Breakthrough drug trial aims to reverse liver scarring in advanced disease

NCT ID NCT06419374

Recruiting now Disease control Sponsor: 89bio, Inc. Source: ClinicalTrials.gov ↗

Summary

This study is testing whether an investigational drug called pegozafermin can reduce liver scarring in people with advanced MASH-related cirrhosis. Researchers will enroll 762 adults with confirmed liver scarring but without liver failure to receive either the drug or placebo for 24 months. The main goal is to see if the treatment can improve liver scarring and prevent serious liver complications.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

89bio Clinical Study Site
RECRUITING

Birmingham, Alabama, 35205, United States

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89bio Clinical Study Site
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Homewood, Alabama, 35209, United States

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89bio Clinical Study Site
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Chandler, Arizona, 85224, United States

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89bio Clinical Study Site
WITHDRAWN

Flagstaff, Arizona, 86001, United States
89bio Clinical Study Site
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Peoria, Arizona, 85381, United States

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Phoenix, Arizona, 85054, United States

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Tucson, Arizona, 85712, United States

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Tucson, Arizona, 85715, United States

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89bio Clinical Study Site
RECRUITING

Tucson, Arizona, 85716, United States

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89bio Clinical Study Site
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Little Rock, Arkansas, 72205, United States

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89bio Clinical Study Site
RECRUITING

North Little Rock, Arkansas, 72117, United States

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89bio Clinical Study Site
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Camarillo, California, 93012, United States

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89bio Clinical Study Site
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Canoga Park, California, 91304, United States

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89bio Clinical Study Site
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Coronado, California, 92118, United States

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89bio Clinical Study Site
RECRUITING

Fountain Valley, California, 92708, United States

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89bio Clinical Study Site
RECRUITING

Fresno, California, 93720, United States

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89bio Clinical Study Site
WITHDRAWN

Huntington Park, California, 90255, United States
89bio Clinical Study Site
RECRUITING

La Jolla, California, 92037-0887, United States

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RECRUITING

Los Angeles, California, 90033, United States

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89bio Clinical Study Site
RECRUITING

Los Angeles, California, 90048, United States

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89bio Clinical Study Site
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Pasadena, California, 91105, United States

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Poway, California, 92064, United States

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89bio Clinical Study Site
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Redwood City, California, 94063, United States

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Rialto, California, 92377, United States

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Sacramento, California, 95817, United States

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89bio Clinical Study Site
WITHDRAWN

Santa Ana, California, 92704, United States
89bio Clinical Study Site
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Littleton, Colorado, 80120, United States

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89bio Clinical Study Site
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Clermont, Florida, 34711, United States

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89bio Clinical Study Site
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Fort Myers, Florida, 33912, United States

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89bio Clinical Study Site
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Gainesville, Florida, 32610, United States

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89bio Clinical Study Site
RECRUITING

Hialeah Gardens, Florida, 33016, United States

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89bio Clinical Study Site
RECRUITING

Homestead, Florida, 33030, United States

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89bio Clinical Study Site
RECRUITING

Jacksonville, Florida, 32224, United States

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89bio Clinical Study Site
RECRUITING

Jacksonville, Florida, 32256, United States

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89bio Clinical Study Site
WITHDRAWN

Lady Lake, Florida, 32159, United States
89bio Clinical Study Site
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Lakewood Rch, Florida, 34211, United States

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89bio Clinical Study Site
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Lehigh Acres, Florida, 33936, United States

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89bio Clinical Study Site
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Maitland, Florida, 32751, United States

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89bio Clinical Study Site
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Miami, Florida, 33144, United States

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89bio Clinical Study Site
RECRUITING

Miami, Florida, 33176-1530, United States

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RECRUITING

Miami, Florida, 33176-7947, United States

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89bio Clinical Study Site
RECRUITING

New Port Richey, Florida, 34653, United States

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Ocala, Florida, 34471, United States

