon
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Hunan Cancer Hospital
Changsha, 410013, China
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IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST)
Genoa, Liguria, 16132, Italy
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IRCCS Istituto Oncologico Veneto (IOV)
Padua, Veneto, 35128, Italy
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Institut Bergonie
Bordeaux, 33076, France
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Institut Catala d Oncologia Hospital Duran i Reynals
Barcelona, 08908, Spain
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Instituto do Cancer do Estado de Sao Paulo - ICESP
São Paulo, São Paulo, 01246-000, Brazil
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Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca
Cluj-Napoca, 400015, Romania
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Jilin Cancer Hospital
Changchun, 132013, China
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Karolinska Universitetssjukhuset, Solna
Stockholm, 171 76, Sweden
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King Hussein Cancer Center
Amman, 1269, Jordan
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Liv Hospital Ankara
Ankara, 06680, Turkey (Türkiye)
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MOC Cancer Care & Research Centre (Unit of Cellcure Cancer Centre Pvt Ltd)
Mumbai, Maharashtra, 400036, India
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MVR Cancer Centre and Research Institute
Kozhikode, Kerala, 673601, India
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Mahamana Pandit Madan Mohan Malaviya Cancer Centre-TMC
Varanasi, Uttar Pradesh, 221005, India
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Metropolitan Hospital
Athens, 185 47, Greece
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NKI/AvL
Amsterdam, 1066 CX, Netherlands
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Oncocentro Serviços Médicos e Hospitalares Ltda
Fortaleza, Ceará, 60130-241, Brazil
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Oncoclinicas Rio de Janeiro S.A.
Rio de Janeiro, 22250-905, Brazil
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Pius-Hospital
Oldenburg, 26121, Germany
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Prapokklao Hospital
Chanthaburi, 22000, Thailand
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Shanghai Pulmonary Hospital
Shanghai, 200433, China
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Songklanagarind Hospital
Songkhla, 90110, Thailand
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Taihe Hospital of Hubei University of Medicine
Shiyan, 442000, China
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Tata Medical Center
Kolkata, West Bengal, 700160, India
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The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, 510120, China
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The Second Xiangya Hospital of Central South University
Changsha, 410011, China
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UMC St Radboud
Nijmegen, 6525 GA, Netherlands
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, 430048, China
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Univerzitna nemocnica Bratislava
Bratislava, 826 06, Slovakia
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West China Hospital, Sichuan University
Chengdu, 610041, China
Conditions
Explore the condition pages connected to this study.