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Major lung cancer trial halted early after testing Triple-Drug attack

NCT ID NCT03631199

Terminated Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This large, late-stage trial tested whether adding an anti-inflammatory drug called canakinumab to standard first-line treatment (chemotherapy plus an immunotherapy drug) could better control advanced non-small cell lung cancer. It involved 673 patients who had not received prior treatment for their advanced cancer. The study was designed to see if the three-drug combination helped patients live longer without their cancer getting worse, but the trial was terminated before completion.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AdventHealth

    Orlando, Florida, 32804, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Novartis Investigative Site

    Caba, Buenos Aires, C1426ANZ, Argentina

  • Novartis Investigative Site

    Caba, C1431FWO, Argentina

  • Novartis Investigative Site

    Westmead, New South Wales, 2145, Australia

  • Novartis Investigative Site

    Wooloongabba, Queensland, 4102, Australia

  • Novartis Investigative Site

    Melbourne, Victoria, 3000, Australia

  • Novartis Investigative Site

    Murdoch, Western Australia, 6150, Australia

  • Novartis Investigative Site

    Linz, Upper Austria, 4020, Austria

  • Novartis Investigative Site

    Salzburg, 5020, Austria

  • Novartis Investigative Site

    Barretos, São Paulo, 14784 400, Brazil

  • Novartis Investigative Site

    São Paulo, São Paulo, 01246 000, Brazil

  • Novartis Investigative Site

    São Paulo, São Paulo, 04014-002, Brazil

  • Novartis Investigative Site

    Edmonton, Alberta, T6G 1Z2, Canada

  • Novartis Investigative Site

    Brampton, Ontario, L6R 3J7, Canada

  • Novartis Investigative Site

    Toronto, Ontario, M5G 2M9, Canada

  • Novartis Investigative Site

    Temuco, Región de la Araucanía, 4810469, Chile

  • Novartis Investigative Site

    Santiago, 8420383, Chile

  • Novartis Investigative Site

    Harbin, Heilongjiang, 150081, China

  • Novartis Investigative Site

    Wuhan, Hubei, 430022, China

  • Novartis Investigative Site

    Wuhan, Hubei, 430030, China

  • Novartis Investigative Site

    Changsha, Hunan, 410013, China

  • Novartis Investigative Site

    Changchun, Jilin, 130012, China

  • Novartis Investigative Site

    Xi’an, Shanxi, 710038, China

  • Novartis Investigative Site

    Hangzhou, Zhejiang, 310022, China

  • Novartis Investigative Site

    Beijing, 100036, China

  • Novartis Investigative Site

    Valledupar, Cesar Department, 200001, Colombia

  • Novartis Investigative Site

    Ostrava, Vitkovice, 703 84, Czechia

  • Novartis Investigative Site

    Brno, 625 00, Czechia

  • Novartis Investigative Site

    Brno, 656 53, Czechia

  • Novartis Investigative Site

    Prague, 128 08, Czechia

  • Novartis Investigative Site

    Herning, 7400, Denmark

  • Novartis Investigative Site

    Oulu, FIN-90220, Finland

  • Novartis Investigative Site

    Marseille, Bouches Du Rhone, 13915, France

  • Novartis Investigative Site

    Lyon, 69373, France

  • Novartis Investigative Site

    Montpellier, 34070, France

  • Novartis Investigative Site

    Nantes, 44093, France

  • Novartis Investigative Site

    Paris, 75231, France

  • Novartis Investigative Site

    Munich, Bavaria, 81377, Germany

  • Novartis Investigative Site

    Göttingen, Lower Saxony, 37075, Germany

  • Novartis Investigative Site

    Cologne, North Rhine-Westphalia, 50937, Germany

  • Novartis Investigative Site

    Cologne, North Rhine-Westphalia, 51109, Germany

  • Novartis Investigative Site

    Dresden, Saxony, 01307, Germany