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RECRUITING

Ocoee, Florida, 34761, United States

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89bio Clinical Study Site
WITHDRAWN

Orlando, Florida, 32825, United States
89bio Clinical Study Site
RECRUITING

University Park, Florida, 34201, United States

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RECRUITING

Viera, Florida, 32940, United States

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89bio Clinical Study Site
RECRUITING

Winter Park, Florida, 32789, United States

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89bio Clinical Study Site
RECRUITING

Athens, Georgia, 30607, United States

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89bio Clinical Study Site
RECRUITING

Atlanta, Georgia, 30309, United States

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89bio Clinical Study Site
RECRUITING

Chicago, Illinois, 60611, United States

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89bio Clinical Study Site
RECRUITING

Hammond, Indiana, 46324, United States

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89bio Clinical Study Site
RECRUITING

New Albany, Indiana, 47150, United States

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89bio Clinical Study Site
RECRUITING

South Bend, Indiana, 46635, United States

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89bio Clinical Study Site
RECRUITING

Iowa City, Iowa, 52242, United States

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89bio Clinical Study Site
RECRUITING

Kansas City, Kansas, 66160, United States

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89bio Clinical Study Site
RECRUITING

Topeka, Kansas, 66606, United States

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89bio Clinical Study Site
RECRUITING

Lafayette, Louisiana, 70503, United States

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89bio Clinical Study Site
RECRUITING

West Monroe, Louisiana, 71291, United States

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89bio Clinical Study Site
RECRUITING

Baltimore, Maryland, 21202, United States

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RECRUITING

Glen Burnie, Maryland, 21061, United States

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RECRUITING

Greenbelt, Maryland, 20770, United States

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RECRUITING

Burlington, Massachusetts, 01805, United States

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89bio Clinical Study Site
RECRUITING

Ann Arbor, Michigan, 48109, United States

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RECRUITING

Clinton Township, Michigan, 48038, United States

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89bio Clinical Study Site
RECRUITING

Detroit, Michigan, 48202, United States

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89bio Clinical Study Site
RECRUITING

Wyoming, Michigan, 49519, United States

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89bio Clinical Study Site
RECRUITING

Ypsilanti, Michigan, 48197, United States

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89bio Clinical Study Site
RECRUITING

Minneapolis, Minnesota, 55413, United States

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RECRUITING

Rochester, Minnesota, 55905, United States

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89bio Clinical Study Site
RECRUITING

Flowood, Mississippi, 39232, United States

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89bio Clinical Study Site
WITHDRAWN

Tupelo, Mississippi, 38801, United States
89bio Clinical Study Site
RECRUITING

St Louis, Missouri, 63110, United States

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89bio Clinical Study Site
RECRUITING

Las Vegas, Nevada, 89106, United States

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89bio Clinical Study Site
WITHDRAWN

Florham Park, New Jersey, 07932, United States
89bio Clinical Study Site
RECRUITING

Somers Point, New Jersey, 08244, United States

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89bio Clinical Study Site
RECRUITING

Albuquerque, New Mexico, 87109, United States

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New York, New York, 10016, United States

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RECRUITING

New York, New York, 10021, United States

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89bio Clinical Study Site
WITHDRAWN

New York, New York, 10033, United States
89bio Clinical Study Site
RECRUITING

Asheville, North Carolina, 28801, United States

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Charlotte, North Carolina, 28207, United States

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89bio Clinical Study Site
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Durham, North Carolina, 27710, United States

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89bio Clinical Study Site
RECRUITING

Fayetteville, North Carolina, 28304, United States

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89bio Clinical Study Site
RECRUITING

Greenville, North Carolina, 27834, United States

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89bio Clinical Study Site
RECRUITING

Winston-Salem, North Carolina, 27103, United States

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RECRUITING

Akron, Ohio, 44320, United States

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RECRUITING

Cincinnati, Ohio, 45267, United States

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89bio Clinical Study Site
RECRUITING

Cleveland, Ohio, 44106, United States

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89bio Clinical Study Site
RECRUITING

