Major trial tests powerful combo to fight advanced lung cancer

NCT ID NCT03829332

Summary

This large, completed Phase 3 trial tested whether adding a drug called lenvatinib to a standard immunotherapy (pembrolizumab) was better than the immunotherapy alone for people with advanced non-small cell lung cancer who had not yet received treatment. It involved 623 adults and aimed to see if the combination helped patients live longer without their cancer getting worse and improved their overall survival.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • 1st Affil Hosp of Med College of Xi'an Jiaotong University ( Site 0103)

    XiAn, Shanxi, 710061, China

  • 2nd Affil Hosp of Zhejiang University College of Medicine ( Site 0114)

    Hangzhou, Zhejiang, 310009, China

  • A.O. Universitaria Careggi ( Site 0236)

    Florence, 50134, Italy

  • AS Ida-Tallinna Keskhaigla ( Site 0161)

    Tallinn, Harju, 11312, Estonia

  • Abdurrahman Yurtaslan Onkoloji Hastanesi ( Site 0318)

    Ankara, 06200, Turkey (Türkiye)

  • Aichi Cancer Center Hospital ( Site 0018)

    Nagoya, Aichi-ken, 464-8681, Japan

  • Akdeniz Universitesi Tip Fakultesi ( Site 0322)

    Antalya, 07070, Turkey (Türkiye)

  • Alaska Clinical Research Center ( Site 0511)

    Anchorage, Alaska, 99503, United States

  • Anhui Provincial Hospital ( Site 0108)

    Hefei, Anhui, 230001, China

  • Anne Arundel Medical Center Oncology and Hematology ( Site 0514)

    Annapolis, Maryland, 21401, United States

  • Antalya Memorial Hospital Department of Medical Oncology ( Site 0324)

    Antalya, 07020, Turkey (Türkiye)

  • Ars Medical Sp. z o.o. ( Site 0254)

    Piła, Greater Poland Voivodeship, 64-920, Poland

  • Asan Medical Center ( Site 0076)

    Seoul, 05505, South Korea

  • Azienda Ospedaliera S. Giovanni Addolorata-Oncologia Medica ( Site 0233)

    Rome, Lazio, 00185, Italy

  • Azienda Ospedaliera San Giuseppe Moscati ( Site 0234)

    Avellino, 83100, Italy

  • Ballarat Oncology and Haematology Services ( Site 0008)

    Wendouree, Victoria, 3355, Australia

  • Barzilai Medical Center ( Site 0226)

    Ashkelon, Ḥeifā, 7830604, Israel

  • Baskent Universitesi Ankara Hastanesi ( Site 0319)

    Ankara, 06490, Turkey (Türkiye)

  • Beacon Hospital Sdn Bhd ( Site 0067)

    Petaling Jaya, Selangor, 46050, Malaysia

  • Beijing Cancer Hospital ( Site 0102)

    Beijing, Beijing Municipality, 100036, China

  • Beijing Chest Hospital Capital Medical University ( Site 0111)

    Beijing, Anhui, 101149, China

  • Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 0207)

    Gyula, Bekes County, 5700, Hungary

  • Billings Clinic Cancer Center ( Site 0508)

    Billings, Montana, 59101, United States

  • Biomelab S A S ( Site 0365)

    Barranquilla, Atlántico, 080002, Colombia

  • Bnei Zion Medical Center ( Site 0227)

    Haifa, Heifa, 3339419, Israel

  • Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz ( Site 0202)

    Miskolc, Borsod-Abauj Zemplen county, 3529, Hungary

  • CBCC Global Research, Inc. ( Site 0532)

    Bakersfield, California, 93309, United States

  • CHU Amiens Sud ( Site 0182)

    Amiens, Somme, 80054, France

  • CHU Jean Minjoz ( Site 0167)

    Besançon, Doubs, 25000, France

  • CHU de Grenoble - Hopital Michallon ( Site 0169)

    La Tronche, Isere, 38700, France

  • CHU de Rouen ( Site 0174)

    Rouen, Seine-Maritime, 76000, France

  • CRU Hungary KFT ( Site 0209)

    Miskolc, Borsod-Abauj Zemplen county, 3529, Hungary

  • Central Texas Veterans Healthcare System ( Site 0533)

    Temple, Texas, 76504, United States

  • Centre Hospitalier de la Cote Basque ( Site 0173)

    Bayonne, Pyrenees-Atlantiques, 64109, France

  • Centre hospitalier Toulon Sainte-Musse ( Site 0172)

    Toulon, Var, 83056, France

  • Centro Medico Imbanaco de Cali S.A ( Site 0369)

    Cali, Valle del Cauca Department, 760023, Colombia

  • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 0381)

    Madero, Tamaulipas, 89440, Mexico

  • Centro di Riferimento Oncologico CRO ( Site 0235)

