Two-Drug immune attack tested against standard liver cancer treatments

NCT ID NCT04039607

Ongoing Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This large, late-stage trial is comparing a new two-drug immunotherapy combination (nivolumab plus ipilimumab) against the current standard drug treatments (sorafenib or lenvatinib) for people with advanced liver cancer who haven't had prior drug therapy. The main goal is to see if the immunotherapy combination helps patients live longer. The study enrolled over 730 participants to determine which approach is more effective.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Hospital de Base de Sao Jose do Rio Preto

São José do Rio Preto, São Paulo, 15090-000, Brazil
Local Institution

Ann Arbor, Michigan, 48105, United States
Local Institution

Salvador, Estado de Bahia, 41253190, Brazil
Local Institution

Brno, 60200, Czechia
Local Institution

Marseille, 13009, France
Local Institution

München, 81675, Germany
Local Institution

Craiova, 200385, Romania
Local Institution - 0001

Melbourne, Victoria, 3004, Australia
Local Institution - 0002

Westmead, New South Wales, 2145, Australia
Local Institution - 0003

Kogarah, New South Wales, 2217, Australia
Local Institution - 0004

Birtinya, Queensland, 4560, Australia
Local Institution - 0005

Frankfurt am Main, Hesse, 60590, Germany
Local Institution - 0006

Hamburg, 20246, Germany
Local Institution - 0007

Moscow, 115478, Russia
Local Institution - 0008

Federal District, 72115700, Belgium
Local Institution - 0009

Adelaide, South Australia, 5000, Australia
Local Institution - 0012

Viña del Mar, Región de Valparaíso, 2520598, Chile
Local Institution - 0013

Herston, Queensland, 4029, Australia
Local Institution - 0015

Rio de Janeiro, 22793-080, Brazil
Local Institution - 0016

Paranã, 81520-060, Brazil
Local Institution - 0017

Singapore, 258499, Singapore
Local Institution - 0018

Detroit, Michigan, 48202, United States
Local Institution - 0019

Clayton, Victoria, 3168, Australia
Local Institution - 0020

St Albans, Victoria, 3021, Australia
Local Institution - 0022

São Paulo, 01323-900, Brazil
Local Institution - 0023

São Paulo, 01246-000, Brazil
Local Institution - 0024

Santiago, Santiago Metropolitan, 7710007, Chile
Local Institution - 0025

Pessac, 33604, France
Local Institution - 0026

Fitzroy, Victoria, 3065, Australia
Local Institution - 0027

Louisville, Kentucky, 40217, United States
Local Institution - 0028

Cologne, 50937, Germany
Local Institution - 0029

Arkhangelsk, 163045, Russia
Local Institution - 0031

Mainz, 55131, Germany
Local Institution - 0032

Hong Kong, Hong Kong
Local Institution - 0033

Parma, 43126, Italy
Local Institution - 0034

Brussels, 1070, Belgium
Local Institution - 0035

San Juan, 00927-4308, Puerto Rico
Local Institution - 0036

Hong Kong, 999077, Hong Kong
Local Institution - 0037

Caba, Buenos Aires, C1090AAS, Argentina
Local Institution - 0038

Liverpool, New South Wales, 1871, Australia
Local Institution - 0039

Milan, 20122, Italy
Local Institution - 0040

Zaragoza, 50009, Spain
Local Institution - 0041

Madrid, 28007, Spain
Local Institution - 0042

Toulouse, 31059, France
Local Institution - 0043

Toledo, Ohio, 43623, United States
Local Institution - 0044

Vicenza, 36100, Italy
Local Institution - 0045

Majadahonda, 28222, Spain
Local Institution - 0046

Lubbock, Texas, 79410, United States
Local Institution - 0047

Auckland, 1023, New Zealand
Local Institution - 0048

Singapore, 168583, Singapore
Local Institution - 0049

Otwock, 05-400, Poland
Local Institution - 0050

São Paulo, 04038-034, Brazil
Local Institution - 0051

Villejuif, 94800, France
Local Institution - 0052

Essen, 45147, Germany
Local Institution - 0053

North Rhine-Westphalia, 45136, Germany
Local Institution - 0054

Jaú, São Paulo, 17210-120, Brazil
Local Institution - 0055

Barcelona, 08036, Spain
Local Institution - 0056

Mannheim, 68167, Germany
Local Institution - 0057

Wiener Neustadt, Lower Austria, 2700, Austria
Local Institution - 0058

San Miguel de Tucumán, 4000, Argentina
Local Institution - 0059

Changsha, Hunan, 410011, China
Local Institution - 0060

Pelotas, Rio Grande do Sul, 96020-360, Brazil
Local Institution - 0061

Salvador, Estado de Bahia, 41950-640, Brazil
Local Institution - 0062

Jongno-gu, Seoul, 03080, South Korea
Local Institution - 0063

Bern, 3010, Switzerland
Local Institution - 0064

Leuven, 3000, Belgium
Local Institution - 0065

Klagenfurt, 9020, Austria
Local Institution - 0066

Barnaul, 656045, Russia
Local Institution - 0067

Nice, 6202, France
Local Institution - 0068

Amiens, 80054, France
Local Institution - 0069

Clichy, 92110, France
Local Institution - 0070

Lyon, 69004, France
Local Institution - 0071

Vandœuvre-lès-Nancy, 54500, France
Local Institution - 0072

Pyatigorsk, 357502, Russia
Local Institution - 0073

Sochi, 354057, Russia
Local Institution - 0074

Chelyabinsk, 454087, Russia
Local Institution - 0075

Saint Petersburg, 197758, Russia
Local Institution - 0077

Washington D.C., District of Columbia, 20007, United States
Local Institution - 0078

