New drug combo battle for advanced lung cancer shows promise
NCT ID NCT03976323
Summary
This large, completed Phase 3 trial tested two different drug combinations for people with advanced non-squamous non-small cell lung cancer (NSCLC) that had spread. After initial treatment, over 1,000 participants were randomly assigned to receive one of two maintenance therapies to see which was better at controlling the cancer and helping people live longer. The study compared a combination of pembrolizumab (an immunotherapy) with olaparib (a targeted drug) against pembrolizumab with pemetrexed (a standard chemotherapy).
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CARCINOMA, NONSQUAMOUS NON-SMALL-CELL LUNG are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Administradora Country S.A. ( Site 0603)
Bogotá, Bogota D.C., 110221, Colombia
-
Aichi Cancer Center ( Site 0803)
Nagoya, Aichi-ken, 464-8681, Japan
-
Ajou University Hospital ( Site 1004)
Suwon, Kyonggi-do, 16499, South Korea
-
Alabama Oncology Bruno Cancer Center ( Site 0001)
Birmingham, Alabama, 35205, United States
-
Ankara Bilkent Sehir Hastanesi ( Site 2105)
Ankara, 06800, Turkey (Türkiye)
-
Asan Medical Center ( Site 1007)
Songpa-gu, Seoul, 05505, South Korea
-
BC Cancer - Victoria ( Site 0109)
Victoria, British Columbia, V8R 6V5, Canada
-
BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 0214)
São Paulo, 01321-001, Brazil
-
Barbara Ann Karmanos Cancer Institute ( Site 0041)
Detroit, Michigan, 48201, United States
-
Barts Health NHS Trust - St Bartholomew s Hospital ( Site 1923)
London, London, City of, EC1M 6BQ, United Kingdom
-
Baskent Unv. Adana Uyg. ve Arast. Hastanesi ( Site 2101)
Adana, 01120, Turkey (Türkiye)
-
Bezmialem Vakif Univ. Tıp Fakultesi Hastanesi Tibbi Onkoloji Bolumu ( Site 2107)
Istanbul, 34093, Turkey (Türkiye)
-
Birmingham Heartlands Hospital ( Site 1910)
Birmingham, B9 5SS, United Kingdom
-
Boca Raton Regional Hospital ( Site 0018)
Boca Raton, Florida, 33486, United States
-
Bozeman Health Deaconness Cancer Center ( Site 0046)
Bozeman, Montana, 59715, United States
-
Budgetary Healthcare Institution of Omsk Region Clinical Oncology Dispensary-Chemotherapy #1 ( Site 2010)
Omsk, Omsk Oblast, 644013, Russia
-
CHU Angers ( Site 1405)
Angers, Maine-et-Loire, 49100, France
-
CHU Caen ( Site 1406)
Caen, Calvados, 14033, France
-
CHU de Rouen ( Site 1403)
Rouen, Seine-Maritime, 76000, France
-
CISSS de la Monteregie-Centre ( Site 0114)
Greenfield Park, Quebec, J4V 2H1, Canada
-
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0110)
Montreal, Quebec, H3T 1M5, Canada
-
CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0103)
Sherbrooke, Quebec, J1H 5N4, Canada
-
CNPE "Regional Center of Oncology"-Thoracic organs ( Site 2205)
Kharkiv, Kharkivs’ka Oblast’, 61070, Ukraine
-
Cancer Care Northwest ( Site 0071)
Spokane Valley, Washington, 99216, United States
-
Cancer Institute Hospital of JFCR ( Site 0800)
Tokyo, 135-8550, Japan
-
Capital & Coast District Health Board - Wellington Hospital ( Site 1101)
Wellington, 6021, New Zealand
-
Cardiomed SRL Cluj-Napoca ( Site 2504)
Cluj-Napoca, Cluj, 400015, Romania
-
Central City Clinical Hospital ( Site 2207)
Uzhhorod, Zakarpattia Oblast, 88000, Ukraine
-
Centre Hospitalier De Chauny ( Site 1411)
Chauny, Aisne, 02300, France
-
Centre Hospitalier de Pau ( Site 1412)
Pau, Pyrenees-Atlantiques, 64000, France