Columbus, Ohio, 43210, United States

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89bio Clinical Study Site
RECRUITING

Dayton, Ohio, 45414, United States

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89bio Clinical Study Site
RECRUITING

Liberty Township, Ohio, 45044, United States

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89bio Clinical Study Site
RECRUITING

Westlake, Ohio, 44145, United States

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89bio Clinical Study Site
RECRUITING

Philadelphia, Pennsylvania, 19148, United States

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89bio Clinical Study Site
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

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89bio Clinical Study Site
RECRUITING

East Greenwich, Rhode Island, 02818, United States

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89bio Clinical Study Site
RECRUITING

Charleston, South Carolina, 29425, United States

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89bio Clinical Study Site
RECRUITING

Columbia, South Carolina, 29204, United States

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89bio Clinical Study Site
RECRUITING

Rapid City, South Dakota, 57701, United States

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89bio Clinical Study Site
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Cordova, Tennessee, 38018, United States

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89bio Clinical Study Site
RECRUITING

Hermitage, Tennessee, 37076, United States

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89bio Clinical Study Site
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Nashville, Tennessee, 37211, United States

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89bio Clinical Study Site
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Amarillo, Texas, 79106, United States

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89bio Clinical Study Site
RECRUITING

Austin, Texas, 78745, United States

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89bio Clinical Study Site
RECRUITING

Austin, Texas, 78757-8059, United States

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89bio Clinical Study Site
RECRUITING

Austin, Texas, 78757-8066, United States

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89bio Clinical Study Site
RECRUITING

Brownsville, Texas, 78520, United States

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89bio Clinical Study Site
RECRUITING

DeSoto, Texas, 75115, United States

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89bio Clinical Study Site
WITHDRAWN

Edinburg, Texas, 78539, United States
89bio Clinical Study Site
RECRUITING

Farmers Branch, Texas, 75234, United States

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89bio Clinical Study Site
RECRUITING

Fort Worth, Texas, 76104, United States

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89bio Clinical Study Site
RECRUITING

Harlingen, Texas, 78550, United States

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89bio Clinical Study Site
RECRUITING

Houston, Texas, 77030, United States

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89bio Clinical Study Site
RECRUITING

Houston, Texas, 77074, United States

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89bio Clinical Study Site
RECRUITING

Houston, Texas, 77099, United States

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89bio Clinical Study Site
RECRUITING

Lubbock, Texas, 79410, United States

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89bio Clinical Study Site
RECRUITING

Pearland, Texas, 77584, United States

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89bio Clinical Study Site
RECRUITING

San Antonio, Texas, 78209, United States

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89bio Clinical Study Site
RECRUITING

San Antonio, Texas, 78229-4801, United States

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89bio Clinical Study Site
RECRUITING

San Antonio, Texas, 78229-5069, United States

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89bio Clinical Study Site
RECRUITING

San Marcos, Texas, 78666, United States

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89bio Clinical Study Site
RECRUITING

Waco, Texas, 76710, United States

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89bio Clinical Study Site
RECRUITING

Waco, Texas, 76712, United States

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89bio Clinical Study Site
RECRUITING

Sandy City, Utah, 84092, United States

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89bio Clinical Study Site
RECRUITING

West Jordan, Utah, 84088, United States

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89bio Clinical Study Site
RECRUITING

Richmond, Virginia, 23226, United States

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89bio Clinical Study Site
WITHDRAWN

Richmond, Virginia, 23229, United States
89bio Clinical Study Site
RECRUITING

Richmond, Virginia, 23236, United States

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89bio Clinical Study Site
RECRUITING

Richmond, Virginia, 23298, United States

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89bio Clinical Study Site
RECRUITING

Seattle, Washington, 98101, United States

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89bio Clinical Study Site
RECRUITING

Seattle, Washington, 98105, United States

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89bio Clinical Study Site
RECRUITING