Taipei, 11266, Taiwan
Local Institution - 0079

Rome, 00168, Italy
Local Institution - 0081

Grenoble, 38043, France
Local Institution - 0082

Montpellier, 34295, France
Local Institution - 0084

Candiolo, 10060, Italy
Local Institution - 0085

Pamplona, 31008, Spain
Local Institution - 0087

El Palmar, 30120, Spain
Local Institution - 0088

Santander, 39008, Spain
Local Institution - 0089

Barcelona, 08908, Spain
Local Institution - 0090

Córdoba, 14004, Spain
Local Institution - 0091

Saint Petersburg, 198255, Russia
Local Institution - 0092

Warsaw, 02-034, Poland
Local Institution - 0093

Madrid, 28028, Spain
Local Institution - 0094

La Serena, Coquimbo Region, 1720430, Chile
Local Institution - 0095

Santiago, Santiago Metropolitan, 0, Chile
Local Institution - 0096

Kaohsiung City, 83301, Taiwan
Local Institution - 0097

Gyeonggi-do, 010408, South Korea
Local Institution - 0098

Gyeongsangnam-do, 050612, South Korea
Local Institution - 0099

Haine-Saint-Paul, 7100, Belgium
Local Institution - 0100

Novara, 28100, Italy
Local Institution - 0101

Rozzano, Milano, 20089, Italy
Local Institution - 0102

Hanover, 30625, Germany
Local Institution - 0103

Craiova, Dolj, 200542, Romania
Local Institution - 0104

Liège, 4000, Belgium
Local Institution - 0105

Taichung, 40447, Taiwan
Local Institution - 0107

Hangzhou, Zhejiang, 310022, China
Local Institution - 0108

Hangzhou, Zhejiang, 310000, China
Local Institution - 0109

Changsha, Hunan, 410006, China
Local Institution - 0110

Meldola, Forli-Cesena, 47014, Italy
Local Institution - 0111

Siena, 53100, Italy
Local Institution - 0112

Roma, 00128, Italy
Local Institution - 0114

Sankt Pölten, Lower Austria, 3100, Austria
Local Institution - 0116

Caen, 14033, France
Local Institution - 0118

Leipzig, 04103, Germany
Local Institution - 0120

Hefei, Anhui, 230022, China
Local Institution - 0121

Fuzhou, Fujian, 350014, China
Local Institution - 0122

Minato-ku, Tokyo, 105-8470, Japan
Local Institution - 0123

Shenyang, Liaoning, 110004, China
Local Institution - 0124

Ghent, 9000, Belgium
Local Institution - 0125

Guangzhou, Guangdong, 510000, China
Local Institution - 0127

Sayama, Osaka, 5898511, Japan
Local Institution - 0128

Minato, Tokyo, 105-8470, Japan
Local Institution - 0129

London, SE5 9RS, United Kingdom
Local Institution - 0130

Nanjing, Jiangsu, 210002, China
Local Institution - 0131

Dalian, Liaoning, 116023, China
Local Institution - 0132

Shenyang, Liaoning, 110117, China
Local Institution - 0133

Xi'an, Shaanxi, 710038, China
Local Institution - 0134

Shanghai, Shanghai Municipality, 200032, China
Local Institution - 0135

Harbin, Heilongjiang, 150081, China
Local Institution - 0136

Buenos Aires, C1426ANZ, Argentina
Local Institution - 0137

Poitiers, 86021, France
Local Institution - 0138

Dijon, 21000, France
Local Institution - 0139

Seoul, 06351, South Korea
Local Institution - 0140

Seoul, 05505, South Korea
Local Institution - 0141

Seoul, 03722, South Korea
Local Institution - 0142

Busan, 49241, South Korea
Local Institution - 0143

Seongnam-si, Gyeonggi-do, 13496, South Korea
Local Institution - 0144

Taipei, 10002, Taiwan
Local Institution - 0145

Nanchang, Jiangxi, 330006, China
Local Institution - 0146

Hefei, Anhui, 230601, China
Local Institution - 0147

Xi'an, Shan3xi, 710061, China
Local Institution - 0148

Gdansk, 80219, Poland
Local Institution - 0149

Nanchang, Jiangxi, 330019, China
Local Institution - 0150

Guangzhou, Guangdong, 510515, China
Local Institution - 0151

Fuzhou, Fujian, 350002, China
Local Institution - 0152

Beijing, Beijing Municipality, 100142, China
Local Institution - 0153

Qingdao, Shandong, 266000, China
Local Institution - 0154

Guildford, Surrey, GU2 7XX, United Kingdom
Local Institution - 0155

Sapporo, 0600033, Japan
Local Institution - 0156

