Heart drug gets 3-Year safety check in major patient study

NCT ID NCT05667493

Summary

This study aims to check the long-term safety of a medication called eplontersen for people with a serious heart condition called ATTR-CM. About 1,400 patients who completed a previous study will receive the drug by injection every 4 weeks for up to 3 years. Researchers will monitor for side effects and see how the treatment affects patients' heart function and quality of life over time.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A Beneficência Portuguesa de São Paulo - Unidade Mirante

    São Paulo, 01323-030, Brazil

  • AES - Synexus - Midlands

    Edgbaston, England, B15 2SQ, United Kingdom

  • AES - Synexus - Scotland Clinical Research Centre

    Bellshill, England, ML4 3NJ, United Kingdom

  • AES - Synexus - Wales

    Cardiff, Wales, CF15 9SS, United Kingdom

  • Advara HeartCare

    Joondalup, Western Australia, 6027, Australia

  • Advara HeartCare - Joondalup

    Joondalup, 6027, Australia

  • Advara HeartCare Murdoch

    Murdoch, Western Australia, 6150, Australia

  • Advara HeartCare Murdoch

    Murdoch, 6150, Australia

  • Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan

    Bruges, 8000, Belgium

  • Allina Health Minneapolis Heart Institute - Abbott Northwestern's Heart Hospital

    Minneapolis, Minnesota, 55407, United States

  • Altman Clinical and Translational Research Institute - Center for Clinical Research

    La Jolla, California, 92037, United States

  • Azienda Ospedale Università di Padova

    Padua, 35128, Italy

  • Azienda Ospedaliera - Universitaria Sant' Andrea

    Roma, 00189, Italy

  • Azienda Ospedaliero - Universitaria Careggi

    Florence, 50134, Italy

  • Azienda Ospedaliero Universitaria Delle Marche

    Ancona, 60126, Italy

  • Barnes-Jewish Hospital

    St Louis, Missouri, 63110, United States

  • Boston University School of Medicine

    Boston, Massachusetts, 02118, United States

  • Box Hill Hospital

    Clayton, 3168, Australia

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Carl and Edyth Lindner Research Center at The Christ Hospital

    Cincinnati, Ohio, 45219, United States

  • Cedars-Sinai Medical Center

    Beverly Hills, California, 90211, United States

  • Centre Hospitalier Départemental Vendée

    La Roche-sur-Yon, 85925, France

  • Centre Hospitalier Universitaire De Nantes - Hôpital Nord Laennec

    Nantes, 44093, France

  • Centre Hospitalier de l'Université de Montréal (CHUM)

    Montreal, Quebec, H2X 0C1, Canada

  • Centro Avançado de Pesquisa e Estudos para o Diagnóstico CAPED

    São Paulo, 14026-900, Brazil

  • Centro Hospitalar Universitário de São João

    Porto, 4200-319, Portugal

  • Centro Hospitalar Universitário do Porto - Hospital Geral de Santo Antonio

    Porto, 4099-001, Portugal

  • Cleveland Clinic Florida

    Weston, Florida, 33331, United States

  • Cleveland Clinic Main Campus

    Cleveland, Ohio, 44195, United States

  • Columbia University Irving Medical Center

    New York, New York, 10034, United States

  • Complejo Hospitalario Universitario de Santiago (CHUS)

    Santiago de Compostela, 15706, Spain

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Emory Heart and Vascular Center - Emory Clifton Campus

    Atlanta, Georgia, 30322, United States

  • Fakultní Nemocnice u sv. Anny v Brně

    Brno, 656 91, Czechia

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100, Italy

  • Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanita Pubblica

    Pisa, 56124, Italy

  • General Hospital of Athens "Alexandra"