Buenos Aires, C1012AAR, Argentina

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89bio Clinical Study Site
RECRUITING

Buenos Aires, C1125ABE, Argentina

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89bio Clinical Study Site
RECRUITING

Buenos Aires, C1199ABB, Argentina

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89bio Clinical Study Site
RECRUITING

Buenos Aires, C1425BGH, Argentina

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89bio Clinical Study Site
RECRUITING

Buenos Aires, CP 1061, Argentina

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89bio Clinical Study Site
RECRUITING

CABA, C1430CKE, Argentina

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89bio Clinical Study Site
RECRUITING

Capital Federal, C1280AEB, Argentina

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89bio Clinical Study Site
RECRUITING

Pilar, B1629AHJ, Argentina

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89bio Clinical Study Site
RECRUITING

Adelaide, SA 5000, Australia

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89bio Clinical Study Site
RECRUITING

Fitzroy, 03065, Australia

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89bio Clinical Study Site
RECRUITING

Greenslopes, 04120, Australia

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89bio Clinical Study Site
RECRUITING

Heidelberg, 3084, Australia

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89bio Clinical Study Site
RECRUITING

Herston, Qld 4029, Australia

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89bio Clinical Study Site
RECRUITING

Murdoch, 06150, Australia

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89bio Clinical Study Site
RECRUITING

Perth, 06000, Australia

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89bio Clinical Study Site
RECRUITING

South Brisbane, 04101, Australia

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89bio Clinical Study Site
RECRUITING

Brussels, 01070, Belgium

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89bio Clinical Study Site
RECRUITING

Brussels, 01090, Belgium

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89bio Clinical Study Site
RECRUITING

Brussels, 1200, Belgium

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89bio Clinical Study Site
RECRUITING

Edegem, 02650, Belgium

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89bio Clinical Study Site
RECRUITING

Genk, 03600, Belgium

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89bio Clinical Study Site
RECRUITING

Ghent, 09000, Belgium

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89bio Clinical Study Site
RECRUITING

Roeselare, 08800, Belgium

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89bio Clinical Study Site
RECRUITING

Barretos, 14784-400, Brazil

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89bio Clinical Study Site
RECRUITING

Belo Horizonte, 30220-140, Brazil

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89bio Clinical Study Site
RECRUITING

Botucatu, 18618-687, Brazil

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89bio Clinical Study Site
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Goiânia, 74605-050, Brazil

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89bio Clinical Study Site
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Porto Alegre, 90035-903, Brazil

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89bio Clinical Study Site
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Salvador, 41820-460, Brazil

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89bio Clinical Study Site
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São José do Rio Preto, 15090-000, Brazil

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89bio Clinical Study Site
RECRUITING

Gorna Oryahovitsa, 05100, Bulgaria

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89bio Clinical Study Site
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Sofia, 01202, Bulgaria

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89bio Clinical Study Site
RECRUITING

Sofia, 01407, Bulgaria

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89bio Clinical Study Site
RECRUITING

Stara Zagora, 06003, Bulgaria

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89bio Clinical Study Site
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Calgary, Alberta, T2N 4Z6, Canada

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89bio Clinical Study Site
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Vancouver, British Columbia, V5Z 1M9, Canada

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Vancouver, British Columbia, V6Z2K5, Canada

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89bio Clinical Study Site
RECRUITING

Winnipeg, Manitoba, R3E 3P4, Canada

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89bio Clinical Study Site
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London, Ontario, N6A5A5, Canada

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89bio Clinical Study Site
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Ottawa, Ontario, K1H 8L6, Canada

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89bio Clinical Study Site
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Toronto, Ontario, M6H3M1, Canada

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89bio Clinical Study Site
RECRUITING

Vaughan, L4L 4Y7, Canada

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89bio Clinical Study Site
RECRUITING

Amiens, 80054, France

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89bio Clinical Study Site
RECRUITING

Dijon, 21000, France

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89bio Clinical Study Site
RECRUITING

