Gene therapy for radiation dry mouth: long-term follow-up begins

NCT ID NCT06544798

ENROLLING_BY_INVITATION Disease control Sponsor: MeiraGTx, LLC Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 23 times

Summary

This study follows 276 adults who received a gene therapy (AAV2-hAQP1) for dry mouth caused by past radiation for head and neck cancers. The goal is to see if the treatment remains safe and effective over time. Participants must have already received the therapy in an earlier study.

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Contacts and locations

Locations

  • Alleghany General Hospital

    Pittsburgh, Pennsylvania, 15212, United States

  • Atrium Health

    Charlotte, North Carolina, 28209, United States

  • Banner MD Anderson Cancer Center

    Gilbert, Arizona, 85234, United States

  • Erie County Medical Center

    Buffalo, New York, 14215, United States

  • Miami Cancer Institute at Baptist Health South Florida

    Miami, Florida, 33176, United States

  • Shirley and Jim Fielding Northeast Cancer Centre - Health Sciences North

    Greater Sudbury, Ontario, P3E 5J1, Canada

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Missouri

    Columbia, Missouri, 65212, United States

Conditions

Explore the condition pages connected to this study.