    Aviano, Pordenone, 33081, Italy

  • Centrum Medyczne Pratia Ostroleka ( Site 0242)

    Ostrołęka, Masovian Voivodeship, 07-410, Poland

  • Cherkasy Regional Hospital ( Site 0336)

    Cherkasy, Cherkasy Oblast, 18009, Ukraine

  • Chungbuk National University Hospital ( Site 0079)

    Cheongju-si, North Chungcheong, 28644, South Korea

  • City Clinical Hosp.4 of DCC ( Site 0338)

    Dnipro, Dnipropetrovsk Oblast, 49102, Ukraine

  • City Clinical Oncology Center ( Site 0260)

    Saint Petersburg, Sankt-Peterburg, 198255, Russia

  • Cone Health Cancer Center at Alamance Regional ( Site 0527)

    Greensboro, North Carolina, 27403, United States

  • Consultorios de Medicina Especializada del Sector Privado ( Site 0388)

    Guadalajara, Jalisco, 44680, Mexico

  • Cross Cancer Institute ( Site 0400)

    Edmonton, Alberta, T6G 1Z2, Canada

  • Dokuz Eylul Universitesi Arastirma Uygulama Hastanesi ( Site 0314)

    Izmir, 35340, Turkey (Türkiye)

  • Florida Hospital ( Site 0526)

    Orlando, Florida, 32803, United States

  • Fundacion Centro de Investigacion Clinica CIC ( Site 0366)

    Medellín, Antioquia, 050021, Colombia

  • Genesis Cancer Care Center ( Site 0559)

    Zanesville, Ohio, 43701, United States

  • Gleneagles Penang ( Site 0066)

    Pulau Pinang, 10050, Malaysia

  • Gulhane Egitim ve Arastirma Hastanesi ( Site 0316)

    Ankara, 06010, Turkey (Türkiye)

  • Hangzhou First People's Hospital ( Site 0109)

    Hangzhou, Zhejiang, 310006, China

  • Hospital General de Medellin Luz Castro de Gutierrez ( Site 0368)

    Medellín, Antioquia, 050015, Colombia

  • Hospital Pulau Pinang. ( Site 0065)

    George Town, Pulau Pinang, 10990, Malaysia

  • Hospital Tengku Ampuan Afzan ( Site 0062)

    Kuantan, Pahang, 25100, Malaysia

  • Hunan Cancer Hospital ( Site 0104)

    Changsha, Hunan, 410013, China

  • Hyogo Cancer Center ( Site 0021)

    Akashi, Hyōgo, 673-8558, Japan

  • ICM Val D Auerelle ( Site 0177)

    Montpellier, Herault, 34090, France

  • Illinois Cancer Care, PC ( Site 0557)

    Peoria, Illinois, 61615, United States

  • Institut Curie ( Site 0166)

    Paris, 75248, France

  • Institut Curie - Centre Rene Huguenin ( Site 0181)

    Saint-Cloud, Hauts-de-Seine, 92210, France

  • Institut Kanser Negara - National Cancer Institute ( Site 0063)

    Putrajaya, Putrajaya, 62250, Malaysia

  • Institut de Cancerologie de l Ouest Centre Rene Gauducheau ( Site 0185)

    Saint-Herblain, Loire-Atlantique, 44805, France

  • Instituto Nacional de Cancerologia. ( Site 0382)

    Mexico City, 14080, Mexico

  • Ironwood Cancer & Research Centers ( Site 0541)

    Chandler, Arizona, 85224, United States

  • Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 0203)

    Szolnok, Jász-Nagykun-Szolnok, 5000, Hungary

  • Jiangsu Cancer Hospital ( Site 0101)

    Nanjing, Jiangsu, 210009, China

  • Juntendo University Hospital ( Site 0029)

    Tokyo, 113-8431, Japan

  • Kanagawa Cancer Center ( Site 0023)

    Yokohama, Kanagawa, 241-8515, Japan

  • Kanagawa Cardiovascular and Respiratory Center ( Site 0026)

    Yokohama, Kanagawa, 236-0051, Japan

  • Kindai University Hospital ( Site 0017)

    Sayama, Osaka, 589-8511, Japan

  • Koo Foundation Sun Yat-Sen Cancer Center ( Site 0091)

    Taipei, 112, Taiwan

  • Krakowski Szpital Specjalistyczny im Jana Pawla II ( Site 0253)

    Krakow, Lesser Poland Voivodeship, 31-202, Poland

  • Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0266)

    Krasnoyarsk, Krasnoyarsk Krai, 660133, Russia

  • Kurume University Hospital ( Site 0025)

    Kurume, Fukuoka, 830-0011, Japan

  • Kyiv City Clinical Oncology Centre ( Site 0339)

    Kyiv, Kyivska Oblast, 03115, Ukraine

  • Kyushu University Hospital ( Site 0030)

