Electric field therapy device takes on metastatic lung cancer in major trial

NCT ID NCT06216301

Recruiting now Disease control Sponsor: NovoCure GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether adding a wearable device that delivers electric fields (TTFields) to standard immunotherapy and chemotherapy improves survival in people with metastatic non-small cell lung cancer. About 734 participants who have not had prior treatment for their advanced cancer will be enrolled. The device is used at home and aims to disrupt cancer cell division.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tumor Treating Fields (TTFields) delivered by a portable device, plus pembrolizumab and platinum-based chemotherapy
What this could lead to: If successful, this could provide a new treatment option that extends survival for people with advanced lung cancer by adding TTFields to standard immunotherapy and chemotherapy.
What could go wrong: This is a Phase 3 trial, but results are not yet known. Adding a device may increase side effects or burden without clear benefit. The study is large but still experimental.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Neoplasm Metastasis non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC NON-SMALL CELL LUNG CANCER

Contacts and locations

Show contact details

Locations

A.O. SS. Antonio e Biagio e Cesare Arrigo di Alessandria
RECRUITING

Alessandria, 15121, Italy
AHN Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States

Contact Email: •••••@•••••
AZ Maria Middelares - Campus Maria Middelares
RECRUITING

Ghent, 9000, Belgium
Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Azienda Ospedaliera Universitaria Senese Policlinico Le Scotte
RECRUITING

Siena, 53100, Italy
Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant'Anna
RECRUITING

Ferrara, 44124, Italy
Azienda Sanitaria Territoriale Pesaro Urbino
RECRUITING

Pesaro, 61122, Italy
Bacs-Kiskun Varmegyei Oktatokorhaz
RECRUITING

Kecskemét, 6000, Hungary
Bnai zion MC
RECRUITING

Haifa, 34561, Israel
CHU Limoges
RECRUITING

Limoges, 87000, France
CHU de Bordeaux
RECRUITING

Pessac, 33604, France
Cancer Treatment Centers of America (CTCA)
RECRUITING

Zion, Illinois, 60099, United States
Cantonal Hospital Baden
RECRUITING

Baden, 5404, Switzerland
Central Alabama Research
RECRUITING

Birmingham, Alabama, 35209, United States
Centre Hospitalier Intercommunal de Creteil
RECRUITING

Créteil, 94010, France
Centre Hospitalier Lyon Sud
RECRUITING

Pierre-Bénite, 69495, France
Charing Cross Hospital
RECRUITING

London, Greater London, United Kingdom
Clatterbridge Cancer Centre - Liverpool
RECRUITING

Liverpool, Merseyside, L7 8YA, United Kingdom
Clinica Mi Tres Torres Barcelona - Giromed Institute
RECRUITING

Barcelona, Catalonia, 8017, Spain
Clinica Universidad de Navarra
RECRUITING

Pamplona, 31008, Spain
Clinica Universidad de Navarra (Madrid)
RECRUITING

Madrid, 28027, Spain
Cliniques universitaires Saint-Luc
RECRUITING

Brussels, 1200, Belgium
Curie Oncology
RECRUITING

Singapore, 329563, Singapore

Contact Email: •••••@•••••
DHR Health Oncology Institute
RECRUITING

Edinburg, Texas, 78539, United States
Edward Cancer Center
RECRUITING

Naperville, Illinois, 60540-6766, United States
Elmhurst Hospital Nancy Knowles Cancer Center
RECRUITING

Elmhurst, Illinois, 60126, United States
Emek Medical Center
RECRUITING

Afula, 1834111, Israel
Evangelische Lungenklinik Berlin
RECRUITING

Berlin, 13125, Germany
Fakultni nemocnice Olomouc FNOL
RECRUITING

Olomouc, 779 00, Czechia
Farkasgyepui Tudogyogyintezet
RECRUITING

Farkasgyepű, 8582, Hungary
Florida Cancer Affiliates - Ocala Oncology
RECRUITING

Ocala, Florida, 34474, United States
Franciscan Health Indianapolis
RECRUITING

Indianapolis, Indiana, 46237, United States
General University Hospital in Prague
RECRUITING

Prague, 12808, Czechia
HFR Freiburg-Kantonsspital
RECRUITING

Fribourg, 1752, Switzerland
Hoag Family Cancer Institute - Hoag Memorial Hospital
RECRUITING

Newport Beach, California, 92663, United States
Hopital Europeen
RECRUITING

Marseille, 13003, France
Hopital Prive du Confluent
RECRUITING

Nantes, 44277, France
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, 29010, Spain
Hospital Ruber Internacional
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Arnau de Vilanova
RECRUITING

Lleida, 25198, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, Andalusia, 41013, Spain
Hospital Universitario de Torrejon
RECRUITING

Torrejón de Ardoz, Madrid, 28850, Spain
Hospital Universitario del Vinalopo
RECRUITING

Elche, Alicante, 3293, Spain
Houston Methodist Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Humanitas Gavazzeni
RECRUITING

Bergamo, 24125, Italy
IRCCS - Istituto Romagnolo per lo Studio Dei Tumori, Dino Amadori
RECRUITING

