New drug duo challenges standard in major lung cancer trial

NCT ID NCT04487080

Summary

This large, late-stage study is comparing a new two-drug combination (amivantamab + lazertinib) against the current standard single-drug treatment (osimertinib) for people newly diagnosed with a specific type of advanced lung cancer. It aims to see if the combination can better control the cancer and help patients live longer without their disease getting worse. The trial enrolled over 1,000 participants who have not received prior treatment for their advanced cancer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Adana City Hospital

    Adana, 01060, Turkey (Türkiye)

  • Algemeen Ziekenhuis Delta

    Roeselare, 8800, Belgium

  • Ankara Bilkent City Hospital

    Ankara, 6800, Turkey (Türkiye)

  • Aou San Luigi Gonzaga

    Orbassano, 10043, Italy

  • Arizona Oncology Associates, PC - HAL

    Goodyear, Arizona, 85395, United States

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Asklepios Klinik Gauting GmbH - Asklepios Fachkliniken Munchen-Gauting

    Gauting, 82131, Germany

  • Astera Cancer Care

    East Brunswick, New Jersey, 08816, United States

  • Austin Hospital

    Heidelberg, 3084, Australia

  • Azienda Ospedaliero Univ. Policlinico Gaspare Rodolico

    Catania, 95123, Italy

  • Basavatarakam Indo-American Hospital

    Hyderabad, 500034, India

  • Bashkir State Medical University

    Ufa, 450083, Russia

  • Başkent University Medical Faculty Adana Application and Research Center

    Adana, 01250, Turkey (Türkiye)

  • Beacon Hospital Sdn Bhd

    Petaling Jaya, 46050, Malaysia

  • Beijing Cancer Hospital

    Beijing, 100142, China

  • Beijing Chest hospital, Capital medical university

    Beijing, 101199, China

  • Beijing Friendship Hospital Capital Medical University

    Beijing, 100050, China

  • CHU Bordeaux

    Pessac, 33604, France

  • CHU Bretonneau

    Tours, 37000, France

  • CHU Nantes

    Sain-Herblain, 44800, France

  • CHU de Grenoble Hopital Albert Michallon

    La Tronche, 38700, France

  • CHU de Limoges

    Limoges, 87000, France

  • CIMOVA, Morals Vargas Centro de Investigación SC

    León, 37000, Mexico

  • Cabrini Medical Centre

    Malvern, 3144, Australia

  • Cancer Hospital of Xinjiang Medical University

    Ürümqi, 830000, China

  • Cancer Specialists of North Florida

    Jacksonville, Florida, 32256, United States

  • Centro Oncologico Riojano Integral (Cori)