    Fukuoka, 812-8582, Japan

  • Lions Gate Hospital ( Site 0407)

    North Vancouver, British Columbia, V7L 2L7, Canada

  • Lviv State Oncology Regional Treatment and Diagnostic Center ( Site 0341)

    Lviv, Lviv Oblast, 79031, Ukraine

  • MI Odessa Regional Oncological Centre ( Site 0333)

    Odesa, Odesa Oblast, 65055, Ukraine

  • MI Precarpathian Clinical Oncology Center ( Site 0346)

    Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine

  • McGill University Health Centre ( Site 0418)

    Montreal, Quebec, H4A 3J1, Canada

  • Medica Sur S.A.B de C.V. ( Site 0384)

    Mexico City, Mexico City, 14050, Mexico

  • Medical Center Verum ( Site 0334)

    Kyiv, Kyivska Oblast, 03039, Ukraine

  • Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 0331)

    Kyiv, Kyivska Oblast, 03126, Ukraine

  • Meir Medical Center ( Site 0221)

    Kfar Saba, 4428132, Israel

  • Miyagi Cancer Center ( Site 0028)

    Natori-shi, Miyagi, 981-1293, Japan

  • Munson Medical Center ( Site 0512)

    Traverse City, Michigan, 49684, United States

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0252)

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • National Cheng Kung University Hospital ( Site 0086)

    Tainan, 70457, Taiwan

  • National Hospital Organization Kinki-chuo Chest Medical Center ( Site 0027)

    Sakai, Osaka, 591-8555, Japan

  • National Hospital Organization Kyushu Medical Center ( Site 0015)

    Fukuoka, 810-8563, Japan

  • National Taiwan University Hospital ( Site 0088)

    Taipei, 10002, Taiwan

  • National Taiwan University Hospital Hsin-Chu Branch ( Site 0087)

    Hsinchu, 300, Taiwan

  • Necmettin Erbakan Universitesi Meram Tip Fakultesi ( Site 0321)

    Konya, Adana, 42080, Turkey (Türkiye)

  • Nippon Medical School Hospital ( Site 0024)

    Tokyo, 113-8603, Japan

  • Northwest Georgia Oncology Centers PC ( Site 0518)

    Marietta, Georgia, 30060, United States

  • Oaxaca Site Management Organization SC ( Site 0389)

    Oaxaca City, 68000, Mexico

  • Okayama University Hospital ( Site 0020)

    Okayama, 700-8558, Japan

  • Oncomedica S.A. ( Site 0372)

    Montería, Departamento de Córdoba, 230002, Colombia

  • Orange Health Services ( Site 0002)

    Orange, New South Wales, 2800, Australia

  • Oregon Health Sciences University ( Site 0544)

    Portland, Oregon, 97239, United States

  • Osaka International Cancer Institute ( Site 0019)

    Osaka, 541-8567, Japan

  • Ospedale Santa Maria delle Croci ( Site 0232)

    Ravenna, 48121, Italy

  • Park Nicollet Frauenshuh Cancer Center ( Site 0554)

    Saint Louis Park, Minnesota, 55426, United States

  • Parkview Cancer Center ( Site 0542)

    Fort Wayne, Indiana, 46845, United States

  • Peking Union Medical College Hospital ( Site 0105)

    Beijing, Beijing Municipality, 100006, China

  • Petz Aladar Megyei Oktato Korhaz ( Site 0213)

    Győr, Győr-Moson-Sopron, 9024, Hungary

  • Podillya Regional Center of Oncology ( Site 0343)

    Vinnytsia, Vinnytsia Oblast, 21029, Ukraine

  • Policlinico Gemelli di Roma ( Site 0237)

    Roma, 00168, Italy

  • Presidio Ospedaliero San Vincenzo ( Site 0231)

    Taormina, Messina, 98039, Italy

  • Rabin Medical Center ( Site 0224)

    Petah Tikva, 4941492, Israel

  • Railway Hospital of OJSC ( Site 0268)

    Saint Petersburg, Sankt-Peterburg, 195271, Russia

  • Rambam Medical Center ( Site 0223)

    Haifa, 3109601, Israel

  • Regional Centre of Oncology-Thoracic organs ( Site 0337)

    Kharkiv, Kharkivs’ka Oblast’, 61070, Ukraine

  • Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 0262)

    Ufa, Baskortostan, Respublika, 450054, Russia

  • Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 0269)

    Kazan', Tatarstan, Respublika, 420029, Russia

  • SA Pohja-Eesti Regionaalhaigla ( Site 0162)

    Tallinn, Harju, 13419, Estonia

  • SA Tartu Ulikooli Kliinikum ( Site 0160)

    Tartu, Tartu, 50406, Estonia

  • SBHI Leningrad Regional Clinical Hospital ( Site 0263)

