15-Year study tracks hidden risks of CAR-T cancer therapy

NCT ID NCT02445222

Recruiting now Knowledge-focused Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 1,400 people who previously received CAR-T cell therapy for cancer. Researchers will monitor them for 15 years to check for delayed side effects like new cancers, infections, or immune disorders. The goal is to understand the long-term safety of this gene-based treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lentiviral-based CAR-T cell therapy
What this could lead to: If successful, this study will confirm the long-term safety of CAR-T therapy, helping doctors better understand risks and benefits for future patients.
What could go wrong: This is a follow-up study, not a treatment trial, so it won't directly help participants. It may find rare or unexpected side effects over 15 years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LONG TERM SAFETY OF PATIENTS RECEIVING CAR-T IN AN ELIGIBLE CLINICAL TRIAL OR MANAGED ACCESS PROGRAM

Contacts and locations

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Locations

Beth Israel Deaconess Med Center
RECRUITING

Boston, Massachusetts, 02215, United States
Children s Mercy Hospital
RECRUITING

Kansas City, Missouri, 64108, United States
Children's Mercy Hospital SC
RECRUITING

Kansas City, Missouri, 64108, United States
Childrens Healthcare of Atlanta
RECRUITING

Atlanta, Georgia, 30342, United States
Childrens Hospital Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229-3039, United States
Cinn Children Hosp Medical Center
RECRUITING

Cincinnati, Ohio, 45229-3039, United States
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010 3000, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duke Unversity Medical Center
RECRUITING

Durham, North Carolina, 27705, United States
Duke Unversity Medical Center SC - CTL019B2205J
RECRUITING

Durham, North Carolina, 27705, United States
Emory University School of Medicine-Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Emory University School of Medicine/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
MD Anderson Cancer Center SC
RECRUITING

Houston, Texas, 77030, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic Arizona
COMPLETED

Phoenix, Arizona, 85054, United States
Novartis Investigative Site
RECRUITING

Camperdown, New South Wales, 2050, Australia
Novartis Investigative Site
RECRUITING

Melbourne, Victoria, 3000, Australia
Novartis Investigative Site
RECRUITING

Melbourne, Victoria, 3004, Australia
Novartis Investigative Site
WITHDRAWN

Parkville, Victoria, 3052, Australia
Novartis Investigative Site
RECRUITING

Murdoch, Western Australia, 6150, Australia
Novartis Investigative Site
RECRUITING

Herston, QLD 4006, Australia
Novartis Investigative Site
WITHDRAWN

Linz, 4020, Austria
Novartis Investigative Site
RECRUITING

Salzburg, 5020, Austria
Novartis Investigative Site
RECRUITING

Vienna, 1090, Austria
Novartis Investigative Site
RECRUITING

Vienna, A 1090, Austria
Novartis Investigative Site
RECRUITING

Ghent, 9000, Belgium
Novartis Investigative Site
RECRUITING

Hamilton, Ontario, L8V 1C3, Canada
Novartis Investigative Site
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Toronto, Ontario, M5G 1X8, Canada
Novartis Investigative Site
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Novartis Investigative Site
RECRUITING

Montreal, Quebec, H3T 1C5, Canada
Novartis Investigative Site
RECRUITING

Beijing, 100036, China
Novartis Investigative Site
RECRUITING

Copenhagen, DK-2100, Denmark
Novartis Investigative Site
RECRUITING

Helsinki, 00029, Finland
Novartis Investigative Site
RECRUITING

Nantes, 44093, France
Novartis Investigative Site
RECRUITING

Paris, 75019, France
Novartis Investigative Site
RECRUITING

Paris, 75475, France
Novartis Investigative Site
RECRUITING

Pierre-Bénite, 69495, France
Novartis Investigative Site
RECRUITING

Villejuif, 94800, France
Novartis Investigative Site
RECRUITING

Munich, Bavaria, 81377, Germany
Novartis Investigative Site
RECRUITING

Regensburg, Bavaria, 93053, Germany
Novartis Investigative Site
RECRUITING

Würzburg, Bavaria, 97080, Germany
Novartis Investigative Site
RECRUITING

Frankfurt am Main, Hesse, 60590, Germany
Novartis Investigative Site
RECRUITING

Cologne, North Rhine-Westphalia, 50937, Germany
Novartis Investigative Site
RECRUITING

