Major trial tests Four-Drug attack on deadly lung cancer
NCT ID NCT03829319
Summary
This large, completed Phase 3 trial tested whether adding a drug called lenvatinib to the standard first treatment (chemotherapy plus pembrolizumab) could better control advanced non-small cell lung cancer that had spread. It involved 761 adults and aimed to see if the four-drug combination helped people live longer and kept the cancer from worsening for a longer time compared to the standard three-drug treatment. The study also closely tracked side effects and quality of life.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Aberdeen Royal Infirmary ( Site 0288)
Aberdeen, Scotland, AB25 2ZN, United Kingdom
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Abington Hospital - Asplundh Cancer Center ( Site 0575)
Willow Grove, Pennsylvania, 19090, United States
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Ankara Sehir Hastanesi ( Site 0323)
Ankara, 06800, Turkey (Türkiye)
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Ankara Universitesi Tip Fakultesi. ( Site 0317)
Ankara, 06620, Turkey (Türkiye)
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Auckland City Hospital ( Site 0011)
Auckland, 1023, New Zealand
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Ballarat Health Services ( Site 0003)
Ballarat, Victoria, 3350, Australia
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Beijing Cancer Hospital ( Site 0120)
Beijing, Beijing Municipality, 100036, China
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Blacktown Hospital Western Sydney Local Health District ( Site 0008)
Blacktown, New South Wales, 2148, Australia
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Bradford Hill Centro de Investigaciones Clinicas ( Site 0387)
Santiago, Region M. de Santiago, 8420383, Chile
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Broome Oncology, LLC ( Site 0562)
Johnson City, New York, 13790, United States
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CEMAIC ( Site 0374)
Córdoba, X5008HHW, Argentina
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CEMIC ( Site 0370)
Buenos Aires, Buenos Aires F.D., C1431FWO, Argentina
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CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica ( Site 0372)
San Juan, J5402DIL, Argentina
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CHU de Quebec-Universite Laval-Hotel Dieu de Quebec ( Site 0403)
Québec, Quebec, G1R 2J6, Canada
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CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0412)
Montreal, Quebec, H3T 1M5, Canada
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CIUSSS de la Mauricie et du Centre du Quebec ( Site 0408)
Trois-Rivières, Quebec, G8Z 3R9, Canada
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Cairns Hospital ( Site 0002)
Cairns, Queensland, 4870, Australia
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Cambridge University Hospitals NHS Trust ( Site 0293)
Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
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Cancer Hospital Affiliated to Xinjiang Medical University ( Site 0110)
Urumuqi, Xinjiang, 830000, China
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Cancer Hospital Chinese Academy of Medical Science ( Site 0117)
Beijing, Beijing Municipality, 100021, China
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Central Clinical Hospital with outpatient Clinic ( Site 0262)
Moscow, Moscow, 121359, Russia
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Centre Paul Strauss ( Site 0144)
Strasbourg, Bas-Rhin, 67065, France
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Centre de Cancerologie du Grand Montpellier ( Site 0142)
Montpellier, Herault, 34070, France
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Centro Oncologico Antofagasta ( Site 0386)
Antofagasta, 1240000, Chile
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Centro de Investigacion y desarrollo Oncologico SpA - CIDO SpA ( Site 0380)
Temuco, Región de la Araucanía, 4810218, Chile
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Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 0367)
Berazategui, Buenos Aires, B1884BBF, Argentina
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Centrum Onkologii im.prof. F. Lukaszczyka w Bydgoszczy ( Site 0601)
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland
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Chris OBrien Lifehouse ( Site 0006)
Sydney, New South Wales, 2050, Australia
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Christie NHS Foundation Trust ( Site 0275)
Manchester, M20 4BX, United Kingdom
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Chungbuk National University Hospital ( Site 0062)
Cheongju-si, North Chungcheong, 28644, South Korea
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City Clinical Hospital 1 na. NI. Pirogov ( Site 0270)
Moscow, Moscow, 119049, Russia
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Clinica Universidad Catolica del Maule ( Site 0385)
Talca, Maule Region, 3465584, Chile
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Complejo Hospitalario Universitario A Coruna ( Site 0239)
A Coruña, La Coruna, 15006, Spain
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Complejo Hospitalario de Malaga ( Site 0238)
Málaga, 29010, Spain
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Cukurova Universitesi Tıp Fakultesi Balcalı Hastanesi ( Site 0314)
Adana, 01330, Turkey (Türkiye)
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Ege Universitesi Tip Fakultesi ( Site 0313)
Izmir, 35100, Turkey (Türkiye)