    Saint Petersburg, Sankt-Peterburg, 194291, Russia

  • SBHI Samara Regional Clinical Oncology Dispensary ( Site 0265)

    Samara, Samara Oblast, 443031, Russia

  • SMG-SNU Boramae Medical Center ( Site 0078)

    Seoul, 07061, South Korea

  • SPZOZ USK nr 1 im. Norberta Barlickiego UM w Lodzi ( Site 0256)

    Lodz, Łódź Voivodeship, 99-153, Poland

  • Sakarya Universitesi Egitim ve Arastirma Hastanesi ( Site 0323)

    Sakarya, 54290, Turkey (Türkiye)

  • Samsun Medical Park Hastanesi ( Site 0320)

    Samsun, 55200, Turkey (Türkiye)

  • Sarawak General Hospital ( Site 0064)

    Kuching, Sarawak, 93586, Malaysia

  • Scripps Cancer Center ( Site 0521)

    La Jolla, California, 92037, United States

  • Semmelweis Egyetem ( Site 0210)

    Budapest, 1083, Hungary

  • Sendai Kousei Hospital ( Site 0022)

    Sendai, Miyagi, 980-0873, Japan

  • Seoul National University Bundang Hospital ( Site 0075)

    Seongnam-si, Kyonggi-do, 13620, South Korea

  • Shanghai Chest Hospital ( Site 0112)

    Shanghai, Shanghai Municipality, 230000, China

  • Sheba Medical Center ( Site 0220)

    Ramat Gan, Tel Aviv, 5266202, Israel

  • Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0374)

    Valledupar, Cesar Department, 200001, Colombia

  • Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 0217)

    Kaposvár, 7400, Hungary

  • Soroka Medical Center ( Site 0222)

    Beersheba, 8457108, Israel

  • Sourasky Medical Center ( Site 0225)

    Tel Aviv, 6423906, Israel

  • St John of God Murdoch Medical Clinic ( Site 0001)

    Perth, Western Australia, 6150, Australia

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 0243)

    Krakow, Lesser Poland Voivodeship, 31-826, Poland

  • Szpital Uniwersytecki im. Karola Marcinkowskiego ( Site 0247)

    Zielona Góra, Lubusz Voivodeship, 65-046, Poland

  • Taipei Medical University Shuang Ho Hospital ( Site 0090)

    New Taipei City, 235, Taiwan

  • Taipei Veterans General Hospital ( Site 0089)

    Taipei, 112, Taiwan

  • The First Affiliated Hospital Zhejiang University ( Site 0106)

    Hangzhou, Zhejiang, 310003, China

  • The First Affiliated Hospital of Anhui Medical University ( Site 0113)

    Hefei, Anhui, 230088, China

  • The First Hospital of Jilin University ( Site 0110)

    Changchun, Jilin, 130021, China

  • The Prince Charles Hospital ( Site 0011)

    Chermside, Queensland, 4032, Australia

  • Toranomon Hospital ( Site 0016)

    Tokyo, 105-8470, Japan

  • Tudogyogyintezet Torokbalint ( Site 0205)

    Törökbálint, Pest County, 2045, Hungary

  • Ukranian Center of TomoTherapy ( Site 0344)

    Kropyvnytskiy, Kirovohrad Oblast, 25011, Ukraine

  • Ulsan University Hospital ( Site 0077)

    Ulsan, Ulsan-Kwangyokshi, 44033, South Korea

  • Universita Magna Grecia ( Site 0230)

    Catanzaro, 88100, Italy

  • University Malaya Medical Centre ( Site 0061)

    Kuala Lumpur, 59100, Malaysia

  • University of Kentucky School of Medicine & Hospitals ( Site 0517)

    Lexington, Kentucky, 40536, United States

  • University of Missouri Health Care ( Site 0555)

    Columbia, Missouri, 65212, United States

  • West China Hospital of Sichuan University ( Site 0117)

    Chengdu, Sichuan, 510115, China

  • William Osler Health System (Brampton Civic Hospital) ( Site 0402)

    Brampton, Ontario, L6R 3J7, Canada

  • Windsor Regional Cancer Program ( Site 0404)

    Windsor, Ontario, N8W 2X3, Canada

  • Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 0250)

    Przemyśl, Podkarpackie Voivodeship, 37-700, Poland

  • Wollongong Private Hospital ( Site 0005)

    Wollongong, New South Wales, 2500, Australia

  • Xiangya Hospital of Central South University ( Site 0115)

    Changsha, Hunan, 410008, China

  • Zhejiang Cancer Hospital ( Site 0116)

    Hangzhou, Zhejiang, 310022, China

  • Zhongshan Hospital Fudan University ( Site 0100)

    Shanghai, Shanghai Municipality, 200433, China

Conditions

Explore the condition pages connected to this study.