Order of surgical steps may affect lung cancer survival

NCT ID NCT06577792

Ongoing Disease control Sponsor: Sun Yat-sen University Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This trial tests whether removing the lung tumor before the lymph nodes, or the lymph nodes before the tumor, leads to better long-term survival in people with early-stage non-small cell lung cancer. About 620 patients will be randomly assigned to one of the two sequences. The study tracks survival and complications over five years to determine the best approach.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: surgical procedure comparing lobectomy-first versus lymphadenectomy-first
What this could lead to: If one sequence proves better, it could become the standard surgical approach for early-stage lung cancer, potentially improving long-term survival.
What could go wrong: This is a mid-stage trial with 620 participants, so results may not apply to all patients. The difference between sequences might be small or not statistically significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

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Locations

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, 100021, China
Dongguan People's Hospital

Dongguan, Guangdong, 523059, China
First Affiliated Hospital of Jinan University

Guangzhou, Guangdong, 510632, China
First Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, 650032, China
First People's Hospital of Foshan

Foshan, Guangdong, 528000, China
Fujian Medical University Union Hospital

Fuzhou, Fujian, 350001, China
Fujian Provincial Hospital

Fuzhou, Fujian, 350001, China
Gansu Provincial Hospital

Lanzhou, Gansu, 730013, China
Jiangsu Cancer Institute & Hospital

Nanjing, Jiangsu, 210009, China
RenJi Hospital

Shanghai, Shanghai Municipality, 200001, China
Shandong Provincial Hospital

Jinan, Shandong, 250022, China
Shanghai Changzheng Hospital

Shanghai, Shanghai Municipality, 201209, China
Sichuan Cancer Hospital and Research Institute

Chengdu, Sichuan, 610041, China
Sixth Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, 510655, China
Suining Central Hospital

Suining, Sichuan, 629099, China
Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, 510060, China
Tang-Du Hospital

Xi'an, Shaanxi, 710032, China
The Affiliated Hospital of Qingdao University

Qingdao, Shandong, 266075, China
The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221132, China
The First Affiliated Hospital with Nanjing Medical University

Nanjing, Jiangsu, 210029, China
The General Hospital of Eastern Theater Command

Nanjing, Jiangsu, 210016, China
Tianjin Chest Hospital

Tianjin, Tianjin Municipality, 300222, China
Tianjin Medical University Cancer Institute and Hospital

Tianjin, Tianjin Municipality, 300060, China
West China Hospital

Chengdu, Sichuan, 610041, China
Wuhan TongJi Hospital

Wuhan, Hubei, 430014, China
Wuhan Union Hospital, China

Wuhan, Hubei, 430090, China

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