Limoges, 87000, France

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89bio Clinical Study Site
RECRUITING

Lyon, 69004, France

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89bio Clinical Study Site
RECRUITING

Montpellier, 34295, France

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89bio Clinical Study Site
RECRUITING

Nice, 06202, France

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89bio Clinical Study Site
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Paris, 75012, France

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89bio Clinical Study Site
RECRUITING

Paris, 75013, France

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89bio Clinical Study Site
RECRUITING

Paris, 75014, France

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89bio Clinical Study Site
RECRUITING

Pessac, 33604, France

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89bio Clinical Study Site
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Strasbourg, 67091, France

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89bio Clinical Study Site
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Toulouse, 31400, France

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89bio Clinical Study Site
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Vandœuvre-lès-Nancy, 54500, France

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89bio Clinical Study Site
RECRUITING

Vénissieux, 69694, France

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89bio Clinical Study Site
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Villejuif, 94800, France

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89bio Clinical Study Site
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Chemnitz, 9116, Germany

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89bio Clinical Study Site
RECRUITING

Frankfurt, 60590, Germany

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89bio Clinical Study Site
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Freiburg im Breisgau, 79110, Germany

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89bio Clinical Study Site
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Hanover, 30625, Germany

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89bio Clinical Study Site
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Homburg, 66421, Germany

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89bio Clinical Study Site
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Münster, 48149, Germany

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89bio Clinical Study Site
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Hong Kong, Hong Kong

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89bio Clinical Study Site
RECRUITING

Shatin, Hong Kong

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89bio Clinical Study Site
RECRUITING

Budapest, 01027, Hungary

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89bio Clinical Study Site
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Budapest, 01088, Hungary

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89bio Clinical Study Site
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Budapest, H-1097, Hungary

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89bio Clinical Study Site
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Afula, 1834111, Israel

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89bio Clinical Study Site
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Beersheba, 8410101, Israel

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89bio Clinical Study Site
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Haifa, 3109601, Israel

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ENROLLING_BY_INVITATION

Haifa, 3436212, Israel
89bio Clinical Study Site
RECRUITING

Jerusalem, 9112001, Israel

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Nahariya, 2210001, Israel

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Petah Tikva, 49100, Israel

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89bio Clinical Study Site
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Tel Aviv, 69710, Israel

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Tel Litwinsky, 5265601, Israel

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89bio Clinical Study Site
RECRUITING

Bergamo, 24127, Italy

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89bio Clinical Study Site
RECRUITING

Foggia, 71121, Italy

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Milan, 20122, Italy

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Milan, 20162, Italy

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Novara, 28100, Italy

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Palermo, 90127, Italy

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Roma, 00128, Italy

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89bio Clinical Study Site
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Rome, 00168, Italy

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89bio Clinical Study Site
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Rozzano, 20089, Italy

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RECRUITING

Torino, 10124, Italy

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89bio Clinical Study Site
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Chihuahua City, 31217, Mexico

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89bio Clinical Study Site
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Cuautitlán Izcalli, CP 54769, Mexico

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89bio Clinical Study Site
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Cuernavaca, 62250, Mexico

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89bio Clinical Study Site
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Jalisco, 44130, Mexico

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89bio Clinical Study Site
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Mexico City, 03330, Mexico

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Mexico City, 06700, Mexico

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Mérida, 97070, Mexico

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89bio Clinical Study Site
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Monterrey, 64310, Mexico

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89bio Clinical Study Site
RECRUITING

Amsterdam, 1081 HV, Netherlands

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Rotterdam, 3015GD, Netherlands

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89bio Clinical Study Site
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Tilburg, 5022 GC, Netherlands

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89bio Clinical Study Site
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Utrecht, 3584 CX, Netherlands

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89bio Clinical Study Site
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Katowice, 40-752, Poland
89bio Clinical Study Site
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Krakow, 31-501, Poland

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89bio Clinical Study Site
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Lodz, 90-302, Poland