-
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0105)
Montreal, Quebec, H2X 3E4, Canada
-
Centre Jean Perrin ( Site 1407)
Clermont-Ferrand, Puy-de-Dome, 63011, France
-
Centre de Sante et des Services Sociaux de Rimouski-Neigette ( Site 0104)
Rimouski, Quebec, G5L 5T1, Canada
-
Centro Medico San Roque ( Site 0506)
San Miguel de Tucumán, Tucumán Province, T4000IAK, Argentina
-
Centro Oncológico de Rosario ( Site 0507)
Rosario, Santa Fe Province, S2000KZE, Argentina
-
Centro de Hematologia e Oncologia ( Site 0205)
Joinville, Santa Catarina, 89201-260, Brazil
-
Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 0202)
Itajaí, Santa Catarina, 88301-220, Brazil
-
Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0907)
Kaohsiung City, 833, Taiwan
-
Chang Gung Medical Foundation.Linkou Branch ( Site 0903)
Taoyuan District, 333, Taiwan
-
Chelsea and Westminster Hospital ( Site 1901)
London, London, City of, SW10 9NH, United Kingdom
-
Cherkasy Regional Oncology Dispensary ( Site 2211)
Cherkasy, Cherkasy Oblast, 18009, Ukraine
-
China Medical University Hospital ( Site 0904)
Taichung, 40447, Taiwan
-
Chungbuk National University Hospital ( Site 1002)
Cheongju-si, North Chungcheong, 28644, South Korea
-
Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 0601)
Bogotá, Bogota D.C., 111321, Colombia
-
Clinica de la Costa S.A.S. ( Site 0608)
Barranquilla, Atlántico, 080020, Colombia
-
Clínica Universitaria Reina Fabiola ( Site 0505)
Córdoba, X5004SHP, Argentina
-
Colchester General Hospital ( Site 1911)
Colchester, Worcestershire, CO4 5JL, United Kingdom
-
Columbus Regional Research Institute ( Site 0098)
Columbus, Georgia, 31904, United States
-
Disney Family Cancer Center ( Site 0005)
Burbank, California, 91505, United States
-
Ege Universitesi Tip Fakultesi ( Site 2109)
Izmir, 35040, Turkey (Türkiye)
-
Erciyes Universitesi Tip Fakultesi ( Site 2108)
Kayseri, 38039, Turkey (Türkiye)
-
FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 2006)
Moscow, Moscow, 125367, Russia
-
First Moscow State Medical University n.a. I.M.Sechenov ( Site 2024)
Moscow, Moscow, 119991, Russia
-
Frontier Oncology ( Site 0080)
Billings, Montana, 59102, United States
-
Fundacion Colombiana de Cancerologia Clinica Vida ( Site 0604)
Medellín, Antioquia, 050030, Colombia
-
Gazi Universitesi Tip Fakultesi ( Site 2104)
Ankara, 06500, Turkey (Türkiye)
-
Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2212)
Kharkiv, Kharkivs’ka Oblast’, 61024, Ukraine
-
Gyeongsang National University Hospital ( Site 1005)
Jinju, Kyongsangnam-do, 52727, South Korea
-
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2103)
Istanbul, 34722, Turkey (Türkiye)
-
Hattiesburg Clinic ( Site 0045)
Hattiesburg, Mississippi, 39401, United States
-
Health Sciences North Research Institute ( Site 0115)
Greater Sudbury, Ontario, P3E 5J1, Canada
-
Helios Klinikum Erfurt GmbH ( Site 1502)
Erfurt, Thuringia, 99089, Germany
-
Hopital Robert Schuman ( Site 1402)
Vantoux, Moselle, 57070, France
-
Hopital d'Instruction des Armees Begin ( Site 1413)
Saint-Mandé, Val-de-Marne, 94163, France
-
Hospital Britanico de Buenos Aires ( Site 0500)
Ciudad Autónoma de Buenos Aires, Buenos Aires, C1280AEB, Argentina
-
Hospital Clinico Lozano Blesa ( Site 1700)
Zaragoza, 50009, Spain
-
Hospital Clinico Universitario de Valencia ( Site 1706)
Valencia, Valenciana, Comunitat, 46010, Spain
