Real-World check: does lorlatinib work for ALK lung cancer?

NCT ID NCT06487078

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how effective and safe the drug lorlatinib is for people with a specific type of lung cancer (ALK-positive non-small cell lung cancer) who have not had treatment before. Researchers will follow 90 patients in French clinics to see how long they live without the cancer getting worse and track any side effects. The goal is to understand how well the drug works in real-world settings, not just in controlled trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lorlatinib
What this could lead to: If successful, this could confirm that lorlatinib is effective and safe for untreated ALK-positive lung cancer patients in everyday medical practice.
What could go wrong: This is an observational study, not a controlled trial, so results may be less reliable. It is also small (90 patients) and only in France, so findings may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALK+ NON-SMALL-CELL LUNG CARCINOMA

Contacts and locations

Locations

CH ALBI
RECRUITING

Albi, 81000, France
CHBA
RECRUITING

Vannes, 56017, France
CHIC
RECRUITING

Créteil, 94010, France
CHRU Bretonneau
RECRUITING

Tours, 37000, France
CHRU de Nancy
NOT_YET_RECRUITING

Nancy, 54035, France
CHU Nantes
RECRUITING

Nantes, 44093, France
Centre Hospitalier Francois Mitterand
RECRUITING

Pau, 64046, France
Centre Hospitalier du Pays d AIX
RECRUITING

Aix-en-Provence, 13100, France
Centre Leon Berard
NOT_YET_RECRUITING

Lyon, 69373, France
Ch Annecy Genevois
RECRUITING

Pringy, 74374, France
Ch Avignon
NOT_YET_RECRUITING

Avignon, 84000, France
Ch Cornouaille
RECRUITING

Quimper, 29107, France
Ch Troyes
RECRUITING

Troyes, 10003, France
Chits Ch Sainte Musse
NOT_YET_RECRUITING

Toulon, 83000, France
Chu Amiens Sud
RECRUITING

Amiens, 80000, France
Chu Limoges
RECRUITING

Limoges, 87042, France
Clcc Georges Francois Leclerc
RECRUITING

Dijon, 21000, France
Clinique Teissier
RECRUITING

Valenciennes, 59300, France
Hopital Cochin
NOT_YET_RECRUITING

Paris, 75014, France
Hopital Europeen Georges Pompidou
RECRUITING

Paris, 75908, France
Hopital Foch
RECRUITING

Suresnes, 92151, France
Hopital Morvan
NOT_YET_RECRUITING

Brest, 29000, France
Hopital Pontchaillou
RECRUITING

Rennes, 35033, France
Hopital Robert Schuman de Vantoux
RECRUITING

Metz, 57070, France
Hopital Saint Joseph
RECRUITING

Paris, 75674, France
Hopital de Rangueil
RECRUITING

TSA 50032 Toulouse, 31059, France
Hopital de Villefranche Sur Saone
NOT_YET_RECRUITING

Gleizé, 69400, France
Institut Bergonie
NOT_YET_RECRUITING

Bordeaux, 33076, France
Institut Curie
RECRUITING

Paris, Paris, 75005, France
Institut Godinot
RECRUITING

Reims, 51056, France
Polyclinique Bordeaux Nord Aquitaine
NOT_YET_RECRUITING

Bordeaux, 30072, France