New drug combo tested for long-term safety in teens with schizophrenia and kids with autism irritability
NCT ID NCT07424404
First seen Feb 24, 2026 · Last updated May 13, 2026 · Updated 15 times
Summary
This study checks the long-term safety of KarXT in teens (13-17) with schizophrenia and KarXT plus KarX-EC in children (5-17) with irritability linked to autism. About 400 participants who completed earlier studies will take the drug for up to 2 years. Researchers will monitor side effects, including serious ones, and track changes in symptoms and behavior.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Apg Research, Llc
RECRUITINGOrlando, Florida, 32803, United States
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Atlanta Center for Medical Research
RECRUITINGAtlanta, Georgia, 30331, United States
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EmVenio Research Center - Prime Healthcare
RECRUITINGChicago, Illinois, 60622, United States
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Goryokai Medical Corporation - Goryokai Hospital
RECRUITINGSapporo, Hokkaido, 002-8029, Japan
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Local Institution - 0008
NOT_YET_RECRUITINGIași, 700282, Romania
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Local Institution - 0024
NOT_YET_RECRUITINGCulver City, California, 90230, United States
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Local Institution - 0025
NOT_YET_RECRUITINGZentsujichó, Kagawa-ken, 765-8507, Japan
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Local Institution - 0029
NOT_YET_RECRUITINGBucharest, Bucharest, 041914, Romania
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Local Institution - 0031
NOT_YET_RECRUITINGCluj-Napoca, Cluj, 400370, Romania
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Local Institution - 0035
NOT_YET_RECRUITINGCórdoba, X5003DCE, Argentina
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Local Institution - 0036
NOT_YET_RECRUITINGBuenos Aires, C1405BOA, Argentina
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Local Institution - 0038
NOT_YET_RECRUITINGTimișoara, 300011, Romania
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Local Institution - 0039
NOT_YET_RECRUITINGStone Mountain, Georgia, 30083, United States
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Local Institution - 0040
NOT_YET_RECRUITINGBucharest, 021056, Romania
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Local Institution - 0042
NOT_YET_RECRUITINGBucharest, 031871, Romania
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Local Institution - 0046
NOT_YET_RECRUITINGGarland, Texas, 75043, United States
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Local Institution - 0050
NOT_YET_RECRUITINGRichmond, Virginia, 23284, United States
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Local Institution - 0056
NOT_YET_RECRUITINGŌta-ku, Tokyo, 143-8541, Japan
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Local Institution - 0058
NOT_YET_RECRUITINGChino, California, 91710, United States
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Local Institution - 0059
NOT_YET_RECRUITINGWorcester, Massachusetts, 01608, United States
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Local Institution - 0061
NOT_YET_RECRUITINGGreat Neck, New York, 11021, United States
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Local Institution - 0062
NOT_YET_RECRUITINGMiyakonojō, Miyazaki, 885-0093, Japan
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Local Institution - 0063
NOT_YET_RECRUITINGYokohama, Kanagawa, 213-8507, Japan
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Local Institution - 0066
NOT_YET_RECRUITINGSpring, Texas, 77381, United States
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Local Institution - 0075
NOT_YET_RECRUITINGChikugo, Fukuoka, 833-0041, Japan
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Local Institution - 0076
NOT_YET_RECRUITINGBoston, Massachusetts, 02115, United States
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NOT_YET_RECRUITINGAnaheim, California, 92805, United States
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NOT_YET_RECRUITINGRedlands, California, 92373, United States
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Local Institution - 0084
NOT_YET_RECRUITINGCiudad Autónoma de Buenos Aires, Buenos Aires, C1107, Argentina
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Local Institution - 0085
NOT_YET_RECRUITINGLa Plata, Buenos Aires, 1900, Argentina
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Local Institution - 0086
NOT_YET_RECRUITINGBunkyo-ku, Tokyo, 113-8431, Japan
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Local Institution - 0089
NOT_YET_RECRUITINGSan Francisco, California, 94158, United States
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Local Institution - 0097
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19139, United States
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NOT_YET_RECRUITINGMadrid, 28007, Spain
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NOT_YET_RECRUITINGBarcelona, 8035, Spain
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Local Institution - 0100
NOT_YET_RECRUITINGMadrid, 28031, Spain
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Local Institution - 0101
NOT_YET_RECRUITINGBarcelona, 08036, Spain
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Local Institution - 0110
NOT_YET_RECRUITINGKingston, Ontario, K7L4X3, Canada
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Local Institution - 0111
NOT_YET_RECRUITINGEdmonton, Alberta, T6G 1Z1, Canada
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NOT_YET_RECRUITINGMontreal, Quebec, H3T 1C5, Canada
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Local Institution - 0113
NOT_YET_RECRUITINGToronto, Ontario, M4G 1R8, Canada
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Local Institution - 0116
NOT_YET_RECRUITINGSantiago del Estero, G4200DND, Argentina
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Local Institution - 0118
NOT_YET_RECRUITINGBordeaux, 33076, France
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Local Institution - 0119
NOT_YET_RECRUITINGParis, 75019, France
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Local Institution - 0120
NOT_YET_RECRUITINGBron, 69678, France
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Local Institution - 0121
NOT_YET_RECRUITINGGdansk, 80-546, Germany
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Local Institution - 0122
NOT_YET_RECRUITINGKraśnik, Lublin Voivodeship, 23-210, Poland
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Local Institution - 0123
NOT_YET_RECRUITINGSzczecin, West Pomeranian Voivodeship, 70-419, Poland
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Local Institution - 0124
NOT_YET_RECRUITINGKatowice, 40-146, Poland
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NOT_YET_RECRUITINGWroclaw, Lower Silesian Voivodeship, 54-234, Poland
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Local Institution - 0126
NOT_YET_RECRUITINGGdansk, Pomeranian Voivodeship, 80-542, Poland
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Local Institution - 0127
NOT_YET_RECRUITINGWarsaw, Masovian Voivodeship, 02-957, Poland
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Local Institution - 0128
NOT_YET_RECRUITINGPoznan, Greater Poland Voivodeship, 60-744, Poland
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Local Institution - 0129
NOT_YET_RECRUITINGBudapest, 1143, Hungary
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Local Institution - 0130
NOT_YET_RECRUITINGGyula, 5700, Hungary
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Local Institution - 0131
NOT_YET_RECRUITINGSzeged, 6720, Hungary
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Local Institution - 0137
NOT_YET_RECRUITINGNashville, Tennessee, 37212, United States
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Salveo Integrative Health - Lawrenceville
RECRUITINGLawrenceville, Georgia, 30046, United States
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University of Cincinnati Cancer Institute
RECRUITINGCincinnati, Ohio, 45219, United States
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