New drug duo targets tough lung cancer mutation

NCT ID NCT05054725

Completed Disease control Sponsor: Revolution Medicines, Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested whether combining two drugs, sotorasib and RMC-4630, could help control advanced non-small cell lung cancer with a specific genetic change called KRAS G12C. It involved 47 adults whose cancer had worsened despite trying standard treatments. The main goal was to see if the drug combination could shrink tumors and for how long.

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Contacts and locations

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Locations

APHM Hopital Nord, Service d'Oncologie Multidisciplinaire et innovations therapeutics

Marseille, 13015, France
American Oncology Partners of Maryland, PA

Bethesda, Maryland, 20817, United States
Asan Medical Center

Seoul, 05505, South Korea
Asklepios Fachkliniken Munchen

Gauting, Bavaria, 82131, Germany
Azienda Ospedaliera dei Colli

Naples, Campania, 80131, Italy
Azienda Sanitaria Ospedaliera S Luigi Gonzaga

Orbassano, Piedmont, 10043, Italy
BRCR Medical Center Inc.

Plantation, Florida, 33322, United States
Bethanien Hospital Moers

Moers, North Rhine-Westphalia, 47441, Germany
Blacktown Hospital

Blacktown, 2148, Australia
CHRISTUS St. Michael-Colom and Carney Clinic P.A

Texarkana, Texas, 75503, United States
Cancer Specialists of North Florida

Saint Augustine, Florida, 32086, United States
Charite Benjamin Franklin Comprehensive Cancer center

Berlin, 12200, Germany
Charleston Oncology

Charleston, South Carolina, 29414, United States
Chungbuk National University Hospital

Cheongju-si, 28644, South Korea
Clinica Universidad de Navarra

Pamplona, Navarre, 31008, Spain
Clinica Universidad de Navarra

Madrid, 28027, Spain
Clinical Research Alliance, Inc.

New York, New York, 10021, United States
Complejo Hospitalario Universitario A Coruña

A Coruña, Galicia, 15006, Spain
Comprehensive Cancer Center Mainfranken, University Wuerzburg

Homburg, Saarland, 66421, Germany
Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89169, United States
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
E-DA Hospital

Kaohsiung City, 824, Taiwan
Evangelische Lung Clinic

Berlin, 13125, Germany
Florida Cancer Specialists

Fort Myers, Florida, 33901, United States
GenHarp Clinical Solutions

Evergreen Park, Illinois, 60805, United States
Goulburn Valley Health

Shepparton, 3630, Australia
Hamato-Onkologie Hamburg

Hamburg, 20251, Germany
Hematology Oncology Clinic

Baton Rouge, Louisiana, 70809, United States
Hospital Clinic de Barcelona

Barcelona, Catalonia, 08036, Spain
Hospital Larrey Universite Paul Sabatier

Toulouse, 31059, France
Hospital Universitario Virgen Macarena

Seville, Andalusia, 41009, Spain
Hospital Universitario y Politecnico La Fe

Valencia, 46026, Spain
Istituto Europeo Di Oncologia

Milan, 20141, Italy
Kaohsiung Medical University Chung Ho Memorial Hospital

Kaohsiung City, 807, Taiwan
Klinikum Esslingen GmbH

Esslingen am Neckar, Baden-Wurttemberg, 73730, Germany
Lung Cancer Center, University of Saarland

Homburg, Saarland, 66421, Germany
Lungenklinik Hemer

Hemer, North Rhine-Westphalia, 58675, Germany
Maryland Oncology Hematology, P.A.

Columbia, Maryland, 21044, United States
Minnesota Oncology Hematology, P.A.

Minneapolis, Minnesota, 55404, United States
National Cheng Kung University Hospital

Tainan, 704, Taiwan
National Taiwan University Hospital

Taipei, 10002, Taiwan
Nebraska Cancer Specialists

Omaha, Nebraska, 68130, United States
New England Cancer Specialists

Scarborough, Maine, 04074, United States
New Jersey Center for Cancer Research

Brick, New Jersey, 08724, United States
Northwest Cancer specialists, P.C.

Vancouver, Washington, 98684, United States
POIS Sachsen GmbH

Leipzig, Saxony, 04347, Germany
Roswell Park cancer Institute

Buffalo, New York, 14263, United States
Samsung Medical Center

Seoul, 06351, South Korea
Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States
Seoul National University Hospital

Seoul, 03080, South Korea
South West Oncology

Warrnambool, Victoria, 3280, Australia
Taichung Veterans General Hospital

Taichung, 40705, Taiwan
Tennessee Oncology

Chattanooga, Tennessee, 37404, United States
The Christie NHS Foundation Trust

Manchester, Greater Manchester, M20 4BX, United Kingdom
The Royal Marsden NHS Foundation Trust

Sutton, Surrey, SM2 5PT, United Kingdom
University of New Mexico Comprehensive Cancer Center

Albuquerque, New Mexico, 87131, United States
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates

Norfolk, Virginia, 23502, United States
William Osler Health System

Mississauga, Ontario, L5N 5M8, Canada
Zangmeister Cancer Center

Columbus, Ohio, 43219, United States

Conditions

Explore the condition pages connected to this study.

NON-SMALL CELL LUNG CANCER