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El Camino Hospital Cancer Center ( Site 0529)
Mountain View, California, 94040, United States
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FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 0264)
Moscow, Moscow, 125367, Russia
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First Affiliated Hospital of The Third Military Medical University ( Site 0118)
Chongqing, Chongqing Municipality, 400038, China
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First Pavlov State Medical University of Saint Petersburg-Department of Oncology ( Site 0273)
Saint Petersburg, Sankt-Peterburg, 197022, Russia
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Fujian Provincial Cancer Hospital ( Site 0102)
Fuzhou, Fujian, 350014, China
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Fujita Health University Hospital ( Site 0016)
Toyoake, Aichi-ken, 470-1192, Japan
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Fundacion Arturo Lopez Perez FALP ( Site 0383)
Santiago, Region M. de Santiago, 7500921, Chile
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Good Samaritan Hospital Corvallis ( Site 0521)
Corvallis, Oregon, 97330, United States
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Guys and St Thomas NHS Foundation Trust ( Site 0280)
London, London, City of, SE1 9RT, United Kingdom
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Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0310)
Istanbul, 34722, Turkey (Türkiye)
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Hacettepe Universitesi Tıp Fakultesi ( Site 0316)
Ankara, 06100, Turkey (Türkiye)
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Hamato-Onkologie Hamburg Prof. Laack und Partner ( Site 0161)
Hamburg, 20251, Germany
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Henan Cancer Hospital ( Site 0112)
Zhengzhou, Henan, 450008, China
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Henry Ford Health System ( Site 0563)
Detroit, Michigan, 48202, United States
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Holy Cross Hospital ( Site 0512)
Fort Lauderdale, Florida, 33308, United States
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Holy Family Hospital ( Site 0228)
Nazareth, 1641101, Israel
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Hopital Cardiologique Louis Pradel ( Site 0141)
Bron, Auvergne-Rhône-Alpes, 69500, France
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Hopital Cite de la Sante de Laval ( Site 0400)
Laval, Quebec, H7M 3L9, Canada
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Hopital Cochin ( Site 0140)
Paris, 75014, France
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Hopital Foch ( Site 0145)
Suresnes, Hauts-de-Seine, 92151, France
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Hopital Laennec ( Site 0146)
Nantes, Loire-Atlantique, 44093, France
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Hopital Nord du Marseille ( Site 0147)
Marseille, Bouches-du-Rhone, 13015, France
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Hopital Robert Schuman ( Site 0143)
Vantoux, Moselle, 57070, France
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Hospital Aleman ( Site 0368)
Buenos Aires, C1118AAT, Argentina
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Hospital Clinico San Carlos ( Site 0235)
Madrid, 28040, Spain
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Hospital General Universitario Gregorio Maranon ( Site 0237)
Madrid, 28009, Spain
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Hospital General Universitario de Alicante ( Site 0240)
Alicante, 03010, Spain
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Hospital General Universitario de Valencia ( Site 0231)
Valencia, Valenciana, Comunitat, 46014, Spain
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Hospital Santa Creu i Sant Pau ( Site 0241)
Barcelona, 08025, Spain
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Hospital Universitario Insular de Gran Canaria ( Site 0244)
Las Palmas de Gran Canaria, Las Palmas, 35001, Spain
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Hospital Universitario La Fe ( Site 0233)
Valencia, Valenciana, Comunitat, 46026, Spain
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Hospital Universitario La Paz ( Site 0236)
Madrid, 28046, Spain
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Hospital Universitario Miguel Servet ( Site 0242)
Zaragoza, 50009, Spain
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Hubei Cancer Hospital ( Site 0122)
Wuhan, Hubei, 430079, China
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ICO L Hospitalet ( Site 0234)
L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Inonu Universitesi Medical Fakultesi ( Site 0318)
Malatya, 44280, Turkey (Türkiye)
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Instituto Medico Especializado Alexander Fleming ( Site 0369)
Buenos Aires, C1426ANZ, Argentina
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Instituto de Investigaciones Clinicas Mar del Plata ( Site 0371)
Mar del Plata, Buenos Aires, B7600FZO, Argentina
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Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0312)
Istanbul, 34098, Turkey (Türkiye)
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Jilin Cancer Hospital ( Site 0115)
Changchun, Jilin, 130103, China
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Juravinski Cancer Centre ( Site 0407)
Hamilton, Ontario, L8V 1C3, Canada
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Kanazawa University Hospital ( Site 0018)
Kanazawa, Ishikawa-ken, 920-8641, Japan