    La Rioja, F5300COE, Argentina

  • Centro Oncológico Korben

    Buenos Aires, C1426AGE, Argentina

  • Centrum Onkologii im Prof F Lukaszczyka

    Bydgoszcz, 85 796, Poland

  • Cetus Oncologia

    Belo Horizonte, 30110-022, Brazil

  • Chaim Sheba Medical Center

    Ramat Gan, 5262100, Israel

  • Chang Gung Medical Foundation

    Kaohsiung City, 833, Taiwan

  • Chelsea And Westminster Hospital

    London, SW10 9NH, United Kingdom

  • Chiang Mai University

    Chiang Mai, 50200, Thailand

  • China Medical University Hospital

    Taichung, 40447, Taiwan

  • Chinese PLA General Hospital

    Beijing, 100853, China

  • Christie NHS Foundation Trust

    Manchester, M20 4BX, United Kingdom

  • Chung Shan Medical University Hospital

    Taichung, 402, Taiwan

  • Chungbuk National University Hospital

    Cheongju-si, 28644, South Korea

  • City Clinical Hospital #1

    Nal'chik, 360000, Russia

  • City of Hope Long Beach Elm

    Long Beach, California, 90813, United States

  • Clinica Univ. de Navarra

    Pamplona, 31008, Spain

  • Clinique Saint Pierre

    Ottignies, 1340, Belgium

  • Cliniques Universitaires Saint Luc

    Brussels, 1200, Belgium

  • Clínica Viedma

    Viedma, R8500ACE, Argentina

  • Current medical technologies

    Saint Petersburg, 190121, Russia

  • Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4

    Dnipro, 49102, Ukraine

  • E-DA Hospital

    Kaohsiung City, 824, Taiwan

  • East Jefferson General Hospital

    Metairie, Louisiana, 70006, United States

  • Edinburgh Cancer Centre Western General

    Edinburgh, EH4 2XU, United Kingdom

  • Ehime University Hospital

    Toon-shi, 791-0295, Japan

  • Fejer Varmegyei Szent Gyorgy Egyetemi Oktatokorhaz

    Székesfehérvár, 8000, Hungary

  • Flinders Medical Centre

    Bedford Park, 5042, Australia

  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, 20133, Italy

  • Fudan University Shanghai Cancer Center

    Shanghai, 200032, China

  • Fundacao Antonio Prudente A C Camargo Cancer Center

    São Paulo, 01509 900, Brazil

  • Fundacao Faculdade de Medicina Instituto do Cancer do Estado de Sao Paulo

    São Paulo, 01246 000, Brazil

  • Fundacao Pio XII

    Barretos, 14784-400, Brazil

  • Gazi University Hospital

    Ankara, 6560, Turkey (Türkiye)

  • Grand Hopital De Charleroi Site Les Viviers

    Charleroi, 6060, Belgium

  • HCG Manavta Cancer Centre

    Nashik, 422002, India

  • HIA Begin

    Saint-Mandé, 94163, France

  • Hadassah Medical Center

    Jerusalem, 9112001, Israel

  • Harbin medical university cancer hospital

    Harbin, 150000, China

  • Health Pharma Professional Research

    México, 03100, Mexico

  • Helios Klinikum Emil von Behring GmbH

    Berlin, 14165, Germany

  • Henan Cancer Hospital

    Zhengzhou, 450008, China

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Hopital Nord

    Marseille, 13915, France

  • Hopital Tenon

    Paris, 75970, France

  • Hosp Regional Univ de Malaga

    Málaga, 29011, Spain

  • Hosp Univ A Coruna

    A Coruña, 15006, Spain

  • Hosp Univ Vall D Hebron

    Barcelona, 08035, Spain

  • Hosp. Clinico Univ. Lozano Blesa

    Zaragoza, 50009, Spain

  • Hosp. Cuf Porto

    Porto, 4100 180, Portugal

  • Hosp. Gral. Univ. Gregorio Maranon

    Madrid, 28007, Spain

  • Hosp. Gral. Univ. Valencia

    Valencia, 46014, Spain

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041, Spain

  • Hosp. Univ. La Paz

    Madrid, 28046, Spain

  • Hosp. Univ. Pta. de Hierro Majadahonda

    Majadahonda, 28222, Spain

  • Hosp. Univ. Quiron Dexeus

    Barcelona, 08028, Spain

  • Hosp. Univ. de Burgos

    Burgos, 09003, Spain

  • Hosp. Virgen Del Rocio

    Seville, 41013, Spain

  • Hosp. de La Santa Creu I Sant Pau

    Barcelona, 08025, Spain

  • Hospices Civils de Lyon HCL

    Bron, 69500, France

  • Hospital Civil de Guadalajara Fray Antonio Alcalde

    Guadalajara, 44280, Mexico

  • Hospital Evangélico de Cachoeiro de Itapemirim

    Vitória, 29308-014, Brazil

  • Hospital Kuala Lumpur

    Kuala Lumpur, 50586, Malaysia

  • Hospital Privado Centro Medico de Cordoba

    Córdoba, X5016KEH, Argentina

  • Hospital Pulau Pinang

    George Town, 10990, Malaysia

  • Hospital Sultan Ismail

    Johor Bahru, 81100, Malaysia

  • Hospital Tengku Ampuan Afzan

    Kuantan, 25100, Malaysia

  • Huizhou Municipal Central Hospital

    Huizhou, 516001, China

  • Hunan Cancer hospital

    Changsha, 410013, China

  • IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado

    Sorocaba, 18030-075, Brazil

  • IRCCS Ospedale San Raffaele

    Milan, 20132, Italy

  • Inje University Haeundae Paik Hospital

    Busan, 48108, South Korea

  • Inst. Cat. D'Oncologia-Badalona

    Badalona, 08916, Spain

  • Institut Bergonie

    Bordeaux, 33000, France

  • Institut Català D'Oncologia Girona

    Girona, 17007, Spain

  • Institut Curie

    Paris, 75005, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institute Coeur Poumon