  • Novartis Investigative Site

    Leipzig, Saxony, 04347, Germany

  • Novartis Investigative Site

    Halle, Saxony-Anhalt, 06120, Germany

  • Novartis Investigative Site

    Berlin, 13125, Germany

  • Novartis Investigative Site

    Essen, 45147, Germany

  • Novartis Investigative Site

    Georgsmarienhütte, 49124, Germany

  • Novartis Investigative Site

    Gerlingen, 70839, Germany

  • Novartis Investigative Site

    Heidelberg, 69120, Germany

  • Novartis Investigative Site

    Athens, GR, 115 27, Greece

  • Novartis Investigative Site

    Athens, 185 47, Greece

  • Novartis Investigative Site

    Kowloon, 999999, Hong Kong

  • Novartis Investigative Site

    Veszprém, 8200, Hungary

  • Novartis Investigative Site

    Reykjavik, 101, Iceland

  • Novartis Investigative Site

    Hyderabad, Andhra Pradesh, 500034, India

  • Novartis Investigative Site

    Gurgaon, Haryana, 122 001, India

  • Novartis Investigative Site

    Pune, Maharashtra, 411013, India

  • Novartis Investigative Site

    Jaipur, Rajasthan, 302017, India

  • Novartis Investigative Site

    Hyderabad, Telangana, 500082, India

  • Novartis Investigative Site

    Kolkata, West Bengal, 700160, India

  • Novartis Investigative Site

    Avellino, AV, 83100, Italy

  • Novartis Investigative Site

    Genova, GE, 16132, Italy

  • Novartis Investigative Site

    Milan, MI, 20132, Italy

  • Novartis Investigative Site

    Milan, MI, 20133, Italy

  • Novartis Investigative Site

    Milan, MI, 20141, Italy

  • Novartis Investigative Site

    Rozzano, MI, 20089, Italy

  • Novartis Investigative Site

    Modena, MO, 41124, Italy

  • Novartis Investigative Site

    Padua, PD, 35128, Italy

  • Novartis Investigative Site

    Perugia, PG, 06129, Italy

  • Novartis Investigative Site

    Parma, PR, 43126, Italy

  • Novartis Investigative Site

    Orbassano, TO, 10043, Italy

  • Novartis Investigative Site

    Nagoya, Aichi-ken, 464 8681, Japan

  • Novartis Investigative Site

    Sapporo, Hokkaido, 0608648, Japan

  • Novartis Investigative Site

    Himeji, Hyōgo, 670-8520, Japan

  • Novartis Investigative Site

    Yokohama, Kanagawa, 241-8515, Japan

  • Novartis Investigative Site

    Sakai, Osaka, 591-8555, Japan

  • Novartis Investigative Site

    Sunto Gun, Shizuoka, 411 8777, Japan

  • Novartis Investigative Site

    Chuo Ku, Tokyo, 1040045, Japan

  • Novartis Investigative Site

    Ube, Yamaguchi, 755-0241, Japan

  • Novartis Investigative Site

    Osaka, 5458586, Japan

  • Novartis Investigative Site

    Beirut, 166830, Lebanon

  • Novartis Investigative Site

    Saida, 652, Lebanon

  • Novartis Investigative Site

    Kuala Lumpur, Kuala Lumpur, 50586, Malaysia

  • Novartis Investigative Site

    Kuantan, Pahang, 25100, Malaysia

  • Novartis Investigative Site

    Kuching, Sarawak, 93586, Malaysia

  • Novartis Investigative Site

    Kuala Lumpur, 59100, Malaysia

  • Novartis Investigative Site

    Groningen, 9713 GZ, Netherlands

  • Novartis Investigative Site

    Groningen, 9728 NZ, Netherlands

  • Novartis Investigative Site

    Drammen, 3004, Norway

  • Novartis Investigative Site

    City of Taguig, National Capital Region, 1634, Philippines

  • Novartis Investigative Site

    Makati City, 1229, Philippines

  • Novartis Investigative Site

    Quezon, 1102, Philippines

  • Novartis Investigative Site

    San Juan City, 1502, Philippines

  • Novartis Investigative Site

    Gliwice, 44 101, Poland

  • Novartis Investigative Site

    Poznan, 60 569, Poland

  • Novartis Investigative Site

    Tomaszw Mazowiecki, 97-200, Poland

  • Novartis Investigative Site

    Lisbon, 1769 001, Portugal

  • Novartis Investigative Site