Meldola, 47014, Italy
Icon Cancer Centre Singapore (Singapore Oncology Consultants)
RECRUITING

Singapore, 574623, Singapore
Institut Catala d'Oncologia
RECRUITING

Barcelona, 8916, Spain
Institut Curie
RECRUITING

Paris, 75005, France
Jason Bates at University of Texas Health Science Center
RECRUITING

San Antonio, Texas, 78229, United States
Karl Landsteiner Institut fur Lungenforschung und pneumologische Onkologie c/o Klinik Floridsdorf
RECRUITING

Vienna, 1210, Austria
Klinik Loewenstein gGmbH
RECRUITING

Löwenstein, 74245, Germany
Krankenhaus Martha-Maria Halle-Dolau
RECRUITING

Halle, 06120, Germany
Luminis Health Radiation Oncology - Anne Arundel Health System
RECRUITING

Annapolis, Missouri, 21401, United States
Medisch Centrum Leeuwarden (MCL) - Oncologisch Centrum Leeuwarden (OCL)
RECRUITING

Friesland, 8934 AD, Netherlands
Methodist Richardson Cancer Center
RECRUITING

Richardson, Texas, 75082, United States

Contact Email: •••••@•••••
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
RECRUITING

Spokane, Washington, 99218, United States
MultiCare Institute for Research & Innovation
RECRUITING

Tacoma, Washington, 98405, United States
MultiCare Regional Cancer Center
RECRUITING

Auburn, Washington, 98001, United States
MultiCare Regional Cancer Center
RECRUITING

Gig Harbor, Washington, 98335, United States
MultiCare Regional Cancer Center
RECRUITING

Puyallup, Washington, 98372, United States
NCCS Singapore
RECRUITING

Singapore, 168583, Singapore

Contact Email: •••••@•••••
Nemocnice Agel Ostrava-Vitkovice / Agel Ostrava-Vitkovice Hospital
RECRUITING

Ostrava, 70300, Czechia
New York Cancer & Blood Specialists (NYCBS)
RECRUITING

New Hyde Park, New York, 11042, United States
New York Cancer & Blood Specialists (NYCBS)
RECRUITING

New York, New York, 10028, United States
New York Cancer & Blood Specialists (NYCBS)
RECRUITING

Shirley, New York, 19967, United States
New York Cancer & Blood Specialists (NYCBS)
RECRUITING

The Bronx, New York, 10469, United States
Northwest Oncology & Hematology
RECRUITING

Barrington, Illinois, 60010, United States
Nouvel Hopital Civil (NHC)
RECRUITING

Strasbourg, 67091, France
Old Parkland Hospital Hematology Oncology Clinic
RECRUITING

Dallas, Texas, 75235, United States
Ospedale Isola Tiberina Gemelli
RECRUITING

Rome, 00186, Italy
Parkview Packnett Family Cancer Institute
RECRUITING

Fort Wayne, Indiana, 46845, United States
Pius-Hospital Oldenburg
RECRUITING

Oldenburg, 26121, Germany
Rijnstate Ziekenhuis
RECRUITING

Arnhem, 6815AD, Netherlands
Saitama Medical University International Medical Center
RECRUITING

Hidaka, Saitama, 350-1298, Japan
St Antonius Ziekenhuis
RECRUITING

Utrecht, 3543 AZ, Netherlands
St. Jansdal ziekenhuis
RECRUITING

Harderwijk, 3844 DG, Netherlands
St. Jude Herritage Medical Group
RECRUITING

Fullerton, California, 92835, United States
Sutter Institute for Medical Research
RECRUITING

Sacramento, California, 95816, United States
The Royal Marsden NHS Foundation Trust
RECRUITING

London, London, SW3 6JJ, United Kingdom
The Royal Marsden NHS Foundation Trust - Sutton
RECRUITING

Sutton, Sutton, SM2 5PT, United Kingdom
Thoraxklinik Heidelberg
RECRUITING

Heidelberg, 69126, Germany
Tolna Varmegyei Balassa Janos Korhaz
RECRUITING

Szekszárd, 7100, Hungary
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75235, United States
Universita Campus Bio-Medico di Roma (UCBM) - Policlinico Universitario
RECRUITING

Roma, 00128, Italy
Universitaetsklinik fuer Innere Medizin V Innsbruck
RECRUITING

Innsbruck, 6020, Austria
University Hospital Giessen, ZIM IV
RECRUITING

Giessen, 35392, Germany
University Hospital Salzburg
RECRUITING

Salzburg, 5020, Austria
University Hospitals of Leicester NHS Trust
RECRUITING

Leicester, Leicestershire, LE1 5WW, United Kingdom
University of Kansas Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Kansas Cancer Center - Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North
RECRUITING

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center - Overland Park
RECRUITING

Overland, Missouri, 66210, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
Uniwersytecki Szpital Kliniczny
RECRUITING

Poznan, 60-693, Poland
WakeMed Health & Hospitals
RECRUITING

Cary, North Carolina, 27518, United States
Western Regional Medical Center, LLC
RECRUITING

Goodyear, Arizona, 85338, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.