    Lille, 59000, France

  • Instituto Alexander Fleming

    Buenos Aires, C1428ANZ, Argentina

  • Instituto D Or de Pesquisa e Ensino IDOR

    Rio de Janeiro, 22281 100, Brazil

  • Instituto Nacional de Cancerologia

    México, 14080, Mexico

  • Instituto Portugues de Oncologia

    Porto, 4200-072, Portugal

  • Irccs Gemelli

    Roma, 00168, Italy

  • Irkutsk Regional Oncology Dispensary

    Irkutsk, 664035, Russia

  • Irmandade Santa Casa de Misericordia de Porto Alegre

    Porto Alegre, 90020-090, Brazil

  • Istanbul Universitesi Cerrahpasa Tip Fakultesi Ic Hastaliklari Anabilim Dali Medikal Onkoloji Bd

    Istanbul, 34098, Turkey (Türkiye)

  • Istituto Clinico Humanitas

    Rozzano, 20089, Italy

  • Istituto Europeo di Oncologia

    Milan, 20141, Italy

  • Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

    Meldola, 47014, Italy

  • Jeroen Bosch Ziekenhuis

    's-Hertogenbosch, 5223 GZ, Netherlands

  • Jilin cancer hospital

    Changchun, 130000, China

  • Juntendo University Hospital

    Bunkyō City, 113 8431, Japan

  • Juravinski Cancer Centre

    Hamilton, Ontario, L8V 5C2, Canada

  • Kanazawa University Hospital

    Kanazawa, 920 8641, Japan

  • Kangbuk Samsung Hospital

    Seoul, 03181, South Korea

  • Kansai Medical University Hospital

    Hirakata, 573 1191, Japan

  • Kaohsiung Medical University Chung Ho Memorial Hospital

    Kaohsiung City, 807, Taiwan

  • Kindai University Hospital

    Osaka Sayama Shi, 589 8511, Japan

  • Kliniken der Stadt Koeln gGmbH

    Cologne, 51109, Germany

  • Korea University Guro Hospital

    Seoul, 8308, South Korea

  • Krasnoyarsk Regional Oncology Dispensary

    Krasnoyarsk, 660133, Russia

  • Kurume University Hospital

    Kurume, 830-0011, Japan

  • Leningrad Regional Oncology Dispensary

    Kuzmolovsky, 188663, Russia

  • Liga Norte Riograndense Contra O Cancer

    Natal, 59062 000, Brazil

  • MCK

    Moscow, 115533, Russia

  • Markusovszky Egyetemi Oktatokorhaz

    Szombathely, 9700, Hungary

  • Maryland Oncology Hematology, PA

    Columbia, Maryland, 21044, United States

  • Matsusaka Municipal Hospital

    Matsusaka, 515-8544, Japan

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • McGill University Health Centre

    Montreal, Quebec, H4A 3J1, Canada

  • Medical Center 'Ok Clinic' of LLC 'International Institute of Clinical Studies'

    Kyiv, 02091, Ukraine

  • Medical Point

    Izmir, 35575, Turkey (Türkiye)

  • Medipol Mega University Hospital

    Istanbul, 34214, Turkey (Türkiye)

  • Meir Medical Center

    Kfar Saba, 44281, Israel

  • Mexico Centre for Clinical Research, S.A. de C.V.

    Mexico City, 03100, Mexico

  • Ministerio da Saude Instituto Nacional do Cancer

    Rio de Janeiro, 20231 050, Brazil

  • Minnesota Oncology Hematology P A

    Edina, Minnesota, 55435, United States

  • Moscow City Oncology Hospital № 62

    Krasnogorsk, 143423, Russia

  • Municipal Oncology Centre of Uzhgorod Central Municipal Clinical Hospitlal

    Uzhhorod, 88000, Ukraine

  • Municipal non-profit enterprise 'Regional Center of Oncology'

    Kharkiv, 61070, Ukraine

  • Mátrai Gyógyintézet-Bronchológia

    Gyöngyös, 3233, Hungary

  • Médica Sur

    Mexico City, 14050, Mexico

  • N.N. Petrov Research Institute Of Oncology

    Saint Petersburg, 197758, Russia

  • Nantong Tumor Hospital

    Nantong, 226300, China

  • Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy

    Warsaw, 02-781, Poland

  • National Cancer Center Hospital

    Chūōku, 104 0045, Japan

  • National Cancer Center Hospital East

    Kashiwa, 277 8577, Japan

  • National Cancer Institute

    Kyiv, 03022, Ukraine

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Hospital Organization Himeji Medical Center

    Himeji, 670-8520, Japan

  • National Hospital Organization Iwakuni Clinical Center

    Yamaguchi, 740-8510, Japan

  • National Hospital Organization Kyushu Medical Center

    Fukuoka, 810-8563, Japan

  • National Hospital Organization Osaka Toneyama Medical Center

    Toyonaka-shi, 560-8552, Japan

  • National Hospital Organization Shibukawa Medical Center

    Shibukawa, 377-0280, Japan

  • National Hospital Organization Tokyo Medical Center

    Tokyo, 152 8902, Japan

  • National Hospital Organization Yamaguchi Ube Medical Center

    Yamaguchi, 755-0241, Japan

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • Necmettin Erbakan University Meram Medical Faculty