    Porto, 4200-072, Portugal

  • Novartis Investigative Site

    Cluj-Napoca, Cluj, 400015, Romania

  • Novartis Investigative Site

    Craiova, Dolj, 200347, Romania

  • Novartis Investigative Site

    Arkhangelsk, 163045, Russia

  • Novartis Investigative Site

    Omsk, 644013, Russia

  • Novartis Investigative Site

    Saint Petersburg, 192148, Russia

  • Novartis Investigative Site

    Saint Petersburg, 196603, Russia

  • Novartis Investigative Site

    Saint Petersburg, 197022, Russia

  • Novartis Investigative Site

    Singapore, 119228, Singapore

  • Novartis Investigative Site

    Singapore, 168583, Singapore

  • Novartis Investigative Site

    Singapore, S308433, Singapore

  • Novartis Investigative Site

    Bratislava, 83310, Slovakia

  • Novartis Investigative Site

    Kosice-Saca, 958 01, Slovakia

  • Novartis Investigative Site

    Gyeonggi-do, Korea, 10408, South Korea

  • Novartis Investigative Site

    Seoul, Korea, 03080, South Korea

  • Novartis Investigative Site

    Seoul, 03722, South Korea

  • Novartis Investigative Site

    Seoul, 05505, South Korea

  • Novartis Investigative Site

    Seoul, 06591, South Korea

  • Novartis Investigative Site

    Granada, Andalusia, 18014, Spain

  • Novartis Investigative Site

    Badalona, Barcelona, 08916, Spain

  • Novartis Investigative Site

    Donostia / San Sebastian, Gipuzkoa, 20014, Spain

  • Novartis Investigative Site

    Las Palmas de Gran C, Las Palmas, 35016, Spain

  • Novartis Investigative Site

    Barcelona, 08035, Spain

  • Novartis Investigative Site

    Barcelona, 08036, Spain

  • Novartis Investigative Site

    Madrid, 28009, Spain

  • Novartis Investigative Site

    Madrid, 28040, Spain

  • Novartis Investigative Site

    Madrid, 28041, Spain

  • Novartis Investigative Site

    Madrid, 28046, Spain

  • Novartis Investigative Site

    Málaga, 29010, Spain

  • Novartis Investigative Site

    Valencia, 46026, Spain

  • Novartis Investigative Site

    Zaragoza, 50009, Spain

  • Novartis Investigative Site

    Stockholm, 171 76, Sweden

  • Novartis Investigative Site

    Basel, 4031, Switzerland

  • Novartis Investigative Site

    Kaohsiung City, 83301, Taiwan

  • Novartis Investigative Site

    Tainan, 704, Taiwan

  • Novartis Investigative Site

    Taipei, 10002, Taiwan

  • Novartis Investigative Site

    Taipei, 11217, Taiwan

  • Novartis Investigative Site

    Taoyuan District, 333, Taiwan

  • Novartis Investigative Site

    Songkhla, Hat Yai, 90110, Thailand

  • Novartis Investigative Site

    Khon Kaen, THA, 40002, Thailand

  • Novartis Investigative Site

    Bangkok, 10330, Thailand

  • Novartis Investigative Site

    Bangkok, 10400, Thailand

  • Novartis Investigative Site

    Bangkok, 10700, Thailand

  • Novartis Investigative Site

    Istanbul, Bagcilar, 34214, Turkey (Türkiye)

  • Novartis Investigative Site

    Ankara, Bilkent Cankaya, 06800, Turkey (Türkiye)

  • Novartis Investigative Site

    Edirne, Merkez, 22030, Turkey (Türkiye)

  • Novartis Investigative Site

    Ankara, Sihhiye-Altindag, 06230, Turkey (Türkiye)

  • Novartis Investigative Site

    High Heaton, Newcastle Upon Tyne, NE7 7DN, United Kingdom

  • Novartis Investigative Site

    London, NW3 2QG, United Kingdom

  • Novartis Investigative Site

    Manchester, M20 2BX, United Kingdom

  • Novartis Investigative Site

    Plymouth, PL6 8DH, United Kingdom

  • Novartis Investigative Site

    Hanoi, 100000, Vietnam

  • Pacific Shores Medical Group

    Long Beach, California, 90813, United States

  • USC Kenneth Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

Conditions

Explore the condition pages connected to this study.

NON-SMALL CELL LUNG CANCER