Santiago, Santiago Metropolitan, 8380456, Chile
Local Institution - 0157

Duarte, California, 91010-3012, United States
Local Institution - 0160

Edinburgh, EH4 2XU, United Kingdom
Local Institution - 0162

Changchun, Jilin, 130021, China
Local Institution - 0163

Timișoara, 300166, Romania
Local Institution - 0164

Bucharest, 022328, Romania
Local Institution - 0165

Cluj-Napoca, 400015, Romania
Local Institution - 0166

Changchun, Jilin, 130102, China
Local Institution - 0167

Guro-gu, Seoul, 8308, South Korea
Local Institution - 0168

Tainan, 704, Taiwan
Local Institution - 0171

London, Greater London, W12 OHS, United Kingdom
Local Institution - 0172

Salt Lake City, Utah, 84106, United States
Local Institution - 0173

Taoyuan District, 333, Taiwan
Local Institution - 0174

Singapore, 308442, Singapore
Local Institution - 0175

Beijing, Beijing Municipality, 100000, China
Local Institution - 0176

Kanazawa, Ishikawa-ken, 920-8641, Japan
Local Institution - 0177

Hiroshima, 7348551, Japan
Local Institution - 0178

Fukuoka, 830-0011, Japan
Local Institution - 0179

Chongqing, Sichuan, 400030, China
Local Institution - 0181

Brasília, Federal District, 70200-730, Brazil
Local Institution - 0185

Freiburg im Breisgau, 79106, Germany
Local Institution - 0186

Vienna, 1090, Austria
Local Institution - 0188

Graz, 8036, Austria
Local Institution - 0189

Kyoto, Kyoto, 602-8566, Japan
Local Institution - 0190

Baltimore, Maryland, 21287, United States
Local Institution - 0192

Edmonton, Alberta, T6G 1Z2, Canada
Local Institution - 0193

Kashiwa-shi, Chiba, 2778577, Japan
Local Institution - 0194

Pilar, Buenos Aires, B1629ODT, Argentina
Local Institution - 0199

Musashino-shi, Tokyo, 180-8610, Japan
Local Institution - 0200

Yokohama, Kanagawa, 2320024, Japan
Local Institution - 0201

Mitaka, Tokyo, 181-8611, Japan
Local Institution - 0202

Houston, Texas, 77030, United States
Local Institution - 0203

Matsuyama, Ehime, 790-0024, Japan
Local Institution - 0204

Chiba, 260-8677, Japan
Local Institution - 0216

Viña del Mar, Región de Valparaíso, 2540402, Chile
Local Institution - 0219

Padua, 35128, Italy
Local Institution - 0231

Bonn, 53127, Germany
Local Institution - 0258

Iruma-gun, Saitama, 3500495, Japan
Local Institution - 0259

Izunokuni-shi, Shizuoka, 410-2295, Japan
Local Institution - 0261

Kashihara, Nara, 634-8522, Japan
Local Institution - 0262

Yokohama, Kanagawa, 241-8515, Japan
Local Institution - 0263

Abeno-ku, Osaka, 5458586, Japan
Local Institution - 0270

Tainan, 736, Taiwan
Local Institution - 0271

Taichung, 40705, Taiwan
Local Institution - 0272

Kaohsiung City, 807, Taiwan
Local Institution - 0274

Prague, Prague, 14059, Czechia
Local Institution - 0278

Vitória, Espírito Santo, 29055-450, Brazil
Local Institution - 0279

Ijuí, Rio Grande do Sul, 98700-000, Brazil
Local Institution - 0281

Saga, Saga-ken, 8408571, Japan
Local Institution - 0282

Rosario, Santa Fe Province, 2000, Argentina
Local Institution - 0283

Santiago, RM, 7630372, Chile
Local Institution - 0284

Pittsburgh, Pennsylvania, 15212, United States
Local Institution - 0286

Christchurch, Canterbury, 8011, New Zealand
Local Institution - 0288

Coronado, California, 92118, United States
Local Institution - 0289

Rio Piedras, 00935, Puerto Rico
Local Institution - 0290

Madrid, 28035, Spain
Local Institution - 0292

Tucson, Arizona, 85719, United States
Local Institution - 0295

Newark, New Jersey, 07103, United States
Local Institution - 0296

Temuco, Región de la Araucanía, 4780000, Chile
Local Institution - 0297

Barcelona, 08035, Spain
Local Institution - 0298

Ghent, 9000, Belgium
Local Institution - 0304

Dallas, Texas, 75203, United States
Local Institution - 0307

Xi'an, Shan3xi, 710100, China

Conditions

Explore the condition pages connected to this study.

HEPATOCELLULAR CARCINOMA