-
Hospital Italiano Regional del Sur ( Site 0509)
Bahía Blanca, Buenos Aires, B8001HXM, Argentina
-
Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0511)
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1199ABB, Argentina
-
Hospital Paulistano - Amil Clinical Research ( Site 0207)
São Paulo, 01321-001, Brazil
-
Hospital Sao Rafael ( Site 0212)
Salvador, Estado de Bahia, 41253-190, Brazil
-
Hospital Tacchini ( Site 0208)
Bento Gonçalves, Rio Grande do Sul, 95700-000, Brazil
-
Hospital Universitario Nuestra Senora de Valme ( Site 1703)
Seville, 41014, Spain
-
Hospital Universitario Quiron Madrid ( Site 1701)
Pozuelo de Alarcón, Madrid, 28223, Spain
-
Hospital de Base de Sao Jose de Rio Preto ( Site 0204)
Sao Jose Rio Preto, São Paulo, 15080-000, Brazil
-
Hospital del Mar ( Site 1702)
Barcelona, 08003, Spain
-
InVo-Institut fuer Versorgungsforschung in der Onkologie ( Site 1514)
Koblenz, Rhineland-Palatinate, 56068, Germany
-
Innsbruck LKH ( Site 1302)
Innsbruck, Tyrol, 6020, Austria
-
Institut De Cancerologie De Lorraine ( Site 1409)
Vandœuvre-lès-Nancy, Ain, 54519, France
-
Instituto Medico Rio Cuarto ( Site 0501)
Río Cuarto, Córdoba Province, X5800AEV, Argentina
-
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0203)
Rio de Janeiro, 20231-050, Brazil
-
Instituto do Cancer do Ceara ( Site 0201)
Fortaleza, Ceará, 60351-030, Brazil
-
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0200)
São Paulo, 01246-000, Brazil
-
Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 0209)
Porto Alegre, Rio Grande do Sul, 90050-170, Brazil
-
Kanagawa Cancer Center ( Site 0807)
Yokohama, Kanagawa, 241-8515, Japan
-
Kanazawa University Hospital ( Site 0811)
Kanazawa, Ishikawa-ken, 920-8641, Japan
-
Kansai Medical University Hospital ( Site 0804)
Hirakata, Osaka, 573-1191, Japan
-
Katholisches Marienkrankenhaus gGmbH ( Site 1522)
Hamburg, 22087, Germany
-
Kliniken Essen Mitte ( Site 1517)
Essen, North Rhine-Westphalia, 45136, Germany
-
Klinikum Bogenhausen Staedt. Klinikum Muenchen GmbH ( Site 1523)
Munich, Bavaria, 81925, Germany
-
Klinikum Wels-Grieskirchen ( Site 1304)
Wels, Upper Austria, 4600, Austria
-
Klinikum Wuerzburg Mitte gGmbH ( Site 1509)
Würzburg, Bavaria, 97074, Germany
-
Klinikum der LMU ( Site 1500)
Munich, Bavaria, 80336, Germany
-
Korea University Guro Hospital ( Site 1008)
Seoul, 08308, South Korea
-
Krakowski Szpital Specjalistyczny im Jana Pawla II ( Site 2420)
Krakow, Lesser Poland Voivodeship, 31-202, Poland
-
Krankenhaus Nord - Klinik Floridsdorf ( Site 1300)
Vienna, 1210, Austria
-
Kyiv City Clinical Oncology Centre ( Site 2210)
Kyiv, 03115, Ukraine
-
Lions Gate Hospital ( Site 0106)
North Vancouver, British Columbia, V7L 2L7, Canada
-
Liverpool Hospital ( Site 1201)
Liverpool, New South Wales, 2170, Australia
-
MED-POLONIA Sp. z o.o. ( Site 2419)
Poznan, Greater Poland Voivodeship, 61-693, Poland
-
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 2502)
Bucharest, București, 013823, Romania
-
MI Odessa Regional Oncological Centre ( Site 2208)
Odesa, Odesa Oblast, 65055, Ukraine
-
MI Precarpathian Clinical Oncology Center ( Site 2204)
Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine
-
Mackay Memorial Hospital ( Site 0902)
Taipei, 104, Taiwan
-
Medical Center Asklepion LLC ( Site 2234)
Khodosovka, Kyivska Oblast, 08173, Ukraine
-
Medical Center Verum ( Site 2230)
