Drug trial aims to tame severe seizures in rare epilepsy
NCT ID NCT04572243
Summary
This study tested whether adding the drug lorcaserin to existing medications could better control convulsive seizures in people with Dravet syndrome, a rare and severe form of childhood epilepsy. It was a Phase 3 trial that enrolled 22 participants, comparing lorcaserin to a placebo (inactive pill) to see which was more effective at reducing seizure frequency. The trial was terminated early, and its main goal was to see if lorcaserin led to a greater percentage reduction in seizures over a 14-week period.
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Contacts and locations
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Locations
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Alberta Children's Hospital
Calgary, Alberta, AB T3B 6A8, Canada
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BC Children's Hospital
Vancouver, British Columbia, V6H 3N1, Canada
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Children's Hospital - VH, London Health Sciences Centre
London, Ontario, N6A 4G5, Canada
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, 15224, United States
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Children's of Alabama / University of Alabama at Birmingham
Birmingham, Alabama, 35226, United States
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Duke University Hospital Center
Durham, North Carolina, 27710, United States
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Institute of Neurology and Neurosurgery at Saint Barnabas
Livingston, New Jersey, 07039, United States
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Joe DiMaggio Children's Hospital
Hollywood, Florida, 33021, United States
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Miami Children's Hospital - Nicklaus Children's Hospital
Miami, Florida, 33155, United States
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Mid-Atlantic Epilepsy and Sleep Center - Bethesda
Bethesda, Maryland, 20817, United States
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MultiCare Institute for Research & Innovation
Tacoma, Washington, 98405, United States
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NYU Langone Comprehensive Epilepsy Center
New York, New York, 10016, United States
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New York Medical College
New York, New York, 10019-1147, United States
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NorthWell Health - Lennox Hill Hospital
New York, New York, 11021, United States
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Northwell Health - Neuroscience Institute at Great Neck
New Hyde Park, New York, 10075, United States
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Northwest Florida Clinical Research Group
Gulf Breeze, Florida, 32561, United States
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Pediatric Neurology, P.A.
Winter Park, Florida, 32789, United States
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Rare Disease Research Center Pediatrics, LLC
Atlanta, Georgia, 30318, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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Spectrum Health/ Helen DeVos Children's Hospital
Grand Rapids, Michigan, 49503, United States
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Stollery Children's Hospital
Edmonton, Alberta, T6G 1C9, Canada
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The University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States
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UCSD Rady's Children's Hosptial
San Diego, California, 92123, United States
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University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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University of California Los Angeles (UCLA)
Los Angeles, California, 90095, United States
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University of Missouri, Department of Child Health, Division of Neurology
Columbia, Missouri, 65201, United States
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University of North Carolina
Chapel Hill, North Carolina, 27599-7025, United States
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University of Rochester Medical Center
Rochester, New York, 14642, United States
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University of Toronto Division of Hematology Oncology/The Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
Conditions
Explore the condition pages connected to this study.