Leipzig, Saxony, 04103, Germany
Novartis Investigative Site
RECRUITING

Berlin, 13353, Germany
Novartis Investigative Site
RECRUITING

Hamburg, 20246, Germany
Novartis Investigative Site
RECRUITING

Ulm, 89081, Germany
Novartis Investigative Site
RECRUITING

Chaïdári, 124 62, Greece
Novartis Investigative Site
RECRUITING

Hong Kong, Hong Kong
Novartis Investigative Site
RECRUITING

Ramat Gan, 5265601, Israel
Novartis Investigative Site
RECRUITING

Tel Aviv, 6423906, Israel
Novartis Investigative Site
RECRUITING

Bologna, BO, 40138, Italy
Novartis Investigative Site
RECRUITING

Monza, MB, 20900, Italy
Novartis Investigative Site
RECRUITING

Milan, MI, 20132, Italy
Novartis Investigative Site
RECRUITING

Milan, MI, 20133, Italy
Novartis Investigative Site
RECRUITING

Rozzano, MI, 20089, Italy
Novartis Investigative Site
RECRUITING

Roma, RM, 00165, Italy
Novartis Investigative Site
RECRUITING

Roma, RM, 00168, Italy
Novartis Investigative Site
RECRUITING

Fukuoka, Fukuoka, 812-8582, Japan
Novartis Investigative Site
RECRUITING

Sapporo, Hokkaido, 060 8648, Japan
Novartis Investigative Site
RECRUITING

Sendai, Miyagi, 980 8574, Japan
Novartis Investigative Site
WITHDRAWN

Chuo Ku, Tokyo, 104 0045, Japan
Novartis Investigative Site
RECRUITING

Kyoto, 606 8507, Japan
Novartis Investigative Site
COMPLETED

Amsterdam, North Holland, 1105 AZ, Netherlands
Novartis Investigative Site
COMPLETED

Utrecht, 3584 CS, Netherlands
Novartis Investigative Site
WITHDRAWN

Utrecht, 3584 CX, Netherlands
Novartis Investigative Site
RECRUITING

Oslo, 0310, Norway
Novartis Investigative Site
RECRUITING

Oslo, 0424, Norway
Novartis Investigative Site
RECRUITING

Riyadh, 11211, Saudi Arabia
Novartis Investigative Site
RECRUITING

Singapore, 119074, Singapore
Novartis Investigative Site
RECRUITING

Singapore, 169608, Singapore
Novartis Investigative Site
RECRUITING

Seoul, 03080, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 03722, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 05505, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 06351, South Korea
Novartis Investigative Site
RECRUITING

Esplugues, Barcelona, 08950, Spain
Novartis Investigative Site
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Novartis Investigative Site
RECRUITING

Salamanca, Castille and León, 37007, Spain
Novartis Investigative Site
RECRUITING

Barcelona, Catalonia, 08035, Spain
Novartis Investigative Site
RECRUITING

Pamplona, Navarre, 31008, Spain
Novartis Investigative Site
RECRUITING

Barcelona, 08041, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28009, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28041, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28046, Spain
Novartis Investigative Site
RECRUITING

Seville, 41013, Spain
Novartis Investigative Site
RECRUITING

Valencia, 46010, Spain
Novartis Investigative Site
RECRUITING

Taipei, 10002, Taiwan
Novartis Investigative Site
RECRUITING

Birmingham, B15 2TH, United Kingdom
Novartis Investigative Site
RECRUITING

London, SE5 9RS, United Kingdom
Ohio ST Compr Cancer Ctr James Hosp
RECRUITING

Columbus, Ohio, 43210, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Oregon Health Sciences University
RECRUITING

Portland, Oregon, 97239, United States
Sarah Cannon Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States
Stanford University Medical Center
RECRUITING

Stanford, California, 94304, United States
The Childrens Hosp of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UCLA Medical Center
RECRUITING

Los Angeles, California, 90095, United States
UCSF Medical Center
RECRUITING

San Francisco, California, 94143, United States
UTSW/Children's Medical Center
RECRUITING

Dallas, Texas, 75235, United States
Uni Of Michigan Health System
RECRUITING

Ann Arbor, Michigan, 48109, United States
Uni of Chi Medi Ctr Hema and Onco
RECRUITING

Chicago, Illinois, 60637, United States
University of Chicago Medical Center, Hematology & Oncology
RECRUITING

Chicago, Illinois, 60637, United States
University of Kansas Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Kansas Cancer Center SC
RECRUITING

Westwood, Kansas, 66205, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109-2800, United States
University of Michigan Health System SC CTL019
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota
WITHDRAWN

Minneapolis, Minnesota, 55455, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Utah Clinical Trials Office
RECRUITING

Salt Lake City, Utah, 84108, United States
University of Utah Clinical Trials Office
RECRUITING

Salt Lake City, Utah, 84108, United States
University of Wisconsin Hospital
RECRUITING

Madison, Wisconsin, 53792, United States
University of Wisconsin Hospital and Clinics
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Email: •••••@•••••
Wayne State University-Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Weill Cornell Medical College
WITHDRAWN

New York, New York, 10065, United States