Cushing's drug osilodrostat under Long-Term safety review
NCT ID NCT05382156
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study follows 206 patients with Cushing's syndrome who are taking osilodrostat (Isturisa) to see how safe and effective it is over time. Researchers will track side effects and how well the drug controls cortisol levels. No new treatment is given—just real-world monitoring.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Osilodrostat (Isturisa), a drug that lowers cortisol levels
- What this could lead to
- If successful, this study will confirm that osilodrostat is safe and effective for long-term control of Cushing's syndrome, helping doctors manage the disease better.
- What could go wrong
- This is an observational study, not a controlled trial, so results may be less reliable. It only includes patients already on the drug, so it cannot prove cause and effect.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Amedes Experts
Hamburg, 20095, Germany
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Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
Roma, 00189, Italy
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Azienda Ospedaliera Universitaria "Federico II"
Naples, 80131, Italy
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Azienda Ospedaliero Universitaria Ospedali Riuniti
Ancona, 60126, Italy
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Barrow Neurological Institute
Phoenix, Arizona, 85013, United States
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CHU de Grenoble site Nord
Grenoble, 38043, France
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CHU de Nantes-Hopital Laennec
Nantes, 44800, France
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Charité Universitaetsmedizin Berlin
Berlin, 10117, Germany
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Emory University School
Atlanta, Georgia, 30322, United States
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Endocrinology Research Associates, Inc.
Columbus, Ohio, 43201, United States
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Endokrinologikum Frankfurt
Frankfurt, 60596, Germany
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Erasmus MC
Rotterdam, 3015 GD, Netherlands
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Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Froedtert Hospital
Milwaukee, Wisconsin, 53226, United States
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Groupement Hospitalier Sud - Hôpital Bicêtre
Le Kremlin-Bicêtre, 94275, France
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Hopital Claude Huriez - CHRU Lille
Lille, 59037, France
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Hopital Larrey
Toulouse, 31000, France
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Hopital de la Conception - APHM
Marseille, 13005, France
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Hospices Civiles de Lyon
Bron, 69677, France
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Hôpital Cochin
Paris, 75679, France
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Hôpital Haut-Lévêque
Bordeaux, 33604, France
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Hôpital de Brabois
Nancy, 54500, France
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Indiana University Schl-med
Indianapolis, Indiana, 46202, United States
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Ludwig-Maximilians University of Munich
Munich, Germany
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Massachusetts General Hospital
Boston, Massachusetts, 02114-2696, United States
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Mayo Clinic - Rochester
Rochester, Minnesota, 55905, United States
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Medicover Berlin-Mitte MVZ
Berlin, 10117, Germany
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Medicover Köln
Cologne, 50939, Germany
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Medicover MVZ Oldenburg
Oldenburg, 26122, Germany
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Medicover Neuroendokrinologie
Munich, 81667, Germany
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Memorial Sloan-Kettering Cancer Center (MSKCC) - New York
New York, New York, 10021, United States
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NYU Grossman School of Medicine
New York, New York, 10017, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Oregon Health And Science University
Portland, Oregon, 97239, United States
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Policlinico Umberto I
Roma, 00186, Italy
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Radboud University Nijmegen
Nijmegen, 6500, Netherlands
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St Elizabeth Physicians
Covington, Kentucky, 41011, United States
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Universitaet Bielefeld - Klinikum Bielefeld - Mitte
Düsseldorf, Germany
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Universitaetsklinikum Frankfurt Goethe-Universitaet
Frankfurt, 60590, Germany
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Universitaetsklinikum Wuerzburg
Würzburg, 97080, Germany
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of Pennsylvania Medical Center
Philadelphia, Pennsylvania, 19104, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States