Kyiv, Kyivska Oblast, 03039, Ukraine
-
Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 2213)
Kyiv, Kyivska Oblast, 03126, Ukraine
-
Medstar Good Samaritan Hospital ( Site 0040)
Baltimore, Maryland, 21239, United States
-
Methodists Hospitals/Premier Oncology Hematology Associates ( Site 0036)
Merrillville, Indiana, 46410, United States
-
Mid-Florida Cancer Centers ( Site 0022)
Orange City, Florida, 32763, United States
-
MidCentral DHB Palmerston North Hospital ( Site 1102)
Palmerston North, Manawatu-Wanganui, 4414, New Zealand
-
Moffitt Cancer Center ( Site 0024)
Tampa, Florida, 33612, United States
-
Monash Cancer Centre ( Site 1205)
Clayton, Victoria, 3168, Australia
-
Moscow Regional Oncological Dispensary ( Site 2028)
Balashikha, Moscow Oblast, 143900, Russia
-
Moscow Research Oncology Institute named after P.A. Hertsen ( Site 2009)
Moscow, Moscow, 125284, Russia
-
Mount Sinai Hospital Medical Center ( Site 0032)
Chicago, Illinois, 60608, United States
-
Municipal Non-Profit Enterprise City Clinical Hospital 4 of Dnipro City Council ( Site 2201)
Dnipro, Dnipropetrovsk Oblast, 49102, Ukraine
-
Namik Kemal Universitesi Tip Fakultesi ( Site 2100)
Tekirdağ, Tekirdas, 59100, Turkey (Türkiye)
-
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 2418)
Warsaw, Masovian Voivodeship, 02-781, Poland
-
National Cancer Center ( Site 1006)
Goyang-si, Kyonggi-do, 10408, South Korea
-
National Cancer Center Hospital East ( Site 0801)
Kashiwa, Chiba, 2778577, Japan
-
National Cheng Kung University Hospital ( Site 0905)
Tainan, 70457, Taiwan
-
National Hospital Organization Kinki-chuo Chest Medical Center ( Site 0813)
Sakai, Osaka, 591-8555, Japan
-
National Hospital Organization Kyushu Medical Center ( Site 0805)
Fukuoka, 8108563, Japan
-
National Hospital Organization Nagoya Medical Center ( Site 0806)
Nagoya, Aichi-ken, 460-0001, Japan
-
National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 2004)
Saint Petersburg, Sankt-Peterburg, 197758, Russia
-
National Taiwan University Hospital ( Site 0900)
Taipei, 100, Taiwan
-
Niigata Cancer Center Hospital ( Site 0808)
Niigata, 951-8566, Japan
-
Nizhniy Novgorod Region Oncology Dispensary ( Site 2026)
Nizhny Novgorod, Nizhny Novgorod Oblast, 603081, Russia
-
Northwest Alabama Cancer Center, PC ( Site 0002)
Muscle Shoals, Alabama, 35661, United States
-
Okayama University Hospital ( Site 0810)
Okayama, 700-8558, Japan
-
Oncologica do Brasil ( Site 0210)
Belém, Pará, 66053-000, Brazil
-
Oncology of Northshore ( Site 0033)
Rolling Meadows, Illinois, 60008, United States
-
Ondokuz Mayıs Universitesi-Oncology department ( Site 2106)
Samsun, 55139, Turkey (Türkiye)
-
Ordensklinikum Linz GmbH Elisabethinen ( Site 1307)
Linz, Upper Austria, 4020, Austria
-
Osaka International Cancer Institute ( Site 0809)
Osaka, 541-8567, Japan
-
Ovidius Clinical Hospital OCH ( Site 2501)
Ovidiu, Constanța County, 905900, Romania
-
PP PPC Acinus Medical and Diagnostic Centre ( Site 2209)
Kropyvnitskiy, Kirovohrad Oblast, 25006, Ukraine
-
Pneumologische Lehrklinik Universitaet Goettingen ( Site 1501)
Immenhausen, Hesse, 34376, Germany
-
Policlinica Oncomed SRL ( Site 2505)
Timișoara, Timiș County, 300239, Romania
-
Przychodnia Lekarska Komed ( Site 2416)
Konin, Greater Poland Voivodeship, 62-500, Poland
-
Queen Elizabeth II Health Sciences Centre ( Site 0107)
Halifax, Nova Scotia, B3H 2Y9, Canada
