New hope for Tough-to-Treat lung cancers in early trial
NCT ID NCT04077463
Summary
This early-stage study is testing the safety and effectiveness of new drug combinations for people with advanced non-small cell lung cancer (NSCLC) that has a specific genetic change called an EGFR mutation. The trial is testing a pill called lazertinib alone and combined with an injected drug called amivantamab, and also testing a three-drug combination that includes standard chemotherapy. The main goals are to find safe doses and see if these combinations can shrink tumors in patients whose cancer has progressed after other treatments.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Aichi Cancer Center Hospital
Nagoya, 464 8681, Japan
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Asklepios Klinik Gauting GmbH - Asklepios Fachkliniken Munchen-Gauting
Gauting, 82131, Germany
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Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Beijing Cancer Hospital
Beijing, 100142, China
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Boston University Medical Center
Boston, Massachusetts, 02118, United States
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CHU De Poitiers
Poitiers, 86000, France
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CHU de la Timone
Marseille, 13005, France
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Cedars Sinai Medical Center
West Hollywood, California, 90048, United States
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Central Hospital of Jinan
Jinan, 250013, China
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Centre Leon Berard
Lyon, 69373, France
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Chongqing University Cancer Hospital
Chongqing, 400030, China
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Chung Shan Medical University Hospital
Taichung, 402, Taiwan
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Columbia University Medical Center
New York, New York, 10032, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Evangelische Lungenklinik Berlin
Berlin, 13125, Germany
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H. Lee Moffitt Cancer & Research Institute
Tampa, Florida, 33612, United States
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HIA Begin
Saint-Mandé, 94163, France
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Hosp Univ Fund Jimenez Diaz
Madrid, 28040, Spain
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Hosp Univ Hm Sanchinarro
Madrid, 28050, Spain
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Hosp Univ Vall D Hebron
Barcelona, 8035, Spain
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Hosp. Gral. Univ. Gregorio Maranon
Madrid, 28009, Spain
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Hosp. Univ. 12 de Octubre
Madrid, 28041, Spain
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Hosp. Univ. Quiron Dexeus
Barcelona, 08028, Spain
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Hosp. Univ. Ramon Y Cajal
Madrid, 28034, Spain
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Hosp. Virgen Del Rocio
Seville, 41013, Spain
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Hunan Cancer hospital
Changsha, 410013, China
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Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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IRCCS Istituto Europeo di Oncologia
Milan, Italy
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IRCCS Ospedale San Raffaele
Milan, 20132, Italy
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Institut Bergonie
Bordeaux, 33000, France
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Institut Curie
Paris, 75005, France
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Institut Gustave Roussy
Villejuif, 94805, France
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Istituto Nazionale Tumori Fondazione G. Pascale
Naples, 80131, Italy
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Kansai Medical University Hospital
Hirakata, 573 1191, Japan
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Kaohsiung Medical University Chung Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
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Kliniiken der Stadt Köln gGmbH, Krankenhaus Köln-Mehrheim
Cologne, 51109, Germany
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Klinikum der Johann Wolfgang Goethe-Universität
Frankfurt am Main, 60590, Germany
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Kobe City Medical Center General Hospital
Kobe, 650 0047, Japan
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Langone Health at NYC University, NYU School of Medicine
New York, New York, 10016, United States
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Lungenklinik Hemer
Hemer, 58675, Germany
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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National Cancer Center Hospital
Chūōku, 104 0045, Japan
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National Cancer Center Hospital East
Kashiwa, 277 8577, Japan
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National Cheng Kung University Hospital
Tainan, 704, Taiwan
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National Taiwan University Hospital
Taipei, 10002, Taiwan
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Okayama University Hospital
Okayama, 700 8558, Japan
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Oncologic Hospital, Puerto Rico Medical Center
Rio Piedras, OO935, Puerto Rico
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Ospedale S. Maria Delle Croci
Ravenna, 48121, Italy
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Pius-Hospital Oldenburg
Oldenburg, 26121, Germany
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Providence Portland Medical Center
Portland, Oregon, 97213, United States
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Robert-Bosch-Krankenhaus - Klinik Schillerhoehe
Stuttgart, 70376, Germany
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Samsung Medical Center
Seoul, 06351, South Korea
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San Gerardo Hospital
Monza, 20052, Italy
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Seoul National University Bundang Hospital
Seongnam-si, 13620, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital Yonsei University Health System
Seoul, 03722, South Korea
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Shanghai Chest Hospital
Shanghai, 200030, China
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Shengjing Hospital Of China Medical University
Shenyang, 110022, China
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Shizuoka Cancer Center
Shizuoka, 411 8777, Japan
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Stanford University Medical Center
Stanford, California, 94305, United States
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Städtisches Krankenhaus Martha-Maria Halle-Dölau gGmbH
Halle, 06120, Germany
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The Fifth Affiliated Hospital of Guangzhou Medical University
Guangzhou, 440112, China
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The First Affiliated Hospital of Xian Jiaotong University
Xi'an, 710061, China
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The First Bethune Hospital of Jilin University
Changchun, 130021, China
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The Second Affiliated Hospital of Kunming Medical University
Kunming, 650101, China
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Tianjin Medical University Cancer Institute and Hospital
Tianjin, 300000, China
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UCSF Helen Diller Comprehensive
San Francisco, California, 94158, United States
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USC Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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Uniklinik Köln
Cologne, 50937, Germany
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Union Hospital Tongji Medical College of Huazhong University of Science and Technology
Wuhan, 430022, China
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Universitaetsklinikum Essen
Essen, 45147, Germany
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University of California Irvine
Orange, California, 92868, United States
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University of Pennsylvania Division of Hematology Oncology Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania, 19104, United States
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University of Washington
Seattle, Washington, 98109, United States
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Virginia Cancer Specialists
Fairfax, Virginia, 22031, United States
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Washington University School Of Medicine
St Louis, Missouri, 63110, United States
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West China School of Medicine/West China Hospital, Sichuan University
Chengdu, 610041, China
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Zhejiang Cancer Hospital
Hangzhou, 310022, China
Conditions
Explore the condition pages connected to this study.