New hope for Tough-to-Treat lung cancers in early trial

NCT ID NCT04077463

Summary

This early-stage study is testing the safety and effectiveness of new drug combinations for people with advanced non-small cell lung cancer (NSCLC) that has a specific genetic change called an EGFR mutation. The trial is testing a pill called lazertinib alone and combined with an injected drug called amivantamab, and also testing a three-drug combination that includes standard chemotherapy. The main goals are to find safe doses and see if these combinations can shrink tumors in patients whose cancer has progressed after other treatments.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Aichi Cancer Center Hospital

    Nagoya, 464 8681, Japan

  • Asklepios Klinik Gauting GmbH - Asklepios Fachkliniken Munchen-Gauting

    Gauting, 82131, Germany

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Beijing Cancer Hospital

    Beijing, 100142, China

  • Boston University Medical Center

    Boston, Massachusetts, 02118, United States

  • CHU De Poitiers

    Poitiers, 86000, France

  • CHU de la Timone

    Marseille, 13005, France

  • Cedars Sinai Medical Center

    West Hollywood, California, 90048, United States

  • Central Hospital of Jinan

    Jinan, 250013, China

  • Centre Leon Berard

    Lyon, 69373, France

  • Chongqing University Cancer Hospital

    Chongqing, 400030, China

  • Chung Shan Medical University Hospital

    Taichung, 402, Taiwan

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02115, United States

  • Evangelische Lungenklinik Berlin

    Berlin, 13125, Germany

  • H. Lee Moffitt Cancer & Research Institute

    Tampa, Florida, 33612, United States

  • HIA Begin

    Saint-Mandé, 94163, France

  • Hosp Univ Fund Jimenez Diaz

    Madrid, 28040, Spain

  • Hosp Univ Hm Sanchinarro

    Madrid, 28050, Spain

  • Hosp Univ Vall D Hebron

    Barcelona, 8035, Spain

  • Hosp. Gral. Univ. Gregorio Maranon

    Madrid, 28009, Spain

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041, Spain

  • Hosp. Univ. Quiron Dexeus

    Barcelona, 08028, Spain

  • Hosp. Univ. Ramon Y Cajal

    Madrid, 28034, Spain

  • Hosp. Virgen Del Rocio

    Seville, 41013, Spain

  • Hunan Cancer hospital

    Changsha, 410013, China

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • IRCCS Istituto Europeo di Oncologia

    Milan, Italy

  • IRCCS Ospedale San Raffaele

    Milan, 20132, Italy

  • Institut Bergonie

    Bordeaux, 33000, France

  • Institut Curie

    Paris, 75005, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Istituto Nazionale Tumori Fondazione G. Pascale

    Naples, 80131, Italy

  • Kansai Medical University Hospital

    Hirakata, 573 1191, Japan

  • Kaohsiung Medical University Chung Ho Memorial Hospital

    Kaohsiung City, 807, Taiwan

  • Kliniiken der Stadt Köln gGmbH, Krankenhaus Köln-Mehrheim

    Cologne, 51109, Germany

  • Klinikum der Johann Wolfgang Goethe-Universität

    Frankfurt am Main, 60590, Germany

  • Kobe City Medical Center General Hospital

    Kobe, 650 0047, Japan

  • Langone Health at NYC University, NYU School of Medicine

    New York, New York, 10016, United States

  • Lungenklinik Hemer

    Hemer, 58675, Germany

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • National Cancer Center Hospital

    Chūōku, 104 0045, Japan

  • National Cancer Center Hospital East

    Kashiwa, 277 8577, Japan

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • Okayama University Hospital

    Okayama, 700 8558, Japan

  • Oncologic Hospital, Puerto Rico Medical Center

    Rio Piedras, OO935, Puerto Rico

  • Ospedale S. Maria Delle Croci

    Ravenna, 48121, Italy

  • Pius-Hospital Oldenburg

    Oldenburg, 26121, Germany

  • Providence Portland Medical Center

    Portland, Oregon, 97213, United States

  • Robert-Bosch-Krankenhaus - Klinik Schillerhoehe

    Stuttgart, 70376, Germany

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • San Gerardo Hospital

    Monza, 20052, Italy

  • Seoul National University Bundang Hospital

    Seongnam-si, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System

    Seoul, 03722, South Korea

  • Shanghai Chest Hospital

    Shanghai, 200030, China

  • Shengjing Hospital Of China Medical University

    Shenyang, 110022, China

  • Shizuoka Cancer Center

    Shizuoka, 411 8777, Japan

  • Stanford University Medical Center

    Stanford, California, 94305, United States

  • Städtisches Krankenhaus Martha-Maria Halle-Dölau gGmbH

    Halle, 06120, Germany

  • The Fifth Affiliated Hospital of Guangzhou Medical University

    Guangzhou, 440112, China

  • The First Affiliated Hospital of Xian Jiaotong University

    Xi'an, 710061, China

  • The First Bethune Hospital of Jilin University

    Changchun, 130021, China

  • The Second Affiliated Hospital of Kunming Medical University

    Kunming, 650101, China

  • Tianjin Medical University Cancer Institute and Hospital

    Tianjin, 300000, China

  • UCSF Helen Diller Comprehensive

    San Francisco, California, 94158, United States

  • USC Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

  • Uniklinik Köln

    Cologne, 50937, Germany

  • Union Hospital Tongji Medical College of Huazhong University of Science and Technology

    Wuhan, 430022, China

  • Universitaetsklinikum Essen

    Essen, 45147, Germany

  • University of California Irvine

    Orange, California, 92868, United States

  • University of Pennsylvania Division of Hematology Oncology Perelman Center for Advanced Medicine

    Philadelphia, Pennsylvania, 19104, United States

  • University of Washington

    Seattle, Washington, 98109, United States

  • Virginia Cancer Specialists

    Fairfax, Virginia, 22031, United States

  • Washington University School Of Medicine

    St Louis, Missouri, 63110, United States

  • West China School of Medicine/West China Hospital, Sichuan University

    Chengdu, 610041, China

  • Zhejiang Cancer Hospital

    Hangzhou, 310022, China

Conditions

Explore the condition pages connected to this study.