    Konya, 42080, Turkey (Türkiye)

  • Niigata Cancer Center Hospital

    Niigata, 951-8566, Japan

  • Nizhny Novgorod Regional Oncological Dispensary

    Nizhny Novgorod, 603000, Russia

  • Noble Hospital Pvt Ltd

    Pune, 411013, India

  • Nottingham University Hospitals NHS Trust

    Nottingham, NG5 1PB, United Kingdom

  • Núcleo de Pesquisa São Camilo

    São Paulo, 04014-002, Brazil

  • Okayama University Hospital

    Okayama, 700 8558, Japan

  • Omsk Clinical Oncology Dispensary

    Omsk, 664013, Russia

  • Oncoclinicas Rio de Janeiro S A

    Rio de Janeiro, 22 250 905, Brazil

  • Oncologia Integral Satelite

    Naucalpan, 53100, Mexico

  • Oncology Consultants Texas

    Houston, Texas, 77030, United States

  • Oncology Medical Clinics AV Medical group

    Saint Petersburg, 196006, Russia

  • Oncosite - Centro de Pesquisa Clínica em Oncologia Ltda

    Ijuí, 98700-000, Brazil

  • Onkologische Schwerpunktpraxis

    Heilbronn, 74072, Germany

  • Orszagos Koranyi Tbc es Pulmonologiai Intezet

    Budapest, H-1529, Hungary

  • Ospedale Monaldi

    Napoli, 80100, Italy

  • Ospedale S. Maria Delle Croci

    Ravenna, 48121, Italy

  • Ospedale San Giuseppe Moscati di Avellino

    Avellino, 83100, Italy

  • POIS Leipzig GbR

    Leipzig, 04357, Germany

  • Pan American Center for Oncology Trials LLC

    Rio Piedras, 00935, Puerto Rico

  • Phramongkutklao Hospital and Medical College

    Bangkok, 10400, Thailand

  • Pius-Hospital Oldenburg

    Oldenburg, 26121, Germany

  • Princess Alexandra Hospital

    Woolloongabba, 4102, Australia

  • Private Specialist Hospitals - MedPolonia

    Poznan, 60-693, Poland

  • Rabin Medical Center

    Petah Tikva, 49100, Israel

  • Rambam Health Corporation

    Haifa, 3109601, Israel

  • Rijnstate Ziekenhuis

    Arnhem, 6815 AD, Netherlands

  • Robert-Bosch-Krankenhaus - Klinik Schillerhoehe

    Stuttgart, 70376, Germany

  • Rocky Mountain Cancer Centers

    Lone Tree, Colorado, 80124, United States

  • Ruijin Hospital Shanghai Jiao Tong University

    Shanghai, 200025, China

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • San Gerardo Hospital

    Monza, 20052, Italy

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • Second Affiliated Hospital, School of Medicine, Zhejiang University

    Hangzhou, 310009, China

  • Seoul National University Bundang Hospital

    Seongnam-si, 13620, South Korea

  • Severance Hospital Yonsei University Health System

    Seoul, 03722, South Korea

  • Shanghai Chest Hospital

    Shanghai, 200030, China

  • Shanghai East Hospital

    Shanghai, 200123, China

  • Shengjing Hospital Of China Medical University

    Shenyang, 110022, China

  • Sichuan Cancer Hospital

    Chengdu, 610041, China

  • Sir Charles Gairdner Hospital

    Nedlands, 6009, Australia

  • Sir Run Run Shaw Hospital Zhejiang University School of Medicine

    Hangzhou, 310016, China

  • Siriraj Hospital

    Bangkok, 10700, Thailand

  • Songklanagarind Hospital, Prince of Songkla University

    Songkhla, 90110, Thailand

  • Southern Medical Day Care Centre

    Wollongong, 2500, Australia

  • Southwest Hospital

    Chongqing, 400038, China

  • St John of God Hospital Murdoch

    Murdoch, 6150, Australia

  • Städtisches Krankenhaus Martha-Maria Halle-Dölau gGmbH

    Halle, 06120, Germany

  • Sun Yat-Sen Memorial Hospital Sun Yat-sen University

    Guangzhou, 510120, China

  • Szpitale Pomorskie Sp z o o

    Gdynia, 81 519, Poland

  • T C Saglik Bakanlıgi Goztepe Prof Dr Suleyman Yalcın Sehir Hastanesi

    Istanbul, 34722, Turkey (Türkiye)