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Kansai Medical University Hospital ( Site 0022)
Hirakata, Osaka, 573-1191, Japan
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Kingston Health Sciences Centre ( Site 0414)
Kingston, Ontario, K7L 2V7, Canada
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Klinikum Esslingen GmbH ( Site 0164)
Esslingen am Neckar, Baden-Wurttemberg, 73730, Germany
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Krankenhaus Martha Maria Halle-Doelau ( Site 0166)
Halle, Saxony-Anhalt, 06120, Germany
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Krankenhaus Nordwest ( Site 0169)
Frankfurt am Main, Hesse, 60488, Germany
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L'hopital Nord-Ouest - Centre Hospitalier de Villefranche sur Saone ( Site 0149)
Villefranche-sur-Saône, Rhone, 69655, France
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Lakeridge Health ( Site 0406)
Oshawa, Ontario, L1G 2B9, Canada
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Leeds Teaching Hospital NHS Trust. St. James University Hospital ( Site 0276)
Leeds, LS9 7TF, United Kingdom
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Leicester Royal Infirmary ( Site 0284)
Leicester, LE1 5WW, United Kingdom
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Leningrad Regional Oncology Center ( Site 0271)
Saint Petersburg, Leningradskaya Oblast', 197758, Russia
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LungenClinic Grosshansdorf GmbH ( Site 0171)
Großhansdorf, Schleswig-Holstein, 22927, Germany
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MED-POLONIA Sp. z o.o. ( Site 0609)
Poznan, Greater Poland Voivodeship, 60-693, Poland
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Meir Medical Center ( Site 0221)
Kfar Saba, 4428164, Israel
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Mercy Health-Paducah Medical Oncology and Hematology ( Site 0570)
Paducah, Kentucky, 42003, United States
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Moncton Hospital - Horizon Health Network ( Site 0410)
Moncton, New Brunswick, E1C 6Z8, Canada
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Moscow Regional Oncological Dispensary ( Site 0274)
Balashikha, Moscow Oblast, 143900, Russia
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Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0603)
Warsaw, Masovian Voivodeship, 02-781, Poland
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National Cancer Center ( Site 0061)
Goyang-si, Kyonggi-do, 10408, South Korea
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National Cancer Center Hospital ( Site 0026)
Tokyo, 104-0045, Japan
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National Cancer Center Hospital East ( Site 0024)
Kashiwa, Chiba, 277-8577, Japan
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National Hospital Organization Nagoya Medical Center ( Site 0017)
Nagoya, Aichi-ken, 460-0001, Japan
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National Medical Research Radiology Centre ( Site 0260)
Moscow, Moscow, 125284, Russia
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Niigata Cancer Center Hospital ( Site 0019)
Niigata, 951-8566, Japan
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Nizhniy Novgorod Region Oncology Dispensary ( Site 0272)
Nizhny Novgorod, Nizhny Novgorod Oblast, 603081, Russia
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North Middlesex University Hospital NHS Trust ( Site 0291)
London, London, City of, N18 1QX, United Kingdom
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Nottingham City Hospital Campus ( Site 0287)
Nottingham, NG5 1PB, United Kingdom
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Omsk Clinical Oncology Dispensary ( Site 0267)
Omsk, Omsk Oblast, 644013, Russia
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Oncocentro ( Site 0384)
Viña del Mar, Región de Valparaíso, 2520598, Chile
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OrlandiOncologia ( Site 0381)
Santiago, Region M. de Santiago, 7500713, Chile
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Osaka Habikino Medical Center ( Site 0020)
Habikino, Osaka, 583-8588, Japan
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Parkland Health & Hospital System ( Site 0576)
Dallas, Texas, 75235, United States
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Peking Union Medical College Hospital ( Site 0108)
Beijing, Beijing Municipality, 100006, China
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Pius Hospital Oldenburg ( Site 0170)
Oldenburg, Lower Saxony, 26121, Germany
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Pleszewskie Centrum Medyczne w Pleszewie Sp. z o.o. ( Site 0615)
Pleszew, Greater Poland Voivodeship, 63-300, Poland
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Pontificia Universidad Catolica de Chile ( Site 0382)
Santiago, Region M. de Santiago, 8330032, Chile
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Port Macquarie Base Hospital ( Site 0001)
Port Macquarie, New South Wales, 2444, Australia
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Rabin Medical Center ( Site 0224)
Petah Tikva, 4941492, Israel
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Rambam Medical Center ( Site 0223)
Haifa, 3109601, Israel
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SAHI Republican Clinical Oncological Dispensary of the MoH of RT ( Site 0261)
Kazan', Tatarstan, Respublika, 420029, Russia
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Saint Lukes Cancer Institute ( Site 0541)
Kansas City, Missouri, 64111, United States