    Athens, 115 28, Greece

  • Gordon and Leslie Diamond Health Care Centre

    Vancouver, V5Z 1M9, Canada

  • Hadassah University Hospital Ein Kerem

    Jerusalem, 9112001, Israel

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

  • Hospital Clínico Universitario Virgen de la Arrixaca

    Murcia, 30120, Spain

  • Hospital Italiano de Buenos Aires

    Buenos Aires, C1199ABB, Argentina

  • Hospital Moinhos de Vento

    Porto Alegre, 90560-030, Brazil

  • Hospital Universitari Vall d'Hebrón

    Barcelona, 08035, Spain

  • Hospital Universitario Puerta de Hierro

    Majadahonda, 28222, Spain

  • Hospital da Senhora da Oliveira

    Guimarães, 4835-044, Portugal

  • Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto

    Ribeirão Preto, 14040-030, Brazil

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Hôpital Haut-Lévêque

    Pessac, 33604, France

  • Hôpital Rangueil

    Toulouse, 31059, France

  • Hôpital Regional de Rimouski

    Rimouski, G5L 5T1, Canada

  • Hôpital de la Timone

    Marseille, 13005, France

  • Hôpitaux Universitaires Henri Mondor

    Créteil, 94010, France

  • Indiana University Health University Hospital

    Indianapolis, Indiana, 46202, United States

  • Institut Klinické a Experimentální Medicíny

    Prague, 140 21, Czechia

  • Instituto Cardiovascular de Buenos Aires

    Buenos Aires, C1428ART, Argentina

  • Instituto Dante Pazzanese de Cardiologia

    São Paulo, 04012-909, Brazil

  • Instituto do Coração de São Paulo

    São Paulo, 05403-000, Brazil

  • Kaplan Medical Center

    Rehovot, 7661041, Israel

  • Krakowski Szpital Specjalistyczny im. Jana Pawła II

    Krakow, 31- 202, Poland

  • Kumamoto University Hospital

    Kumamoto, 860-8556, Japan

  • Kurume University Hospital

    Kurume-Shi, Fukuoka, 830-0011, Japan

  • Lancaster General Hospital

    Lancaster, Pennsylvania, 17602, United States

  • Liverpool Hospital

    Liverpool, 2170, Australia

  • Loyola University Medical Center

    Maywood, Illinois, 60153, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic

    Scottsdale, Arizona, 85259, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Medizinische Universität Graz

    Graz, 8036, Austria

  • Medizinische Universität Innsbruck

    Innsbruck, 6020, Austria

  • Medizinische Universität Wien

    Vienna, 1090, Austria

  • New York University Langone Cardiology Associates

    New York, New York, 10016, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Penn Presbyterian Medical Center

    Philadelphia, Pennsylvania, 19104, United States

  • Piedmont Atlanta Hospital

    Fayetteville, Georgia, 30214, United States

  • Piedmont Heart of Fayetteville

    Atlanta, Georgia, 30309, United States

  • Princess Alexandra Hospital

    Woolloongabba, 4102, Australia

  • Rambam Health Care Campus

    Haifa, 3109601, Israel

  • Richmond Pharmacology

    London, SE1 1YR, United Kingdom

  • Rigshospitalet

    Copenhagen, 2100, Denmark

  • Royal Free London NHS Foundation Trust

    Hampstead, NW3 2PF, United Kingdom

  • Royal Hobart Hospital

    Hobart, 7000, Australia

  • Sahlgrenska Universitetssjukhuset

    Gothenburg, 413 45, Sweden

  • Saint Luke's Hospital of Kansas City

    Kansas City, Missouri, 64111, United States

  • Saiseikai Fukuoka General Hospital

    Fukuoka, Hukuoka [Fukuoka], 810-0001, Japan

  • Skellefteå lasarett

    Skellefteå, 931 86, Sweden

  • Stanford University (Leland Stanford Junior University)

    Stanford, California, 94305, United States

  • Synexus - Manchester Clinical Research Centre

    Manchester, England, M15 6SE, United Kingdom

  • The George Washington Medical Faculty Associates - Foggy Bottom North Pavilion

    Washington D.C., District of Columbia, 20037, United States

  • The Ohio State University College of Medicine

    Columbus, Ohio, 43210, United States

  • Unidade Local de Saúde de Santo António, E. P. E - Hospital Geral de Santo Antonio

    Porto, 4099-001, Portugal

  • Unidade Local de Saúde de São José, E. P. E - Hospital de Santa Marta

    Lisbon, 1169-024, Portugal

  • Unidade Local de Saúde de São João, EPE

    Porto, 4200-319, Portugal

  • Unidade Local de Saúde do Alto Ave, E. P. E (Hospital da Senhora da Oliveira Guimarães)

    Guimarães, 4835-044, Portugal

  • Uniklinik Köln

    Cologne, 50937, Germany

  • Universidade Estadual de Campinas

    São Paulo, 13083881, Brazil

  • Universitaetsklinikum Heidelberg - Zentrum für Innere Medizin

    Heidelberg, 69120, Germany

  • University Hospital - London Health Sciences Centre

    London, Ontario, N6A 5A5, Canada

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University Of California San Francisco Urology Practice

    San Francisco, California, 94143, United States

  • University of Calgary

    Calgary, Alberta, T2N 4Z6, Canada

  • University of Colorado Hospital - Anschutz Medical Campus

    Aurora, Colorado, 80045, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • University of Kansas Medical Center (KUMC)

    Kansas City, Kansas, 66160, United States

  • University of Maryland Medical Center

    Baltimore, Maryland, 21201, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • University of Utah

    Salt Lake City, Utah, 84112, United States

  • University of Washington

    Seattle, Washington, 98195, United States

  • University of Wisconsin - Madison

    Madison, Wisconsin, 53792, United States

  • Universitätsklinikum Münster

    Münster, 48149, Germany

  • Universitätsklinikum Würzburg

    Würzburg, 97078, Germany

  • Universitätsklinikum des Saarlandes

    Homburg, 66421, Germany

  • Vanderbilt Heart and Vascular Institute

    Nashville, Tennessee, 37232, United States

  • Virginia Commonwealth University

    Richmond, Virginia, 23298, United States

  • Vseobecna Fakultni Nemocnice v Praze

    Prague, 116 36, Czechia

  • Weill Cornell Medicine Cardiology

    New York, New York, 10021, United States

  • Westmead Hospital

    Westmead, 2145, Australia

  • Ziekenhuis Oost-Limburg - Campus Sint-Jan

    Limbourg, 3600, Belgium

Conditions

Explore the condition pages connected to this study.