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New hope for untreated lung cancer patients in combination therapy trial

NCT ID NCT04165083

Completed Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding new experimental drugs to an existing immunotherapy (pembrolizumab) could better control advanced non-small cell lung cancer in patients who had not yet received any treatment for their metastatic disease. It involved 102 participants whose cancer tested positive for a specific marker (PD-L1). The main goal was to see if these combinations could shrink tumors and delay cancer progression while monitoring safety.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Abramson Cancer Center of the University of Pennsylvania ( Site 0010)

    Philadelphia, Pennsylvania, 19104, United States

  • Azienda Ospedaliera Universitaria Careggi ( Site 0173)

    Florence, Firenze, 50134, Italy

  • Banner MD Anderson Cancer Center ( Site 0001)

    Gilbert, Arizona, 85234, United States

  • Chaim Sheba Medical Center ( Site 0070)

    Ramat Gan, 5262000, Israel

  • City of Hope ( Site 0014)

    Duarte, California, 91010, United States

  • Cleveland Clinic Main ( Site 0006)

    Cleveland, Ohio, 44195, United States

  • Dana Farber Cancer Institute ( Site 0002)

    Boston, Massachusetts, 02215, United States

  • Dartmouth Hitchcock Medical Center ( Site 0016)

    Lebanon, New Hampshire, 03766, United States

  • Georgetown University ( Site 0036)

    Washington D.C., District of Columbia, 20007, United States

  • Hospital Universitario Quiron Madrid ( Site 0091)

    Madrid, 28223, Spain

  • ICO L Hospitalet ( Site 0090)

    L'Hospitalet de Llobregat, Barcelona, 08907, Spain

  • IRCCS Ospedale San Raffaele ( Site 0171)

    Milan, 20132, Italy

  • John Theurer Cancer Center at Hackensack University Medical Center ( Site 0037)

    Hackensack, New Jersey, 07601, United States

  • Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 0061)

    Szolnok, Jász-Nagykun-Szolnok, 5004, Hungary

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0034)

    New York, New York, 10016, United States

  • Massachusetts General Hospital ( Site 0003)

    Boston, Massachusetts, 02114, United States

  • MedStar Franklin Square Medical Center ( Site 0033)

    Baltimore, Maryland, 21237, United States

  • Meir Medical Center ( Site 0071)

    Kfar Saba, 4428132, Israel

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 0151)

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • Ohio State University Comprehensive Cancer Center ( Site 0015)

    Columbus, Ohio, 43210, United States

  • Oncology Hematology West, PC DBA Nebraska Cancer Specialists ( Site 0031)

    Omaha, Nebraska, 68130, United States

  • Orszagos Koranyi Pulmonologiai Intezet ( Site 0060)

    Budapest, 1121, Hungary

  • Petz Aladar Megyei Oktato Korhaz ( Site 0062)

    Győr, Győr-Moson-Sopron, 9024, Hungary

  • Policlinico Gemelli di Roma ( Site 0174)

    Roma, 00168, Italy

  • Rabin Medical Center ( Site 0074)

    Petah Tikva, 4941492, Israel

  • Rambam Health Care Campus-Oncology ( Site 0076)

    Haifa, 3109601, Israel

  • Samsung Medical Center ( Site 0082)

    Seoul, 06351, South Korea

  • Sanford Cancer Center ( Site 0038)

    Sioux Falls, South Dakota, 57104, United States

  • Sanford Fargo Medical Center ( Site 0039)

    Fargo, North Dakota, 58102, United States

  • Seoul National University Bundang Hospital ( Site 0081)

    Seongnam-si, Kyonggi-do, 13620, South Korea

  • Severance Hospital ( Site 0080)

    Seoul, 03722, South Korea

  • Shaare Zedek Medical Center ( Site 0075)

    Jerusalem, 9103102, Israel

  • Soroka Medical Center ( Site 0072)

    Beersheba, 8457108, Israel

  • Sourasky Medical Center ( Site 0077)

    Tel Aviv, 6423906, Israel

  • Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 0152)

    Koszalin, West Pomeranian Voivodeship, 75-581, Poland

  • The University of Texas MD Anderson Cancer Center ( Site 0009)

    Houston, Texas, 77030, United States

  • UCSF Medical Center at Mission Bay ( Site 0007)

    San Francisco, California, 94158, United States

  • University of Kentucky Markey Cancer Center ( Site 0019)

    Lexington, Kentucky, 40536-0293, United States

  • Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit ( Site 0150)

    Gdansk, Pomeranian Voivodeship, 80-952, Poland

Conditions

Explore the condition pages connected to this study.

CARCINOMA, NON-SMALL-CELL LUNG