New pill aims to tame dangerous liver pressure

NCT ID NCT05161481

Terminated Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

Summary

This study tested if a new oral medicine called Avenciguat could safely reduce high blood pressure in the main vein leading to the liver (portal hypertension) in adults with compensated cirrhosis. About 80 participants were randomly assigned to take one of two doses of the drug or a placebo (sugar pill) twice daily for 24 weeks. Doctors measured the pressure inside a liver vein using a thin tube at the start and during the study to see if the treatment worked.

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Contacts and locations

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Locations

AKH - Medical University of Vienna

Vienna, 1090, Austria
ASST Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy
American Research Corporation at the Texas Liver Institute

San Antonio, Texas, 78215, United States
Azienda Ospedaliera Policlinico di Modena

Modena, 41124, Italy
Beijing Friendship Hospital

Beijing, 100050, China
Beijing Youan Hospital, Capital Medical University

Beijing, 100071, China
California Liver Research Institute

Pasadena, California, 91105, United States
Centre Hospitalier de l'Universite de Montreal (CHUM)

Montreal, Quebec, H2X 0A9, Canada
Edegem - UNIV UZ Antwerpen

Edegem, 2650, Belgium
Floridian Clinical Research-Miami Lakes-68368

Miami Lakes, Florida, 33016, United States
Fondazione Policlinico Universitario A. Gemelli IRCCS

Roma, 00195, Italy
HOP Rangueil

Toulouse, 31059, France
HOP d'Angers

Angers, 49933, France
Hospital Italiano de Buenos Aires

CABA, C1199ABB, Argentina
Hospital Puerta de Hierro

Majadahonda, 28222, Spain
Hospital Ramón y Cajal

Madrid, 28034, Spain
Hospital Vall d'Hebron

Barcelona, 08035, Spain
Hvidovre Hospital

Hvidovre, 2650, Denmark
Inland Empire Clinical Trials, LLC

Rialto, California, 92377, United States
Kitasato University Hospital

Kanagawa, Sagamihara, 252-0375, Japan
Leids Universitair Medisch Centrum (LUMC)

Leiden, 2333 ZA, Netherlands
Medical University of Innsbruck

Innsbruck, 6020, Austria
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
NanFang Hosptial

Guangzhou, 510515, China
National Hospital Organization Yokohama Medical Center

Kanagawa, Yokohama, 245-8575, Japan
Northwell Health Center for Liver Disease

Manhasset, New York, 11030, United States
Osaka Metropolitan University Hospital

Osaka, Osaka, 545-8586, Japan
Ospedale Regionale di Lugano

Viganello, 6962, Switzerland
Policlinico "Paolo Giaccone"

Palermo, 90127, Italy
Queen Elizabeth Hospital Birmingham

Birmingham, B15 2TH, United Kingdom
Regional Institute of Gastroenterology Hepatology "Prof. Dr. O. Fodor"

Cluj-Napoca, 400000, Romania
Shin-yurigaoka General Hospital

Kanagawa, Kawasaki, 215-0026, Japan
Singapore General Hospital

Singapore, 169608, Singapore
Soon Chun Hyang University Hospital Bucheon

Bucheon-si, Gyeonggi-do, 14584, South Korea
St Mary's Hospital

London, W2 1NY, United Kingdom
St. Josefs-Hospital, Wiesbaden

Wiesbaden, 65189, Germany
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
The Affiliated Hospital of Hangzhou Normal University

Hangzhou, 310000, China
ULS de Santa Maria, E.P.E

Lisbon, 1649-035, Portugal
University Hospital Dubrava

Zagreb, 10000, Croatia
Universitätsklinikum Münster

Münster, 48149, Germany
Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Mainz, 55131, Germany
Western Galilee Hospital

Nahariya, 2210001, Israel
Yokohama City University Hospital

Kanagawa, Yokohama, 236-0004, Japan
Yonsei University Wonju Severance Christian Hospital

Wonju-si, Gangwon State, 26426, South Korea

Conditions

Explore the condition pages connected to this study.

HYPERTENSION, PORTAL