Drug trial aims to slow muscle loss in rare genetic disease
NCT ID NCT05397470
Summary
This study tested whether an oral drug called losmapimod could slow the progression of muscle weakness in adults with facioscapulohumeral muscular dystrophy (FSHD). For 48 weeks, 260 participants took either the drug or a placebo pill twice daily. The main goal was to see if the drug helped people maintain their ability to reach and move their arms, a key measure of upper body function in FSHD.
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Contacts and locations
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Locations
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Aarhus Universitetshospital
Aarhus, 8200, Denmark
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Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, 20133, Italy
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Fondazione Serena Onlus- Centro Clinico NEMO
Milan, Lombardy, 20162, Italy
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Hospital Universitari i Politecnic La Fe
Valencia, 46026, Spain
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Hospital Universitario Donostia
San Sebastián, Guipuzkoa, 20014, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, 08035, Spain
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Institute de Myologie, Groupe Hospitalier Pitié-Salpêtrière
Paris, 75013, France
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Kennedy Krieger Institute
Baltimore, Maryland, 21205, United States
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LMU Klinikum Ludwig-Maximilians-Universität München
München, 80336, Germany
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Leiden University Medical Centre
Leiden, Southern Holland, 2333 ZA, Netherlands
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Montreal Neurological Institute and Hospital
Montreal, Quebec, H3A 2B4, Canada
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Newcastle upon Tyne NHS Foundation Trust
Newcastle upon Tyne, NE1 3BZ, United Kingdom
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Nice University Hospital - CHU Nice
Nice, PACA, 06001, France
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Ohio State University Medical Center
Columbus, Ohio, 43210, United States
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Radboudumc
Nijmegen, Gelderland, 9101, Netherlands
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Rigshospitalet
Copenhagen, 2100, Denmark
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The Ottawa Hospital Research Institute
Ottawa, Ontario, K1Y 4E9, Canada
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University College of London Hospitals
London, WC1N 3BG, United Kingdom
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University Hospital Bonn
Bonn, 53127, Germany
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University of Calgary
Calgary, Alberta, T2N 4Z6, Canada
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University of California Irvine
Irvine, California, 92868, United States
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University of California Los Angeles (UCLA)
Los Angeles, California, 90095, United States
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University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045, United States
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University of Florida
Gainesville, Florida, 32610, United States
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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University of Massachusetts Memorial Medical Center
Worcester, Massachusetts, 01655, United States
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University of Rochester Medical Center
Rochester, New York, 14642, United States
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University of Utah
Salt Lake City, Utah, 84132, United States
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University of Washington Medical Center
Seattle, Washington, 98195, United States
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Universitätsklinikum Ulm
Ulm, 89081, Germany
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Virginia Commonwealth University
Richmond, Virginia, 23298, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
Conditions
Explore the condition pages connected to this study.