New hope for lung cancer patients: lorlatinib shows promise after other treatments fail

NCT ID NCT03909971

First seen Nov 05, 2025 · Last updated May 15, 2026 · Updated 25 times

Summary

This study tested a drug called lorlatinib in 109 Chinese patients with advanced ALK-positive non-small cell lung cancer whose disease had worsened after previous ALK inhibitor treatment. The goal was to see how many patients' tumors shrank or disappeared. Results help doctors understand if lorlatinib can control the cancer when other drugs stop working.

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Contacts and locations

Locations

  • Beijing Cancer Hospital

    Beijing, Beijing Municipality, 100142, China

  • Beijing Chest Hospital, Capital Medical University

    Beijing, 101149, China

  • Fifth Medical Center of PLA General Hospital

    Beijing, 100071, China

  • Fudan University Shanghai Cancer Center

    Shanghai, 200032, China

  • Fujian Province Oncology Hospital

    Fuzhou, Fujian, 350014, China

  • Gaoxin Hospital of The First Affilated Hospital of Anhui Medical University

    Hefei, Anhui, 230088, China

  • General Hospital of Eastern Theater Command

    Nanjing, China

  • Guangdong Provincial People's Hospital

    Guangzhou, 510000, China

  • Harbin Medical University Cancer Hospital

    Harbin, Heilongjiang, 150081, China

  • Hunan Provincial Tumor Hospital/Division of Oncology

    Changsha, Hunan, 410013, China

  • Jilin Provincial Cancer Hospital

    Changchun, Jilin, 130103, China

  • Shanghai Chest Hospital

    Shanghai, 200030, China

  • Sichuan Province Cancer Hospital/Department of Pulmonary Tumor

    Chengdu, Sichuan, 610041, China

  • Sir Run Run Shaw Hospital of College of Medicine of Zhejiang University, Center for Oncology

    Hangzhou, Zhejiang, 310016, China

  • Tangdu Hospital of Fourth Military Medical University

    Xi’an, Shanxi, 710000, China

  • The First Affiliated Hospital Zhejiang University School of Medicine

    Hangzhou, 310003, China

  • The Second Affiliated Hospital of Zhejiang University College of Medicine

    Hangzhou, Zhejiang, 310009, China

  • The first hospital of jilin university

    Changchun, Jilin, 130021, China

  • West China Hospital, Sichuan University, Cancer center

    Chengdu, Sichuan, 610041, China

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang, 310022, China

  • Zhongshan Hospital, Fudan University

    Shanghai, 200032, China

Conditions

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