Head-to-Head trial tests Next-Gen drug against standard for tough lung cancer

NCT ID NCT03052608

Summary

This study tested whether a newer drug called lorlatinib works better than the standard drug crizotinib for people with advanced non-small cell lung cancer that has a specific genetic change (ALK-positive). The trial involved 296 adults who had not received any prior treatment for their advanced cancer. Researchers directly compared the two drugs to see which one more effectively delayed cancer growth and helped patients live longer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AOU Policlinico Vittorio Emanuele-P.O.G. Rodolico

    Catania, CT, 95123, Italy

  • ASST Monza - A.O. San Gerardo

    Monza, MB, 20900, Italy

  • Aichi cancer center central hospital

    Nagoya, Aichi-ken, 464-8681, Japan

  • Artemis Hospital

    Gurugram, Haryana, 122001, India

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Ausl della Romagna- Ravenna

    Ravenna, 48121, Italy

  • Az.Osp.San Camillo-Forlanini

    Roma, RM, 00152, Italy

  • Azienda Ospedaliera Dei Colli Ospedale Monaldi

    Naples, 80131, Italy

  • Azienda Ospedaliera di Perugia - Ospedale S. M. Misericordia

    Perugia, PG, 06132, Italy

  • Azienda Ospedaliero-Universitaria di Parma

    Parma, PR, 43126, Italy

  • Beijing Cancer Hospital

    Beijing, 100142, China

  • Bendigo Day Surgery Collection Centre and Laboratory

    Bendigo, Victoria, 3550, Australia

  • Bendigo Medical Imaging, Bendigo Hospital

    Bendigo, Victoria, 3550, Australia

  • Budgetary Healthcare Institution Omsk Region "Clinical Oncological Dispensary"

    Omsk, Omsk Oblast, 644013, Russia

  • CHU de Rennes Hopital Pontchaillou

    Rennes, 35033, France

  • CHU de Rennes, Hopital Pontchaillou

    Rennes, 35033, France

  • Centre Hospitalier du Mans

    Le Mans, 72000, France

  • Centro Medico Austral

    CABA, C1019ABS, Argentina

  • Centro de Investigacion Pergamino SA

    Pergamino, Buenos Aires, B2700CPM, Argentina

  • Centro di Riferimento Oncologico-IRCCS

    Pordenone, PN, 33081, Italy

  • Centrum Medyczne Dom Lekarski S.A.

    Szczecin, 70-784, Poland

  • Chang Gung Memorial Hospital - Kaohsiung Branch

    Kaohsiung City, 83301, Taiwan

  • Chung Shan Medical University Hospital

    Taichung, 402, Taiwan

  • Complejo Hospitalario De Navarra

    Pamplona, Navarre, 31008, Spain

  • Cukurova University Medical Faculty

    Adana, 01330, Turkey (Türkiye)

  • Department d'imagerie medicale

    Villejuif, 94805, France

  • Department of Respiratory,the First Affiliated Hospital of College of Medicine, Zhejiang University

    Hangzhou, Zhejiang, 310003, China

  • Division of Medical Oncology, Severance Hospital, Yonsei University Health System

    Seoul, 03722, South Korea

  • Département d'Imagerie Médicale

    Marseille, 13915, France

  • Ege University Medical Faculty

    Izmir, 35100, Turkey (Türkiye)

  • FSBI "N.N.Blokhin Medical Research Center of Oncology"