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Lodz, 91-363, Poland

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Mysłowice, 41-400, Poland

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89bio Clinical Study Site
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Warsaw, 00-215, Poland
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Warsaw, 04-501, Poland

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Wroclaw, 53-673, Poland

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89bio Clinical Study Site
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Singapore, 119074, Singapore

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Singapore, 169608, Singapore

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89bio Clinical Study Site
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Singapore, 308433, Singapore

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89bio Clinical Study Site
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Singapore, 529889, Singapore

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89bio Clinical Study Site
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Bucheon-si, 14584, South Korea

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89bio Clinical Study Site
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Busan, 49241, South Korea

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Daegu, 42415, South Korea

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Daegu, 700-712, South Korea

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89bio Clinical Study Site
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Seoul, 03080, South Korea

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Seoul, 06591, South Korea

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89bio Clinical Study Site
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Seoul, 07061, South Korea

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89bio Clinical Study Site
RECRUITING

Seoul, 07895, South Korea

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89bio Clinical Study Site
RECRUITING

Almería, 04009, Spain

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Badalona, 08916, Spain

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89bio Clinical Study Site
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Barcelona, 08003, Spain

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Barcelona, 08035, Spain

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Barcelona, 08041, Spain

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89bio Clinical Study Site
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Córdoba, 14004, Spain

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Madrid, 28007, Spain

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89bio Clinical Study Site
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Málaga, 29010, Spain
89bio Clinical Study Site
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Pontevedra, 36071, Spain

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89bio Clinical Study Site
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Santander, 39008, Spain

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Santiago de Compostela, 15706, Spain

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89bio Clinical Study Site
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Zaragoza, 50009, Spain

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89bio Clinical Study Site
RECRUITING

Chiayi City, 60002, Taiwan

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89bio Clinical Study Site
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Kaohsiung City, 80756, Taiwan

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89bio Clinical Study Site
RECRUITING

Tainan, 00704, Taiwan

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89bio Clinical Study Site
RECRUITING

Bornova, İzmir, 35040, Turkey (Türkiye)

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89bio Clinical Study Site
RECRUITING

Merkez, Rize Province, 53020, Turkey (Türkiye)

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89bio Clinical Study Site
RECRUITING

Ankara, 06100, Turkey (Türkiye)

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89bio Clinical Study Site
RECRUITING

Ankara, 6800, Turkey (Türkiye)

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RECRUITING

Istanbul, 34010, Turkey (Türkiye)

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89bio Clinical Study Site
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Istanbul, 34722, Turkey (Türkiye)

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89bio Clinical Study Site
RECRUITING

Yüreğir, 1370, Turkey (Türkiye)

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89bio Clinical Study Site
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Aberdeen, AB25 2ZN, United Kingdom

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89bio Clinical Study Site
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Bristol, BS10 5NB, United Kingdom

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89bio Clinical Study Site
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Leeds, LS9 7TF, United Kingdom

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89bio Clinical Study Site
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London, E1 1BB, United Kingdom

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89bio Clinical Study Site
RECRUITING

London, NW3 2QG, United Kingdom

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89bio Clinical Study Site
RECRUITING

London, SE5 9RS, United Kingdom

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89bio Clinical Study Site
RECRUITING

London, W2 1NY, United Kingdom

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89bio Clinical Study Site
RECRUITING

Oxford, OX3 9DU, United Kingdom

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89bio Clinical Study Site
RECRUITING

Plymouth, PL6 8DH, United Kingdom

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89bio Clinical Study Site
RECRUITING

Port Talbot, SA12 7BR, United Kingdom

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89bio Clinical Study Site
RECRUITING

Portsmouth, P06 3LY, United Kingdom

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89bio Clinical Study Site
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Southampton, SO16 6YD, United Kingdom

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Conditions

Explore the condition pages connected to this study.

METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS (MASH) / NONALCOHOLIC STEATOHEPATITIS (NASH) WITH COMPENSATED CIRRHOSIS