Head-to-Head trial aims to find best drug for Tough-to-Treat lung cancer

NCT ID NCT04603807

Summary

This study is comparing two oral medications, entrectinib and crizotinib, for people with advanced non-small cell lung cancer that has a specific genetic change called ROS1. The main goal is to see which drug is better at delaying cancer growth, especially for patients whose cancer has spread to the brain. About 220 participants will take one of the drugs daily until their cancer worsens or side effects become too difficult.

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Contacts and locations

Locations

  • Affiliated Hospital of Jining Medical University

    Jining, 272029, China

  • All India Institute Of Medical Sciences (AIIMS)

    New Delhi, National Capital Territory of Delhi, 110029, India

  • Amethyst Cluj

    Cluj County, 407280, Romania

  • Azienda Ospedaliera San Camillo Forlanini

    Rome, Lazio, 00152, Italy

  • Azienda Sanitaria Ospedaliera S Luigi Gonzaga

    Orbassano, Piedmont, 10043, Italy

  • Bangkok Metropolitan Administration Medical College and Vajira Hospital

    Wachira Phayaban, 10300, Thailand

  • CHRU Lille

    Lille, 59037, France

  • CHU Rennes - Hopital Pontchaillou

    Rennes, 35033, France

  • Centre Leon Berard

    Lyon, 69008, France

  • Centro de Pesquisa e Ensino em Oncologia de Santa Catarina - CEPEN

    Florianópolis, Santa Catarina, 88020-210, Brazil

  • Centrul de Oncologie Sfantul Nectarie

    Craiova, 200542, Romania

  • Chulalongkorn Hospital

    Bangkok, 10330, Thailand

  • Clinical Hospital Centre Zagreb

    Zagreb, 10000, Croatia

  • Complejo Hospitalario Universitario A Coruña (CHUAC)

    A Coruña, 15006, Spain

  • Emergency County Clinical Hospital Ploiesti

    Ploieşti, Romania

  • Erasmus MC

    Rotterdam, 3015 GD, Netherlands

  • Faculty of Med. Siriraj Hosp.

    Bangkok, 10700, Thailand

  • Gazi University Medical Faculty, Oncology Hospital

    Ankara, 06500, Turkey (Türkiye)

  • Guangxi Cancer Hospital of Guangxi Medical University

    Nanning, 530021, China

  • HELIOS Klinikum Emil von Behring Klinik f.Pneumologie Onkologie u.Infektiologie

    Berlin, 14165, Germany

  • Harbin Medical University Cancer Hospital

    Harbin, 150081, China

  • Health Pharma Professional Research

    Mexico City, Mexico CITY (federal District), 03100, Mexico

  • Hopital Larrey

    Toulouse, 31059, France

  • Hopital Nord AP-HM

    Marseille, 13015, France

  • Hopital Robert Schuman

    Vantoux, 57070, France

  • Hospitais Integrados da Gavea S/A

    Brasília, Federal District, 70390-140, Brazil

  • Hospital Civil de Guadalajara Fray Antonio Alcalde

    Guadalajara, Jalisco, 44280, Mexico

  • Hospital Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Regional Universitario Carlos Haya

    Málaga, 29010, Spain

  • Hospital Sao Rafael - HSR

    Salvador, Estado de Bahia, 41253-190, Brazil

  • Hospital de Cancer de Barretos

    Barretos, São Paulo, 14784-400, Brazil

  • Hospital del Mar

    Barcelona, 08003, Spain

  • Hotel Dieu de France

    Beirut, Lebanon

  • Hunan Cancer Hospital

    Changsha, 410013, China

  • IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST)

    Genoa, Liguria, 16132, Italy

  • IRCCS Istituto Oncologico Veneto (IOV)

    Padua, Veneto, 35128, Italy

  • Institut Bergonie

    Bordeaux, 33076, France

  • Institut Catala d Oncologia Hospital Duran i Reynals

    Barcelona, 08908, Spain

  • Instituto do Cancer do Estado de Sao Paulo - ICESP

    São Paulo, São Paulo, 01246-000, Brazil

  • Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca

    Cluj-Napoca, 400015, Romania

  • Jilin Cancer Hospital

    Changchun, 132013, China

  • Karolinska Universitetssjukhuset, Solna

    Stockholm, 171 76, Sweden

  • King Hussein Cancer Center

    Amman, 1269, Jordan

  • Liv Hospital Ankara

    Ankara, 06680, Turkey (Türkiye)

  • MOC Cancer Care & Research Centre (Unit of Cellcure Cancer Centre Pvt Ltd)

    Mumbai, Maharashtra, 400036, India

  • MVR Cancer Centre and Research Institute

    Kozhikode, Kerala, 673601, India

  • Mahamana Pandit Madan Mohan Malaviya Cancer Centre-TMC

    Varanasi, Uttar Pradesh, 221005, India

  • Metropolitan Hospital

    Athens, 185 47, Greece

  • NKI/AvL

    Amsterdam, 1066 CX, Netherlands

  • Oncocentro Serviços Médicos e Hospitalares Ltda

    Fortaleza, Ceará, 60130-241, Brazil

  • Oncoclinicas Rio de Janeiro S.A.

    Rio de Janeiro, 22250-905, Brazil

  • Pius-Hospital

    Oldenburg, 26121, Germany

  • Prapokklao Hospital

    Chanthaburi, 22000, Thailand

  • Shanghai Pulmonary Hospital

    Shanghai, 200433, China

  • Songklanagarind Hospital

    Songkhla, 90110, Thailand

  • Taihe Hospital of Hubei University of Medicine

    Shiyan, 442000, China

  • Tata Medical Center

    Kolkata, West Bengal, 700160, India

  • The First Affiliated Hospital of Guangzhou Medical University

    Guangzhou, 510120, China

  • The Second Xiangya Hospital of Central South University

    Changsha, 410011, China

  • UMC St Radboud

    Nijmegen, 6525 GA, Netherlands

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, 430048, China

  • Univerzitna nemocnica Bratislava

    Bratislava, 826 06, Slovakia

  • West China Hospital, Sichuan University

    Chengdu, 610041, China

Conditions

Explore the condition pages connected to this study.