    Moscow, 115478, Russia

  • Fakultni nemocnice Olomouc, Klinika plicnich nemoci a tuberkulozy

    Olomouc, 779 00, Czechia

  • Florida Cancer Specialists

    Altamonte Springs, Florida, 32701, United States

  • Florida Cancer Specialists

    Brandon, Florida, 33511, United States

  • Florida Cancer Specialists

    Clearwater, Florida, 33761, United States

  • Florida Cancer Specialists

    Gainesville, Florida, 32605, United States

  • Florida Cancer Specialists

    Largo, Florida, 33770, United States

  • Florida Cancer Specialists

    Lecanto, Florida, 34461, United States

  • Florida Cancer Specialists

    Orange City, Florida, 32763, United States

  • Florida Cancer Specialists

    Orlando, Florida, 32806, United States

  • Florida Cancer Specialists

    Spring Hill, Florida, 34608, United States

  • Florida Cancer Specialists

    St. Petersburg, Florida, 33705, United States

  • Florida Cancer Specialists

    Tampa, Florida, 33607, United States

  • Florida Cancer Specialists

    Tavares, Florida, 32778, United States

  • Florida Cancer Specialists

    The Villages, Florida, 32159, United States

  • Florida Cancer Specialists

    Winter Park, Florida, 32792, United States

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, MI, 20133, Italy

  • Grand Hopital de Charleroi - Site Notre Dame

    Charleroi, 6000, Belgium

  • Groupe Hospitalier Bichat Claude Bernard, AP-HP

    Paris, 75018, France

  • Guangdong General Hospital

    Guangzhou, 510000, China

  • Heart of England NHS Foundation Trust, Birmingham Heartlands Hospital

    Birmingham, WEST Midlands, B9 5SS, United Kingdom

  • Hopital Foch

    Suresnes, 92150, France

  • Hopital Haut-Léveque-Centre François Magendie

    Pessac, Aquitaine, 33604, France

  • Hopital Larrey

    Toulouse, 31059, France

  • Hopital Pierre Paul Riquet

    Toulouse, 31059, France

  • Hopital de Chevilly Larue

    Chevilly-Larue, 94550, France

  • Hospital Clinic i Provincial de Barcelona

    Barcelona, 08036, Spain

  • Hospital Clinico San Carlos

    Madrid, 28040, Spain

  • Hospital De La Santa Creu I Sant Pau

    Barcelona, 08025, Spain

  • Hospital De La Santa Creu I Sant Pau

    Barcelona, 08041, Spain

  • Hospital Teresa Herrera C.H.U.A.C.

    A Coruña, 15006, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040, Spain

  • Hospital Universitario Insular de Gran Canaria

    Las Palmas de Gran Canaria, Canary Islands, 35016, Spain

  • Hospital Universitario La Fe

    Valencia, 46026, Spain

  • Hospital Universitario Puerta de Hierro Majadahonda

    Majadahonda, Madrid, 28222, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034, Spain

  • Hôpital Larrey

    Toulouse, 31059, France

  • Hôpital Nord

    Marseille, 13915, France

  • IRCCS Ospedale San Raffaele

    Milan, MI, 20132, Italy

  • Institut Catala d'Oncologia Girona

    Girona, 17007, Spain

  • Institut Catala d'Oncologia L'Hospitalet

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut Paoli-Calmettes

    Marseille, 13273, France

  • Instituto Nacional de Cancerologia

    Distrito Federal, 14080, Mexico

  • Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas

    Distrito Federal, 14080, Mexico

  • Istanbul University Oncology Institute

    Istanbul, 34093, Turkey (Türkiye)

  • Istituto Clinico Humanitas

    Rozzano, MI, 20089, Italy

  • Istituto Europeo di Oncologia

    Milan, MI, 20141, Italy

  • Istituto Nazionale Tumori Regina Elena

    Roma, RM, 00144, Italy

  • Istituto Nazionale Tumori di Napoli

    Naples, 80131, Italy

  • Jilin Provincial Cancer Hospital

    Changchun, Jilin, 130012, China

  • Kanagawa Cancer Center

    Yokohama, Kanagawa, 241-8515, Japan

  • Kanazawa University Hospital

    Kanazawa, Ishikawa-ken, 920-8641, Japan

  • Kindai University Hospital

    Sayama, Osaka, 589-8511, Japan

  • Klinika Onkologii i Radioterapii Uniwersyteckie Centrum Kliniczne

    Gdansk, 80-214, Poland

  • Kurume University Hospital

    Kurume, Fukuoka, 830-0011, Japan

  • LEC at SBIH "Saint-Petersburg Clinical Research Practical Center of specialized types of

    Pesochniy Poselok, Sankt-Peterburg, 197758, Russia

  • Manipal Hospital

    Bangalore, Karnataka, 560017, India

  • Marmara Univ Pendik Training and Research Hospital

    Istanbul, 34899, Turkey (Türkiye)

  • Massachusetts Eye and Ear Infirmary

    Boston, Massachusetts, 02114, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • McGill University Health Centre

    Montreal, Quebec, H4A 3J1, Canada

  • Med-Polonia Sp. z o.o.

    Poznan, 60-693, Poland

  • Melbourne Pathology

    Bendigo, Victoria, 3550, Australia

  • Médicos Especialistas en Cancer S.C. / San Peregrino.

    Aguascalientes, 20230, Mexico

  • Nagoya University Hospital

    Nagoya, Aichi-ken, 466-8560, Japan

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie-Panstwowy Instytut Badawczy

    Warsaw, 02-781, Poland

  • National Cancer Center Hospital

    Chuo-Ku, Tokyo, 104-0045, Japan

  • National Hospital Organization Hokkaido Cancer Center

    Sapporo, Hokkaido, 003-0804, Japan

  • National Hospital Organization Shikoku Cancer Center

    Matsuyama, Ehime, 791-0280, Japan

  • National Hospital Organization, Yamaguchi-Ube Medical Center

    Ube, Yamaguchi, 755-0241, Japan

  • National Taiwan University Hospital

    Taipei, Taiwan ROC, 10002, Taiwan

  • National University Hospital

    Singapore, 119074, Singapore

  • Niigata Cancer Center Hospital

    Niigata, 951-8566, Japan

  • Okayama University Hospital

    Okayama, 700-8558, Japan

  • Ophthalmic Consultants of Boston Inc

    Boston, Massachusetts, 02114, United States

  • Osaka City General Hospital

    Osaka, 534-0021, Japan

  • Osaka International Cancer Institute

    Osaka, Osaka, 541-8567, Japan

  • Peter MacCallum Cancer Centre

    Melbourne, Victoria, 3000, Australia

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2M9, Canada

  • Private Medical Institution "Euromedservice"