  • Taipei Medical University Shuang Ho Hospital

    New Taipei City, 23561, Taiwan

  • Taizhou Hospital of Zhejiang Province

    Linhai, 317000, China

  • Tambov Regional Oncology Clinical Dispansary

    Tambov, 392013, Russia

  • Tata Medical Center

    Kolkata, 700160, India

  • Tata Memorial Hospital

    Mumbai, 400012, India

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 6423906, Israel

  • Texas Oncology P A

    Austin, Texas, 78745, United States

  • The Cancer Institute Hospital of JFCR

    Tokyo, 135 8550, Japan

  • The Catholic University of Korea Seoul St Mary s Hospital

    Seoul, 06591, South Korea

  • The First Affiliated Hospital Sun Yat sen University

    Guangzhou, 510080, China

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, 325000, China

  • The First Affiliated Hospital of Xian Jiaotong University

    Xi'an, 710061, China

  • The First People's Hospital Of Changzhou

    Changzhou, 213003, China

  • The Ottawa Hospital Cancer Centre

    Ottawa, Ontario, K1H 8L6, Canada

  • The Royal Marsden NHS Trust

    London, SW3 6JJ, United Kingdom

  • The Royal Marsden NHS Trust

    Sutton, SM2 5PT, United Kingdom

  • The Second Affiliated Hospital of Zhejiang University College of Medicine

    Hangzhou, 310009, China

  • Thoraxklinik am Universitatsklinikum Heidelberg

    Heidelberg, 69126, Germany

  • Tianjin Medical University General Hospital

    Tianjin, 300052, China

  • Tomsk Cancer Research Institute

    Tomsk, 634050, Russia

  • TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology

    Wuhan, 430030, China

  • Trakya University Medical Faculty

    Edirne, 22030, Turkey (Türkiye)

  • Tudogyogyintezet Torokbalint

    Törökbálint, 2045, Hungary

  • UCL Cancer Institute

    London, NW1 2PG, United Kingdom

  • UMC Radboud

    Nijmegen, 6525AG, Netherlands

  • UPCO Unidade de Pesquisa Clinica em Oncologia

    Pelotas, 96020 080, Brazil

  • UZ Leuven

    Leuven, 3000, Belgium

  • Uls Santa Maria - Hosp. Pulido Valente

    Lisbon, 1769-001, Portugal

  • Uls Santo Antonio - Hosp. Santo Antonio

    Porto, 4099-001, Portugal

  • Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS

    Porto Alegre, 90610-000, Brazil

  • Universitaetsklinikum Essen

    Essen, 45147, Germany

  • University Cancer And Blood Center LLC

    Athens, Georgia, 30607, United States

  • University Malaya Medical Centre

    Kuala Lumpur, 59100, Malaysia

  • University of California Irvine

    Orange, California, 92868, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15232, United States

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80 214, Poland

  • Veszprém Megyei Tudőgyógyintézet

    Farkasgyepü, 8582, Hungary

  • Virginia Cancer Specialists

    Fairfax, Virginia, 22031, United States

  • Wakayama Medical University Hospital

    Wakayama, 641 8510, Japan

  • Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie

    Olsztyn, 10-357, Poland

  • Washington University School Of Medicine

    St Louis, Missouri, 63110, United States

  • West China Hospital Sichuan University

    Chengdu, 610041, China

  • Westmead Hospital

    Westmead, 2145, Australia

  • Willamette Valley Cancer Institute and Research Center

    Eugene, Oregon, 97401, United States

  • William Osler Health System

    Brampton, Ontario, L6R 3J7, Canada

  • Yantai Yuhuangding Hospital

    Yantai, 264000, China

  • Yaroslavl Regional Clinical Oncology Hospital

    Yaroslavl, 150054, Russia

  • Ynova Pesquisa Clinica

    Florianópolis, 88020-210, Brazil

  • Yuma Regional Medical Center

    Yuma, Arizona, 85364, United States

  • Zentralklinik Bad Berka GmbH

    Bad Berka, 99437, Germany

  • Zhejiang Cancer Hospital

    Hangzhou, 310022, China

  • Ziekenhuis St Jansdal

    Harderwijk, 3844 DG, Netherlands

  • i Can Oncology Center

    Monterrey, 64710, Mexico

Conditions

Explore the condition pages connected to this study.