Can spacing out radioactive drug doses reduce side effects in neuroendocrine tumors?
NCT ID NCT06878664
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares two schedules of the radioactive drug Lu177-Dotatate in 166 people with slow-growing midgut neuroendocrine tumors. One group gets the drug every 8 weeks (standard), the other every 16 weeks. The goal is to see if the less frequent schedule causes fewer blood-related side effects while still controlling the tumor. Participants must have tumors that express somatostatin receptors and have shown slow progression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Lu177-Dotatate (a radioactive drug that targets tumor cells)
- What this could lead to
- If successful, this could show that a less frequent dosing schedule of Lu177-Dotatate is safer and just as effective for controlling slow-growing midgut neuroendocrine tumors.
- What could go wrong
- This is a Phase 2/3 trial with 166 patients, so results are not yet proven. The less frequent schedule might be less effective at controlling the tumor, and side effects like blood toxicity or secondary cancers remain possible.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre Eugène MARQUIS
NOT_YET_RECRUITINGRennes, Rennes, 35000, France
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Centre François BACLESSE
NOT_YET_RECRUITINGCaen, Caen, 14000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chu Dijon
NOT_YET_RECRUITINGDijon, Dijon, 21000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Complexo Hospitalario Universitario de Santiago
NOT_YET_RECRUITINGSantiago de Compostela, La Coruña, 15706, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hopital BEAUJON
NOT_YET_RECRUITINGClichy, Paris, 92110, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hopital COCHIN
NOT_YET_RECRUITINGParis, Paris, 75014, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospices civiles de Lyon
NOT_YET_RECRUITINGLyon, Lyon, 69002, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital 12 de Octubre
RECRUITINGMadrid, Madrid, 28041, Spain
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Hospital Center University De Lille
NOT_YET_RECRUITINGLille, Lille, 59000, France
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Hospital Clínico de Valencia
RECRUITINGValencia, Valencia, 46010, Spain
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Hospital General Universitario Gregorio Marañón
NOT_YET_RECRUITINGMadrid, Madrid, 28007, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitari Vall d'Hebrón
RECRUITINGBarcelona, Barcelona, 08035, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario Central de Asturias
NOT_YET_RECRUITINGOviedo, Principality of Asturias, 33011, Spain
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Hospital Universitario La Paz
NOT_YET_RECRUITINGMadrid, Madrid, 28046, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario Ramón y Cajal
RECRUITINGMadrid, Madrid, 28034, Spain
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Hospital Universitario Virgen del Rocío
NOT_YET_RECRUITINGSeville, Sevilla, 41013, Spain
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Hospital Universitario de Burgos
RECRUITINGBurgos, Balearic Islands, 09006, Spain
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Hospital Universitario y Politécnico La Fe
RECRUITINGValencia, Valencia, 46026, Spain
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Hospital Virgen de las Nieves de Granada
RECRUITINGGranada, Granada, 18014, Spain
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Institut Paoli Calmette
NOT_YET_RECRUITINGMarseille, Marseille, 13009, France
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Instituto Catalán de Oncología - Hospital Duran i Reynals
RECRUITINGL'Hospitalet de Llobregat, Barcelona, 08908, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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