-
Renovatio Clinical ( Site 0062)
The Woodlands, Texas, 77380, United States
-
Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 2021)
Kazan', Tatarstan, Respublika, 420029, Russia
-
Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 2000)
Moscow, Moscow, 115478, Russia
-
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2508)
Craiova, Dolj, 200542, Romania
-
S.C. Radiotherapy Center Cluj S.R.L ( Site 2507)
Cluj-Napoca, Cluj, 407280, Romania
-
SBHI Leningrad Regional Clinical Hospital ( Site 2002)
Saint Petersburg, Sankt-Peterburg, 194291, Russia
-
SBHI Samara Regional Clinical Oncology Dispensary ( Site 2016)
Samara, Samara Oblast, 443031, Russia
-
SPb Central Clinical Railway Hospital ( Site 2003)
Saint Petersburg, Sankt-Peterburg, 195271, Russia
-
SPb SBHI City Clinical Oncological Dispensary ( Site 2001)
Saint Petersburg, Sankt-Peterburg, 198255, Russia
-
Saint Gallen Instituto de Oncologia ( Site 0206)
Santa Cruz do Sul, Rio Grande do Sul, 96810-110, Brazil
-
Sanatorio Privado San Geronimo S.R.L ( Site 0510)
Santa Fe, S3000AOL, Argentina
-
Sendai Kousei Hospital ( Site 0812)
Sendai, Miyagi, 981-0914, Japan
-
Seoul National University Hospital ( Site 1000)
Seoul, 03080, South Korea
-
Shizuoka Cancer Center ( Site 0802)
Suntogun, Shizuoka, 411-8777, Japan
-
Singleton Hospital ( Site 1909)
Swansea, Wales, SA2 8QA, United Kingdom
-
Social Medical Center - Otto Wagner Hospital ( Site 1301)
Vienna, Vienna, 1145, Austria
-
Southern Medical Day Care Centre ( Site 1200)
Wollongong, New South Wales, 2500, Australia
-
Spitalul PDR Medlife ( Site 2509)
Brasov, 500152, Romania
-
Stronach Regional Cancer Centre ( Site 0101)
Newmarket, Ontario, L3Y 2P9, Canada
-
Studienzentrum Aschaffenburg ( Site 1525)
Aschaffenburg, Bavaria, 63739, Germany
-
Szpital Rejonowy im. dr Jozefa Rostka ( Site 2402)
Racibórz, Silesian Voivodeship, 47-400, Poland
-
The Catholic University of Korea St. Vincent s Hospital ( Site 1003)
Suwon, Kyonggi-do, 16247, South Korea
-
Thompson Cancer Survival Center ( Site 2812)
Knoxville, Tennessee, 37916, United States
-
Townsville General Hospital ( Site 1202)
Townsville, Queensland, 4814, Australia
-
Universitaetsklinikum Bonn ( Site 1524)
Bonn, North Rhine-Westphalia, 53127, Germany
-
Universitaetsklinikum Frankfurt ( Site 1513)
Frankfurt am Main, Hesse, 60590, Germany
-
Universitaetsklinikum Regensburg ( Site 1512)
Regensburg, Bavaria, 93053, Germany
-
Universitaetsmedizin Goettingen ( Site 1507)
Göttingen, Lower Saxony, 37075, Germany
-
University of Tennessee Medical Center Knoxville ( Site 0060)
Knoxville, Tennessee, 37920, United States
-
Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie ( Site 2417)
Olsztyn, Warmian-Masurian Voivodeship, 10-357, Poland
-
Waterloo Regional Health Network (WRHN) ( Site 0117)
Kitchener, Ontario, N2G 1G3, Canada
-
Waverly Hematology Oncology ( Site 0081)
Cary, North Carolina, 27518, United States
-
West Suffolk Hospitals NHS Trust ( Site 1919)
Bury St Edmunds, Suffolk, IP33 2QZ, United Kingdom
-
Western General Hospital, Edinburgh ( Site 1924)
Edinburgh, United Kingdom, EH4 2XU, United Kingdom
-
Wielospecjalistyczny Szpital SPZOZ w Zgorzelcu ( Site 2404)
Zgorzelec, Lower Silesian Voivodeship, 59-900, Poland
-
YNOVA Pesquisa Clinica ( Site 0215)
Florianópolis, Santa Catarina, 88020-210, Brazil
Conditions
Explore the condition pages connected to this study.