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Sanatorio Parque ( Site 0365)
Rosario, Santa Fe Province, S2000DSV, Argentina
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Sanford Health Roger Maris Cancer Center ( Site 0533)
Fargo, North Dakota, 58122, United States
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Sault Area Hospital ( Site 0413)
Sault Ste. Marie, Ontario, P6B 0A8, Canada
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Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0269)
Saint Petersburg, Sankt-Peterburg, 197758, Russia
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Severance Hospital Yonsei University Health System ( Site 0063)
Seoul, 03722, South Korea
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Shaare Zedek Medical Center-Oncology ( Site 0229)
Jerusalem, 9013102, Israel
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Shamir Medical Center-Assaf Harofeh ( Site 0227)
Ẕerifin, 70300, Israel
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Shanghai Pulmonary Hospital ( Site 0101)
Shanghai, Shanghai Municipality, 200443, China
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Sheba Medical Center ( Site 0220)
Ramat Gan, 5262000, Israel
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Soroka Medical Center ( Site 0222)
Beersheba, 8410101, Israel
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Sourasky Medical Center ( Site 0225)
Tel Aviv, 6423906, Israel
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Southern Medical University Nanfang Hospital ( Site 0121)
Guangzhou, Guangdong, 510515, China
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St Georges University Hospitals NHS Foundation Trust. ( Site 0292)
London, London, City of, SW17 0QT, United Kingdom
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Stephenson Cancer Center ( Site 0504)
Oklahoma City, Oklahoma, 73104, United States
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Szpital Wojewodzki im. Mikolaja Kopernika ( Site 0602)
Koszalin, West Pomeranian Voivodeship, 75-581, Poland
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Tauranga Hospital ( Site 0004)
Tauranga, Bay of Plenty, 3112, New Zealand
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The Cancer Institute Hospital of JFCR ( Site 0021)
Tokyo, 135-8550, Japan
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The Catholic University of Korea St. Vincent s Hospital ( Site 0064)
Gyeonggi-do, Kyonggi-do, 16247, South Korea
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The Clatterbridge Cancer Centre NHS Foundation Trust ( Site 0286)
Metropolitan Borough of Wirral, CH63 4JY, United Kingdom
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The First Affiliated Hospital Zhejiang University ( Site 0109)
Hangzhou, Zhejiang, 310003, China
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The First Affiliated Hospital of Wenzhou Medical University ( Site 0124)
Wenzhou, Zhejiang, 325000, China
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The Prince Charles Hospital ( Site 0010)
Chermside, Queensland, 4032, Australia
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The Second Hospital Affiliated to AMU ( Site 0119)
Chongqing, Chongqing Municipality, 400037, China
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The Third Affiliated Hospital of Harbin Medical University ( Site 0100)
Harbin, Heilongjiang, 150081, China
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Thomas Jefferson University Hospital ( Site 0548)
Philadelphia, Pennsylvania, 19107, United States
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Tianjin Medical University Cancer Institute & Hospital ( Site 0111)
Tianjin, Tianjin Municipality, 300060, China
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Tokyo Metropolitan Komagome Hospital ( Site 0015)
Tokyo, 113-8677, Japan
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UT Southwestern Medical Center ( Site 0558)
Dallas, Texas, 75390, United States
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Uniklinik RWTH Aachen ( Site 0160)
Aachen, North Rhine-Westphalia, 52074, Germany
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Universitaetsklinikum des Saarlandes ( Site 0165)
Homburg, Saarland, 66421, Germany
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Utah Cancer Specialists ( Site 0523)
Salt Lake City, Utah, 84106, United States
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Wakayama Medical University Hospital ( Site 0025)
Wakayama, 641-8510, Japan
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West Cancer Center - East Campus ( Site 0544)
Germantown, Tennessee, 38138, United States
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West Virginia University ( Site 0526)
Morgantown, West Virginia, 26506, United States
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Westmead Hospital ( Site 0009)
Sydney, New South Wales, 2145, Australia
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Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii ( Site 0613)
Lodz, Łódź Voivodeship, 93-513, Poland
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Wuhan Union Hospital Cancer Center-Cancer Center ( Site 0123)
Wuhan, Hubei, 430022, China
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Yale University ( Site 0519)
New Haven, Connecticut, 06520-8028, United States
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Zhejiang Cancer Hospital ( Site 0113)
Hangzhou, Zhejiang, 310022, China
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Zhongshan Hospital Fudan University ( Site 0103)
Shanghai, Shanghai Municipality, 200032, China
Conditions
Explore the condition pages connected to this study.