    Pushkin, Sankt-Peterburg, 196603, Russia

  • RBHI Kursk Regional Clinical Oncology Dispensary

    Kislino, Kursk Oblast, 305 524, Russia

  • RBHI Kursk Regional Clinical Oncology Dispensary

    Kursk, 305 035, Russia

  • Raffles Hospital

    Singapore, 188770, Singapore

  • Sahyadri Clinical Research and Development Centre

    Pune, Maharashtra, 411004, India

  • Sahyadri Specialty Hospital

    Pune, Maharashtra, 411004, India

  • Sendai Kousei Hospital

    Sendai, Miyagi, 980-0873, Japan

  • Sendai Kousei Hospital

    Sendai, Miyagi, 981-0914, Japan

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Service Ophtalmologie

    Marseille, 13915, France

  • Shanghai Chest Hospital

    Shanghai, Shanghai Municipality, 200030, China

  • Shizuoka Cancer Center

    Sunto-gun, Shizuoka, 411-8777, Japan

  • Srinivasam Cancer Care Multispeciality Hospitals India Pvt Ltd

    Bangalore, Karnataka, 560072, India

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

  • Technische Universitat Dresden , Medizinische Fakultat Carl Gustav Carus

    Dresden, D-01307, Germany

  • Tennessee Oncology, PLLC

    Dickson, Tennessee, 37055, United States

  • Tennessee Oncology, PLLC

    Franklin, Tennessee, 37067, United States

  • Tennessee Oncology, PLLC

    Gallatin, Tennessee, 37066, United States

  • Tennessee Oncology, PLLC

    Hermitage, Tennessee, 37076, United States

  • Tennessee Oncology, PLLC

    Lebanon, Tennessee, 37090, United States

  • Tennessee Oncology, PLLC

    Murfreesboro, Tennessee, 37129, United States

  • Tennessee Oncology, PLLC

    Nashville, Tennessee, 37203, United States

  • Tennessee Oncology, PLLC

    Nashville, Tennessee, 37205, United States

  • Tennessee Oncology, PLLC

    Nashville, Tennessee, 37207, United States

  • Tennessee Oncology, PLLC

    Nashville, Tennessee, 37211, United States

  • Tennessee Oncology, PLLC

    Shelbyville, Tennessee, 37160, United States

  • Tennessee Oncology, PLLC

    Smyrna, Tennessee, 37167, United States

  • The Affiliated Hospital of Military Medical Sciences

    Beijing, Beijing Municipality, 100071, China

  • The Cancer Institute Hospital of JFCR

    Kōtoku, 135-8550, Japan

  • The Catholic University of Korea, St. Vincents Hospital

    Suwon, Gyeonggi-do, 16247, South Korea

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX, United Kingdom

  • The Ipswich Hospital NHS Trust

    Ipswich, Suffolk, IP4 5PD, United Kingdom

  • The Sarah Cannon Research Institute.

    Nashville, Tennessee, 37203, United States

  • The Second Affiliated Hospital of Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310009, China

  • The University of Hong Kong, Department of Clinical Oncology

    Hong Kong, Hong Kong

  • The University of Hong Kong, Department of Medicine

    Hong Kong, Hong Kong

  • The William P. Beetham Eye Institute, Joslin Diabetes Center

    Boston, Massachusetts, 02215, United States

  • Thoraxklinik Heidelberg gGmbH

    Heidelberg, D-69126, Germany

  • Tokushima University Hospital

    Tokushima, 770-8503, Japan

  • Tuen Mun Hospital

    Hong Kong, Hong Kong

  • Uberortliche Radiologische Gemeinschaftspraxis Dr. med. Marc Amler

    Dresden, 01309, Germany

  • Ulsan University Hospital

    Ulsan, 44033, South Korea

  • Universitatsklinikum Heidelberg

    Heidelberg, D-69126, Germany

  • Universitatsklinikum Regensburg, Institut fur Rontgendiagnostik

    Regensburg, 93053, Germany

  • Universitatsklinikum Regensburg, Klinik und Poliklinik fur Innere Medizin II

    Regensburg, 93053, Germany

  • University Medical Center Groningen

    Groningen, 9713 GZ, Netherlands

  • University of Rochester Cancer Center Pharmacy

    Rochester, New York, 14642, United States

  • University of Rochester Medical Center

    Rochester, New York, 14642, United States

  • University of Washington Medical Center

    Seattle, Washington, 98195, United States

  • Universitätsklinikum des Saarlandes

    Homburg - Saar, 66421, Germany

  • Universitätsklinikum des Saarlandes, Innere Medizin V

    Homburg - Saar, 66421, Germany

  • Vseobecna fakultni nemocnice v Praze

    Prague, 128 08, Czechia

  • Wakayama Medical University Department of Pulmonary Medicine and Oncology

    Wakayama, 641-8509, Japan

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang, 310022, China

Conditions

Explore the condition pages connected to this study.