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New hope for PMR patients: Long-Term safety trial of secukinumab underway

NCT ID NCT06331312

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing the long-term safety of secukinumab, a biologic drug, in people with polymyalgia rheumatica (PMR). It includes 161 patients who already completed a 52-week study of secukinumab and had a relapse after stopping treatment. The main goal is to see how safe and tolerable the drug is over an extended period.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

secukinumab (a biologic drug given as an injection under the skin)

What this could lead to

If successful, this could show that secukinumab is a safe long-term treatment option for managing polymyalgia rheumatica, reducing the need for steroids.

What could go wrong

This is an extension study focused on safety, not on proving how well the drug works. The results may not apply to all patients, and long-term use of biologics carries risks like infections.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

polymyalgia rheumatica

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POLYMYALGIA RHEUMATICA

Contacts and locations

Locations

  • Accurate Clinical Research Inc

    Houston, Texas, 77089, United States

  • Advanced Rheumatology of Houston

    Spring, Texas, 77382, United States

  • Arizona Arthritis and Rheumatology Associates PLLC

    Avondale, Arizona, 85392, United States

  • Center for Rheumatology Research

    West Hills, California, 91307, United States

  • Clinical Research Inst of MI

    Saint Clair Shores, Michigan, 48081, United States

  • Dartmouth Hitchcock Medical Center

    Lebanon, New Hampshire, 03756, United States

  • Klein and Associates

    Hagerstown, Maryland, 21740, United States

  • Millennium Clinical Trials

    Westlake Village, California, 91361, United States

  • Novartis Investigative Site

    Quilmes, Buenos Aires, B1878GEG, Argentina

  • Novartis Investigative Site

    Buenos Aires, C1055AAF, Argentina

  • Novartis Investigative Site

    Parramatta, New South Wales, 2150, Australia

  • Novartis Investigative Site

    Heidelberg Heights, Victoria, 3081, Australia

  • Novartis Investigative Site

    Liège, 4000, Belgium

  • Novartis Investigative Site

    Porto Alegre, Rio Grande do Sul, 90480-000, Brazil

  • Novartis Investigative Site

    São Paulo, São Paulo, 04038-002, Brazil

  • Novartis Investigative Site

    São Paulo, 01409-902, Brazil

  • Novartis Investigative Site

    Québec, Quebec, G1V 3M7, Canada

  • Novartis Investigative Site

    Santiago, Santiago Metropolitan, 7500571, Chile

  • Novartis Investigative Site

    Santiago, Santiago Metropolitan, 8420383, Chile

  • Novartis Investigative Site

    Viña del Mar, Valparaiso, 2531172, Chile

  • Novartis Investigative Site

    Bogota, Cundinamarca, 110221, Colombia

  • Novartis Investigative Site

    Prague, Czech Republic, 140 00, Czechia

  • Novartis Investigative Site

    Brno, 638 00, Czechia

  • Novartis Investigative Site

    Hlučín, 748 01, Czechia

  • Novartis Investigative Site

    Prague, 128 00, Czechia

  • Novartis Investigative Site

    Prague, 140 00, Czechia

  • Novartis Investigative Site

    Uherské Hradiště, 686 01, Czechia

  • Novartis Investigative Site

    Esbjerg, 6700, Denmark

  • Novartis Investigative Site

    Gandrup, 9362, Denmark

  • Novartis Investigative Site

    Vejle, DK-7100, Denmark

  • Novartis Investigative Site

    Toulon, Val De Marne, 83800, France

  • Novartis Investigative Site

    Brest, 29200, France

  • Novartis Investigative Site

    Colmar, 68024, France

  • Novartis Investigative Site

    Dijon, 21000, France

  • Novartis Investigative Site

    Reims, 51092, France

  • Novartis Investigative Site

    Strasbourg, 67000, France

  • Novartis Investigative Site

    Toulouse, 31059, France

  • Novartis Investigative Site

    Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany

  • Novartis Investigative Site

    Würzburg, Bavaria, 97080, Germany

  • Novartis Investigative Site

    Berlin, 13125, Germany

  • Novartis Investigative Site

    Berlin, 13353, Germany

  • Novartis Investigative Site

    Herne, 44649, Germany

  • Novartis Investigative Site

    Budapest, 1027, Hungary

  • Novartis Investigative Site

    Szeged, 6725, Hungary

  • Novartis Investigative Site

    Veszprém, 8200, Hungary

  • Novartis Investigative Site

    Bolzano, BZ, 39100, Italy

  • Novartis Investigative Site

    Milan, MI, 20100, Italy

  • Novartis Investigative Site

    Perugia, PG, 06129, Italy

  • Novartis Investigative Site

    Fukuoka, Fukuoka, 8140180, Japan

  • Novartis Investigative Site

    Asahikawa, Hokkaido, 0708644, Japan

  • Novartis Investigative Site

    Kita-gun, Kagawa-ken, 7610793, Japan

  • Novartis Investigative Site

    Sagamihara, Kanagawa, 2520392, Japan

  • Novartis Investigative Site

    Yokohama, Kanagawa, 222-0036, Japan

  • Novartis Investigative Site

    Nagano, Nagano, 3808582, Japan

  • Novartis Investigative Site

    Kawachi-Nagano, Osaka, 5868521, Japan

  • Novartis Investigative Site

    Bunkyo Ku, Tokyo, 1138431, Japan

  • Novartis Investigative Site

    Fuchū, Tokyo, 1838524, Japan

  • Novartis Investigative Site

    Ōme, Tokyo, 198-0042, Japan

  • Novartis Investigative Site

    Chūō, Yamanashi, 409-3898, Japan

  • Novartis Investigative Site

    Okayama, 700-8607, Japan

  • Novartis Investigative Site

    Osaka, 5340021, Japan

  • Novartis Investigative Site

    Guadalajara, Jalisco, 44650, Mexico

  • Novartis Investigative Site

    Almelo, Overijssel, 7609 PP, Netherlands

  • Novartis Investigative Site

    Rotterdam, South Holland, 3079 DZ, Netherlands

  • Novartis Investigative Site

    Lublin, 20-607, Poland

  • Novartis Investigative Site

    Warsaw, 02-118, Poland

  • Novartis Investigative Site

    Warsaw, 02-665, Poland

  • Novartis Investigative Site

    Cape Town, Western Cape, 7405, South Africa

  • Novartis Investigative Site

    Cape Town, Western Cape, 7500, South Africa

  • Novartis Investigative Site

    Sabadell, Barcelona, 08208, Spain

  • Novartis Investigative Site

    Bilbao, Bizkaia, 48013, Spain

  • Novartis Investigative Site

    A Coruña, 15006, Spain

  • Novartis Investigative Site

    Madrid, 28009, Spain

  • Novartis Investigative Site

    Seville, 41013, Spain

  • Novartis Investigative Site

    Valencia, 46010, Spain

  • Novartis Investigative Site

    Sankt Gallen, 9007, Switzerland

  • Novartis Investigative Site

    Barnet, EN5 3DJ, United Kingdom

  • Novartis Investigative Site

    Wolverhampton, WV10 0QP, United Kingdom

  • Paramount Med Rsrch and Consult LLC

    Middleburg Heights, Ohio, 44130, United States

  • Prolato Clinical Research Center

    Houston, Texas, 77054, United States

  • Rheumatology Associates of South Florida

    Boca Raton, Florida, 33486, United States

  • Sun Valley Arthritis Center Ltd

    Peoria, Arizona, 85381, United States

  • West Broward Rheumatology Associates Inc

    Tamarac, Florida, 33321, United States